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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MKRN1

Summary for MKRN1

Gene information	Gene symbol	MKRN1
	Ensembl ID	ENSG00000133606
	Entrez ID	23608
	Gene name	makorin ring finger protein 1
	Synonyms	RNF61
	Gene type	protein_coding
	UniProtAcc	Q9UHC7

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Dataset with differentially expressed gene: MKRN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.284634	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	NK cells	-0.275181	1.35e-24
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.297929	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.270473	2.21e-34
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.769812	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.492537	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.27626	2.53e-22
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.266214	0.00e+00

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Expression of MKRN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MKRN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MKRN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MKRN1	hsa-miR-106b-5p	98.4299	NM_013446
MKRN1	hsa-miR-20a-5p	98.4299	NM_013446
MKRN1	hsa-miR-93-5p	98.0259	NM_013446
MKRN1	hsa-miR-106a-5p	98.0259	NM_013446
MKRN1	hsa-miR-20b-5p	98.0259	NM_013446
MKRN1	hsa-miR-519d-3p	98.0259	NM_013446
MKRN1	hsa-miR-17-5p	98.0259	NM_013446
MKRN1	hsa-miR-526b-3p	97.5143	NM_013446
MKRN1	hsa-miR-6765-3p	94.2838	NM_013446
MKRN1	hsa-miR-497-3p	94.2189	NM_013446
MKRN1	hsa-miR-3671	92.687	NM_001145125
MKRN1	hsa-miR-3130-5p	92.5376	NM_013446
MKRN1	hsa-miR-548ah-5p	92.2894	NM_013446
MKRN1	hsa-miR-3609	92.2894	NM_013446
MKRN1	hsa-miR-5004-5p	91.9686	NM_013446
MKRN1	hsa-miR-1468-3p	91.1041	NM_013446
MKRN1	hsa-miR-6124	90.9363	NM_013446
MKRN1	hsa-miR-3135a	90.8381	NM_013446
MKRN1	hsa-miR-4772-3p	90.8056	NM_013446
MKRN1	hsa-miR-4482-5p	90.2125	NM_013446
MKRN1	hsa-miR-3120-5p	88.5957	NM_013446
MKRN1	hsa-miR-6791-5p	88.2118	NM_013446
MKRN1	hsa-miR-4292	88.2118	NM_013446
MKRN1	hsa-miR-6805-3p	88.0696	NM_001145125
MKRN1	hsa-miR-5691	88.0696	NM_001145125
MKRN1	hsa-miR-4763-5p	88.0384	NM_013446
MKRN1	hsa-miR-607	87.9533	NM_001145125
MKRN1	hsa-miR-520e-5p	86.9135	NM_001145125
MKRN1	hsa-miR-12117	86.4774	NM_001145125
MKRN1	hsa-miR-4713-3p	86.4137	NM_013446
MKRN1	hsa-miR-6738-5p	86.2331	NM_013446
MKRN1	hsa-miR-6750-5p	85.9008	NM_013446
MKRN1	hsa-miR-6822-5p	85.9008	NM_013446
MKRN1	hsa-miR-6804-3p	84.8928	NM_013446
MKRN1	hsa-miR-574-5p	84.1088	NM_013446
MKRN1	hsa-miR-19b-3p	83.8885	NM_013446
MKRN1	hsa-miR-19a-3p	83.8885	NM_013446
MKRN1	hsa-miR-4526	83.4577	NM_013446
MKRN1	hsa-miR-3660	83.4577	NM_013446
MKRN1	hsa-miR-5194	83.1589	NM_013446
MKRN1	hsa-miR-4279	82.7688	NM_001145125
MKRN1	hsa-miR-103a-1-5p	82.3923	NM_013446
MKRN1	hsa-miR-103a-2-5p	82.3923	NM_013446
MKRN1	hsa-miR-4760-5p	82.0835	NM_001145125
MKRN1	hsa-miR-450a-1-3p	81.9797	NM_013446
MKRN1	hsa-miR-1305	81.7652	NM_013446
MKRN1	hsa-miR-1266-5p	81.6176	NM_013446
MKRN1	hsa-miR-4435	81.1732	NM_013446
MKRN1	hsa-miR-4518	80.7847	NM_013446
MKRN1	hsa-miR-409-5p	80.5605	NM_013446

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Motifs and transcription factors (TFs) regulating MKRN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MKRN1	metacluster_62.3	HSF5 (directAnnotation).
MKRN1	transfac_pro__M04921	HNF4G (directAnnotation).
MKRN1	transfac_pro__M06434	ZNF787 (inferredBy_Orthology).
MKRN1	jaspar__MA0033.2	FOXL1 (directAnnotation).
MKRN1	metacluster_108.1	ZNF101; ZNF697 (directAnnotation).
MKRN1	transfac_pro__M01968	FOXO1 (directAnnotation).
MKRN1	taipale_tf_pairs__GCM1_ELK3_ACCCGCANCCGGAAGN_CAP_repr	ELK3; GCM1 (directAnnotation).
MKRN1	jaspar__MA0031.1	FOXD1 (directAnnotation).
MKRN1	metacluster_78.19	PAX7 (directAnnotation).
MKRN1	metacluster_134.4	AHDC1; ARID5B; FOXA1; FOXA1; FOXA2; FOXA2; FOXA3; FOXA3; FOXJ3; FOXO3; FOXP1; FOXP4 (directAnnotation).
MKRN1	metacluster_160.3	ZFP14; ZNF419 (directAnnotation).
MKRN1	taipale__FOXD3_DBD_RTAAAYA	FOXD3 (directAnnotation).
MKRN1	taipale_tf_pairs__E2F3_DRGX_SGCGCTAATTKN_CAP_repr	DRGX; E2F3 (directAnnotation).
MKRN1	taipale__NR4A2_full_AGGTCANNNNNTGACCT_repr	NR4A2 (directAnnotation).
MKRN1	swissregulon__hs__FOXO3	FOXO3 (directAnnotation).
MKRN1	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
MKRN1	transfac_pro__M05845	ZSCAN29 (directAnnotation).
MKRN1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MKRN1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
MKRN1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
MKRN1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
MKRN1	jaspar__MA1721.1	ZNF93 (directAnnotation).
MKRN1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
MKRN1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
MKRN1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
MKRN1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
MKRN1	transfac_pro__M01253	CNOT3 (directAnnotation).
MKRN1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
MKRN1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
MKRN1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
MKRN1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
MKRN1	jaspar__MA0748.2	YY2 (directAnnotation).
MKRN1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MKRN1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
MKRN1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
MKRN1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
MKRN1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
MKRN1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
MKRN1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
MKRN1	transfac_pro__M07310	SP5 (directAnnotation).
MKRN1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MKRN1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
MKRN1	transfac_pro__M00938	E2F1 (directAnnotation).
MKRN1	transfac_pro__M04893	TAF1 (directAnnotation).
MKRN1	transfac_pro__M04817	ZBTB33 (directAnnotation).
MKRN1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
MKRN1	transfac_pro__M12697	ZNF142 (directAnnotation).
MKRN1	tfdimers__MD00364	WT1 (directAnnotation).
MKRN1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
MKRN1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."