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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NDFIP1

Summary for NDFIP1

Gene information	Gene symbol	NDFIP1
	Ensembl ID	ENSG00000131507
	Entrez ID	80762
	Gene name	Nedd4 family interacting protein 1
	Synonyms	MGC10924\|N4WBP5
	Gene type	protein_coding
	UniProtAcc	Q9BT67

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Dataset with differentially expressed gene: NDFIP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.423503	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.287821	3.47e-12
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	-0.304975	1.07e-02
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.48603	1.55e-38
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.338256	1.82e-20
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.283321	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.34828	6.91e-12
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.299211	4.56e-13
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.418852	1.79e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.359332	1.74e-15
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.262646	3.86e-05
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.263227	5.18e-44
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.331302	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.349605	0.00e+00

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Expression of NDFIP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NDFIP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NDFIP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NDFIP1	hsa-miR-4438	94.3418	NM_030571
NDFIP1	hsa-miR-101-3p	94.0889	NM_030571
NDFIP1	hsa-miR-153-5p	91.5958	NM_030571
NDFIP1	hsa-miR-580-5p	91.3087	NM_030571
NDFIP1	hsa-miR-338-5p	90.8578	NM_030571
NDFIP1	hsa-miR-1277-3p	90.539	NM_030571
NDFIP1	hsa-miR-2276-3p	90.4544	NM_030571
NDFIP1	hsa-miR-3665	90.2508	NM_030571
NDFIP1	hsa-miR-7110-5p	89.973	NM_030571
NDFIP1	hsa-miR-6842-5p	89.973	NM_030571
NDFIP1	hsa-miR-196a-3p	89.0237	NM_030571
NDFIP1	hsa-miR-1305	88.55	NM_030571
NDFIP1	hsa-miR-520g-3p	88.5123	NM_030571
NDFIP1	hsa-miR-520h	88.5123	NM_030571
NDFIP1	hsa-miR-200a-5p	87.9304	NM_030571
NDFIP1	hsa-miR-200b-5p	87.9304	NM_030571
NDFIP1	hsa-miR-4801	87.4514	NM_030571
NDFIP1	hsa-miR-1246	87.1358	NM_030571
NDFIP1	hsa-miR-4731-3p	87.1266	NM_030571
NDFIP1	hsa-miR-8085	86.7772	NM_030571
NDFIP1	hsa-miR-6731-5p	86.7772	NM_030571
NDFIP1	hsa-miR-548e-5p	86.1161	NM_030571
NDFIP1	hsa-miR-6894-5p	85.7122	NM_030571
NDFIP1	hsa-miR-3910	85.3896	NM_030571
NDFIP1	hsa-miR-139-5p	85.2164	NM_030571
NDFIP1	hsa-miR-3074-5p	84.6604	NM_030571
NDFIP1	hsa-miR-4777-5p	84.5035	NM_030571
NDFIP1	hsa-miR-205-3p	83.9862	NM_030571
NDFIP1	hsa-miR-6752-5p	83.909	NM_030571
NDFIP1	hsa-miR-526b-5p	83.1971	NM_030571
NDFIP1	hsa-miR-6510-3p	82.1678	NM_030571
NDFIP1	hsa-miR-582-5p	81.9126	NM_030571
NDFIP1	hsa-miR-5197-5p	81.5039	NM_030571
NDFIP1	hsa-miR-6728-3p	81.3273	NM_030571
NDFIP1	hsa-miR-4313	81.0345	NM_030571
NDFIP1	hsa-miR-499b-3p	81.0279	NM_030571
NDFIP1	hsa-miR-499a-3p	81.0279	NM_030571

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Motifs and transcription factors (TFs) regulating NDFIP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NDFIP1	cisbp__M00341	PAX6 (directAnnotation).
NDFIP1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
NDFIP1	transfac_pro__M01199	TRIM28 (directAnnotation).
NDFIP1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
NDFIP1	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
NDFIP1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
NDFIP1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
NDFIP1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
NDFIP1	cisbp__M00968	MTF2 (directAnnotation).
NDFIP1	transfac_pro__M12697	ZNF142 (directAnnotation).
NDFIP1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NDFIP1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
NDFIP1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
NDFIP1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
NDFIP1	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
NDFIP1	transfac_public__M00491	PATZ1 (directAnnotation).
NDFIP1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
NDFIP1	taipale_tf_pairs__GCM2_HES7_RTRNKGGTNNNGCACGYGNN_CAP_repr	GCM2; HES7 (directAnnotation).
NDFIP1	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
NDFIP1	taipale_tf_pairs__GCM1_FIGLA_CASSTGNNNNNNNNNNTGCGGG_CAP_repr	FIGLA; GCM1 (directAnnotation).
NDFIP1	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
NDFIP1	transfac_pro__M01298	MECP2 (directAnnotation).
NDFIP1	transfac_pro__M00492	STAT1 (directAnnotation).
NDFIP1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NDFIP1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
NDFIP1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
NDFIP1	metacluster_161.4	LHX9 (directAnnotation).
NDFIP1	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
NDFIP1	metacluster_161.3	LHX9 (directAnnotation).
NDFIP1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
NDFIP1	transfac_pro__M07310	SP5 (directAnnotation).
NDFIP1	cisbp__M07938	E2F1 (directAnnotation).
NDFIP1	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
NDFIP1	transfac_pro__M04817	ZBTB33 (directAnnotation).
NDFIP1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
NDFIP1	tfdimers__MD00483	ZBTB14 (directAnnotation).
NDFIP1	transfac_pro__M02089	E2F3 (directAnnotation).
NDFIP1	transfac_pro__M07317	CTBP1 (directAnnotation).
NDFIP1	transfac_pro__M00716	ZBTB14 (directAnnotation).
NDFIP1	transfac_pro__M03806	ZBTB7C (directAnnotation).
NDFIP1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
NDFIP1	transfac_pro__M04893	TAF1 (directAnnotation).
NDFIP1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
NDFIP1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
NDFIP1	transfac_pro__M04916	TAF1 (directAnnotation).
NDFIP1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
NDFIP1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
NDFIP1	hdpi__RARA	RARA (directAnnotation).
NDFIP1	hdpi__HIP2	UBE2K (directAnnotation).
NDFIP1	transfac_pro__M01240	GTF2IRD1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."