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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MYH9

Summary for MYH9

Gene information	Gene symbol	MYH9
	Ensembl ID	ENSG00000100345
	Entrez ID	4627
	Gene name	myosin heavy chain 9
	Synonyms	DFNA17\|EPSTS\|FTNS\|MHA\|NMHC-II-A\|NMMHCA
	Gene type	protein_coding
	UniProtAcc	P35579

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Dataset with differentially expressed gene: MYH9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.0566	7.46e-14
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.773082	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.359265	1.79e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.427239	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.509119	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.355236	5.61e-06
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.394212	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.354842	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.34913	4.74e-06
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.285985	3.51e-24
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.341845	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.301043	2.13e-35
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.315074	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	Mono/Macro	-0.276977	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	-0.381885	3.59e-07
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.252771	3.21e-13
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.324916	0.00e+00
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.330017	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.983404	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.466603	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.523274	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.322859	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.322099	4.20e-17
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.315829	2.26e-06
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.416511	4.71e-33
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.322947	1.67e-10
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.588641	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.783581	0.00e+00

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Expression of MYH9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYH9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MYH9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYH9	hsa-miR-6825-5p	96.0735	NM_002473
MYH9	hsa-miR-3714	95.9838	NM_002473
MYH9	hsa-miR-103a-3p	95.6017	NM_002473
MYH9	hsa-miR-107	95.6017	NM_002473
MYH9	hsa-miR-10526-3p	95.3961	NM_002473
MYH9	hsa-miR-3120-3p	95.1799	NM_002473
MYH9	hsa-miR-4753-3p	94.0628	NM_002473
MYH9	hsa-miR-492	92.9733	NM_002473
MYH9	hsa-miR-6512-5p	92.1387	NM_002473
MYH9	hsa-miR-542-3p	91.7434	NM_002473
MYH9	hsa-miR-376a-5p	91.6436	NM_002473
MYH9	hsa-miR-433-3p	91.5669	NM_002473
MYH9	hsa-miR-9-5p	90.2351	NM_002473
MYH9	hsa-miR-190a-3p	89.8666	NM_002473
MYH9	hsa-miR-124-3p	88.795	NM_002473
MYH9	hsa-miR-506-3p	88.795	NM_002473
MYH9	hsa-miR-3649	87.8085	NM_002473
MYH9	hsa-miR-597-3p	87.7524	NM_002473
MYH9	hsa-miR-5002-5p	87.5214	NM_002473
MYH9	hsa-miR-483-3p	86.6565	NM_002473
MYH9	hsa-miR-133a-3p	86.381	NM_002473
MYH9	hsa-miR-133b	86.381	NM_002473
MYH9	hsa-miR-4786-3p	85.9109	NM_002473
MYH9	hsa-miR-1249-5p	85.1196	NM_002473
MYH9	hsa-miR-9986	84.8388	NM_002473
MYH9	hsa-miR-1294	84.8388	NM_002473
MYH9	hsa-miR-4325	84.8238	NM_002473
MYH9	hsa-miR-410-3p	83.7459	NM_002473
MYH9	hsa-miR-449a	82.7798	NM_002473
MYH9	hsa-miR-34a-5p	82.7798	NM_002473
MYH9	hsa-miR-449b-5p	82.7798	NM_002473
MYH9	hsa-miR-34c-5p	82.7798	NM_002473
MYH9	hsa-miR-661	82.1793	NM_002473
MYH9	hsa-miR-367-3p	81.2265	NM_002473
MYH9	hsa-miR-92b-3p	81.2265	NM_002473
MYH9	hsa-miR-92a-3p	81.2265	NM_002473
MYH9	hsa-miR-363-3p	81.2265	NM_002473
MYH9	hsa-miR-32-5p	81.2265	NM_002473
MYH9	hsa-miR-3665	81.2219	NM_002473
MYH9	hsa-miR-6504-5p	81.2102	NM_002473
MYH9	hsa-miR-3085-3p	81.2102	NM_002473
MYH9	hsa-miR-3064-5p	81.2102	NM_002473
MYH9	hsa-miR-1258	80.3088	NM_002473
MYH9	hsa-miR-4281	80.2266	NM_002473

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Motifs and transcription factors (TFs) regulating MYH9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MYH9	metacluster_32.24	ZNF287 (directAnnotation).
MYH9	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
MYH9	transfac_pro__M04916	TAF1 (directAnnotation).
MYH9	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MYH9	cisbp__M00968	MTF2 (directAnnotation).
MYH9	cisbp__M00341	PAX6 (directAnnotation).
MYH9	metacluster_198.3	ZFP64 (directAnnotation).
MYH9	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MYH9	hdpi__ZNF304	ZNF304 (directAnnotation).
MYH9	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
MYH9	transfac_pro__M01199	TRIM28 (directAnnotation).
MYH9	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MYH9	transfac_pro__M03806	ZBTB7C (directAnnotation).
MYH9	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MYH9	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MYH9	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MYH9	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
MYH9	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
MYH9	transfac_pro__M07458	HOXC13 (directAnnotation).
MYH9	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
MYH9	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
MYH9	tfdimers__MD00183	CRX; YY1 (directAnnotation).
MYH9	tfdimers__MD00225	NKX6-2; POU5F1 (directAnnotation).
MYH9	metacluster_161.13	ISX (directAnnotation).
MYH9	kznf__ZNF33B_Imbeault2017_RP_RCADE	ZNF33B (directAnnotation).
MYH9	metacluster_150.2	POU3F1 (directAnnotation).
MYH9	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
MYH9	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
MYH9	transfac_pro__M01253	CNOT3 (directAnnotation).
MYH9	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
MYH9	metacluster_3.10	KLF2; KLF4 (directAnnotation).
MYH9	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
MYH9	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
MYH9	transfac_pro__M12697	ZNF142 (directAnnotation).
MYH9	transfac_pro__M01303	SP1 (directAnnotation).
MYH9	metacluster_3.14	WT1; WT1 (directAnnotation).
MYH9	transfac_pro__M07397	ZNF148 (directAnnotation).
MYH9	metacluster_187.7	FEZF1; FEZF1; ZNF384; ZNF384; ZNF384 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
MYH9	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
MYH9	metacluster_22.17	NFE2 (directAnnotation).
MYH9	transfac_pro__M05770	ZNF77 (directAnnotation).
MYH9	transfac_pro__M06602	ZNF669 (directAnnotation).
MYH9	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
MYH9	transfac_pro__M05791	ZNF517 (directAnnotation).
MYH9	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
MYH9	metacluster_153.4	SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).
MYH9	transfac_pro__M04817	ZBTB33 (directAnnotation).
MYH9	cisbp__M07938	E2F1 (directAnnotation).
MYH9	transfac_pro__M06313	ZNF678 (directAnnotation).
MYH9	transfac_pro__M07431	SOX11 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MYH9	"Artenimol"	DB11638	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."