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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MKLN1

Summary for MKLN1

Gene information	Gene symbol	MKLN1
	Ensembl ID	ENSG00000128585
	Entrez ID	4289
	Gene name	muskelin 1
	Synonyms	TWA2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MKLN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.255331	3.31e-17

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Expression of MKLN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MKLN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MKLN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MKLN1	hsa-miR-5011-5p	99.8682	NM_001145354
MKLN1	hsa-miR-190a-3p	98.4612	NM_013255
MKLN1	hsa-miR-3658	96.877	NM_001145354
MKLN1	hsa-miR-548c-3p	96.2436	NM_013255
MKLN1	hsa-miR-4477a	95.314	NM_001145354
MKLN1	hsa-miR-7856-5p	95.2588	NM_001145354
MKLN1	hsa-miR-513b-5p	94.3845	NM_001145354
MKLN1	hsa-miR-323a-3p	93.8051	NM_001145354
MKLN1	hsa-miR-302f	93.5884	NM_001145354
MKLN1	hsa-miR-4477b	92.4138	NM_001145354
MKLN1	hsa-miR-125b-2-3p	92.3792	NM_001145354
MKLN1	hsa-miR-3143	91.0939	NM_013255
MKLN1	hsa-miR-9985	90.9941	NM_013255
MKLN1	hsa-miR-4666a-3p	90.8096	NM_013255
MKLN1	hsa-miR-5193	90.4132	NM_013255
MKLN1	hsa-miR-4668-3p	90.0302	NM_013255
MKLN1	hsa-miR-340-5p	89.8923	NM_013255
MKLN1	hsa-miR-27a-3p	89.8091	NM_013255
MKLN1	hsa-miR-27b-3p	89.8091	NM_013255
MKLN1	hsa-miR-32-3p	88.7354	NM_001145354
MKLN1	hsa-miR-4775	88.7199	NM_001145354
MKLN1	hsa-miR-410-3p	88.2448	NM_013255
MKLN1	hsa-miR-651-3p	88.2022	NM_013255
MKLN1	hsa-miR-12125	88.0857	NM_013255
MKLN1	hsa-miR-297	87.7045	NM_013255
MKLN1	hsa-miR-10527-5p	87.5493	NM_013255
MKLN1	hsa-miR-1252-5p	86.4322	NM_013255
MKLN1	hsa-miR-513a-5p	86.4069	NM_013255
MKLN1	hsa-miR-3148	86.254	NM_013255
MKLN1	hsa-miR-4659a-3p	86.1456	NM_001145354
MKLN1	hsa-miR-4659b-3p	86.1456	NM_001145354
MKLN1	hsa-miR-3163	86.0265	NM_013255
MKLN1	hsa-miR-4738-3p	85.931	NM_013255
MKLN1	hsa-miR-892c-3p	85.6678	NM_013255
MKLN1	hsa-miR-4676-3p	85.6678	NM_013255
MKLN1	hsa-miR-452-5p	85.5318	NM_013255
MKLN1	hsa-miR-4719	85.1369	NM_001145354
MKLN1	hsa-miR-205-3p	85.1203	NM_013255
MKLN1	hsa-miR-6787-3p	83.048	NM_013255
MKLN1	hsa-miR-142-5p	82.8443	NM_013255
MKLN1	hsa-miR-5582-3p	82.4076	NM_013255
MKLN1	hsa-miR-548ax	82.3941	NM_013255
MKLN1	hsa-miR-548ao-5p	82.3941	NM_013255
MKLN1	hsa-miR-6507-5p	82.0025	NM_013255
MKLN1	hsa-miR-5590-3p	81.934	NM_013255
MKLN1	hsa-miR-371a-5p	81.8364	NM_001145354
MKLN1	hsa-miR-3646	81.6395	NM_013255
MKLN1	hsa-miR-6780b-5p	81.592	NM_013255
MKLN1	hsa-miR-4725-3p	81.592	NM_013255
MKLN1	hsa-miR-10522-5p	81.4838	NM_013255

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Motifs and transcription factors (TFs) regulating MKLN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MKLN1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
MKLN1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
MKLN1	kznf__EGR2_Barrera2016.3_PBM	EGR2 (directAnnotation).
MKLN1	metacluster_23.8	GLIS1; GLIS1; GLIS1; GLIS2; GLIS2; GLIS2; GLIS2 (directAnnotation). GLIS2; GLIS3; ZXDA; ZXDB; ZXDC (inferredBy_Orthology).
MKLN1	transfac_pro__M00986	CHURC1 (directAnnotation).
MKLN1	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
MKLN1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MKLN1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
MKLN1	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSNNNNCRMN_CAP	E2F3; TBX21 (directAnnotation).
MKLN1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
MKLN1	cisbp__M00249	WT1 (directAnnotation).
MKLN1	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
MKLN1	tfdimers__MD00343	HIC1; TP53 (directAnnotation).
MKLN1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
MKLN1	transfac_public__M00373	PAX4 (directAnnotation).
MKLN1	transfac_pro__M01714	KLF15 (directAnnotation).
MKLN1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
MKLN1	cisbp__M00135	ZBTB7B (inferredBy_Orthology).
MKLN1	tfdimers__MD00366	MTF1; OVOL2 (directAnnotation).
MKLN1	transfac_pro__M00938	E2F1 (directAnnotation).
MKLN1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MKLN1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
MKLN1	transfac_pro__M07310	SP5 (directAnnotation).
MKLN1	cisbp__M00341	PAX6 (directAnnotation).
MKLN1	swissregulon__hs__PATZ1	PATZ1 (directAnnotation).
MKLN1	metacluster_159.3	ARID3A; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; HMGXB4; KLF16; MBD1; RAD21; RAD21; RAD21; RXRA; SMC3; SMC3; ZNF576; ZNF654; ZNF764 (directAnnotation). CTCF; CTCF; CTCF; CTCF; CTCFL (inferredBy_Orthology).
MKLN1	transfac_pro__M08818	KLF8 (directAnnotation).
MKLN1	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."