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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MYLIP

Summary for MYLIP

Gene information	Gene symbol	MYLIP
	Ensembl ID	ENSG00000007944
	Entrez ID	29116
	Gene name	myosin regulatory light chain interacting protein
	Synonyms	IDOL\|MIR
	Gene type	protein_coding
	UniProtAcc	Q8WY64

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Dataset with differentially expressed gene: MYLIP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.19767	2.46e-02
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.610443	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.262325	1.03e-24
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	0.256215	2.08e-33
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.311692	1.77e-10
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.300498	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.45891	2.58e-20
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.251763	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.375957	0.00e+00

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Expression of MYLIP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYLIP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MYLIP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYLIP	hsa-miR-455-5p	97.4687	NM_013262
MYLIP	hsa-miR-6505-5p	97.0899	NM_013262
MYLIP	hsa-miR-147b-5p	97.0157	NM_013262
MYLIP	hsa-miR-4261	96.6049	NM_013262
MYLIP	hsa-miR-365b-3p	94.9265	NM_013262
MYLIP	hsa-miR-365a-3p	94.9265	NM_013262
MYLIP	hsa-miR-506-3p	94.029	NM_013262
MYLIP	hsa-miR-124-3p	94.029	NM_013262
MYLIP	hsa-miR-222-3p	93.8564	NM_013262
MYLIP	hsa-miR-221-3p	93.8564	NM_013262
MYLIP	hsa-miR-3714	93.841	NM_013262
MYLIP	hsa-miR-3910	93.841	NM_013262
MYLIP	hsa-miR-548n	93.7518	NM_013262
MYLIP	hsa-miR-633	93.1283	NM_013262
MYLIP	hsa-miR-3609	91.9771	NM_013262
MYLIP	hsa-miR-548ah-5p	91.9771	NM_013262
MYLIP	hsa-miR-340-5p	91.045	NM_013262
MYLIP	hsa-miR-6882-5p	89.3425	NM_013262
MYLIP	hsa-miR-542-3p	88.6669	NM_013262
MYLIP	hsa-miR-4797-3p	88.5569	NM_013262
MYLIP	hsa-miR-6796-5p	87.988	NM_013262
MYLIP	hsa-miR-7157-3p	87.2115	NM_013262
MYLIP	hsa-miR-6737-3p	87.2115	NM_013262
MYLIP	hsa-miR-6889-3p	87.2115	NM_013262
MYLIP	hsa-miR-12136	86.875	NM_013262
MYLIP	hsa-miR-3163	86.611	NM_013262
MYLIP	hsa-miR-4791	86.536	NM_013262
MYLIP	hsa-miR-3201	86.5013	NM_013262
MYLIP	hsa-miR-20a-5p	86.3674	NM_013262
MYLIP	hsa-miR-4796-3p	86.3674	NM_013262
MYLIP	hsa-miR-106b-5p	86.3674	NM_013262
MYLIP	hsa-miR-548v	84.6375	NM_013262
MYLIP	hsa-miR-187-5p	84.6375	NM_013262
MYLIP	hsa-miR-20b-5p	84.6233	NM_013262
MYLIP	hsa-miR-519d-3p	84.6233	NM_013262
MYLIP	hsa-miR-17-5p	84.6233	NM_013262
MYLIP	hsa-miR-93-5p	84.6233	NM_013262
MYLIP	hsa-miR-106a-5p	84.6233	NM_013262
MYLIP	hsa-miR-526b-3p	84.6233	NM_013262
MYLIP	hsa-miR-622	84.1893	NM_013262
MYLIP	hsa-miR-5694	83.4553	NM_013262
MYLIP	hsa-miR-6529-3p	83.1825	NM_013262
MYLIP	hsa-miR-5008-3p	83.1825	NM_013262
MYLIP	hsa-miR-3658	82.7431	NM_013262
MYLIP	hsa-miR-875-5p	82.4183	NM_013262
MYLIP	hsa-miR-545-5p	81.9601	NM_013262
MYLIP	hsa-miR-92a-3p	81.4638	NM_013262
MYLIP	hsa-miR-92b-3p	81.4638	NM_013262
MYLIP	hsa-miR-32-5p	81.4638	NM_013262
MYLIP	hsa-miR-4698	80.8138	NM_013262

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Motifs and transcription factors (TFs) regulating MYLIP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MYLIP	transfac_pro__M01783	SP2 (directAnnotation).
MYLIP	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MYLIP	cisbp__M00341	PAX6 (directAnnotation).
MYLIP	transfac_pro__M01253	CNOT3 (directAnnotation).
MYLIP	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
MYLIP	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
MYLIP	cisbp__M00968	MTF2 (directAnnotation).
MYLIP	transfac_pro__M04817	ZBTB33 (directAnnotation).
MYLIP	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
MYLIP	jaspar__MA0748.2	YY2 (directAnnotation).
MYLIP	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
MYLIP	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
MYLIP	swissregulon__hs__HSF2	HSF2 (directAnnotation).
MYLIP	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
MYLIP	hocomoco__DPRX_HUMAN.H11MO.0.D	DPRX (directAnnotation).
MYLIP	metacluster_111.5	E4F1; E4F1 (directAnnotation).
MYLIP	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
MYLIP	taipale__NR4A2_full_AGGTCANNNNNTGACCT_repr	NR4A2 (directAnnotation).
MYLIP	transfac_pro__M05483	ZBTB1 (directAnnotation).
MYLIP	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
MYLIP	cisbp__M04023	CREB1 (directAnnotation).
MYLIP	hocomoco__HSF1_HUMAN.H11MO.1.A	HSF1 (directAnnotation).
MYLIP	metacluster_161.1	HOXA9 (directAnnotation).
MYLIP	transfac_pro__M06071	ZNF814 (directAnnotation).
MYLIP	transfac_pro__M05990	ZNF69 (directAnnotation).
MYLIP	transfac_pro__M05755	ZNF718 (directAnnotation).
MYLIP	transfac_pro__M05642	ZNF879 (directAnnotation).
MYLIP	transfac_pro__M05805	ZNF546 (directAnnotation).
MYLIP	transfac_pro__M06609	ZKSCAN4 (directAnnotation).
MYLIP	transfac_pro__M06586	ZNF479 (directAnnotation).
MYLIP	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
MYLIP	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
MYLIP	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
MYLIP	transfac_pro__M06259	ZNF91 (directAnnotation).
MYLIP	transfac_pro__M06700	ZNF71 (directAnnotation).
MYLIP	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
MYLIP	kznf__CTCF_Transfac.7_Transfac	CTCF (directAnnotation).
MYLIP	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_HT	HOXB13; ONECUT2 (directAnnotation).
MYLIP	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
MYLIP	hdpi__NRL	NRL (directAnnotation).
MYLIP	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
MYLIP	hdpi__RARA	RARA (directAnnotation).
MYLIP	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
MYLIP	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
MYLIP	hdpi__HTATIP2	HTATIP2 (directAnnotation).
MYLIP	transfac_pro__M01199	TRIM28 (directAnnotation).
MYLIP	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
MYLIP	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."