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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MID1IP1

Summary for MID1IP1

Gene information	Gene symbol	MID1IP1
	Ensembl ID	ENSG00000165175
	Entrez ID	58526
	Gene name	MID1 interacting protein 1
	Synonyms	FLJ10386\|G12-like\|MIG12\|STRAIT11499\|THRSPL
	Gene type	protein_coding
	UniProtAcc	Q9NPA3

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Dataset with differentially expressed gene: MID1IP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.40393	1.63e-18
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.317495	8.08e-23
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.441448	2.90e-23
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.340082	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.303337	6.11e-43
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.260436	1.55e-23
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.33274	0.00e+00

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Expression of MID1IP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MID1IP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MID1IP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MID1IP1	hsa-miR-6839-5p	96.4682	NM_001098790
MID1IP1	hsa-miR-378j	95.932	NM_001098790
MID1IP1	hsa-miR-454-3p	92.4245	NM_001098790
MID1IP1	hsa-miR-4295	91.0236	NM_001098790
MID1IP1	hsa-miR-301a-3p	91.0236	NM_001098790
MID1IP1	hsa-miR-301b-3p	91.0236	NM_001098790
MID1IP1	hsa-miR-130b-3p	91.0236	NM_001098790
MID1IP1	hsa-miR-3666	91.0236	NM_001098790
MID1IP1	hsa-miR-130a-3p	91.0236	NM_001098790
MID1IP1	hsa-miR-194-5p	90.3466	NM_001098790
MID1IP1	hsa-miR-218-1-3p	88.6008	NM_001098790
MID1IP1	hsa-miR-4782-5p	88.4063	NM_001098790
MID1IP1	hsa-miR-5706	88.4063	NM_001098790
MID1IP1	hsa-miR-3148	87.0353	NM_001098790
MID1IP1	hsa-miR-382-3p	86.706	NM_001098790
MID1IP1	hsa-miR-4795-3p	85.6555	NM_001098790
MID1IP1	hsa-miR-210-3p	84.99	NM_001098790
MID1IP1	hsa-miR-147b-3p	84.99	NM_001098790
MID1IP1	hsa-miR-561-3p	83.4413	NM_001098790
MID1IP1	hsa-miR-6501-3p	82.3921	NM_001098790

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Motifs and transcription factors (TFs) regulating MID1IP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MID1IP1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
MID1IP1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
MID1IP1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
MID1IP1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
MID1IP1	transfac_pro__M02089	E2F3 (directAnnotation).
MID1IP1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
MID1IP1	transfac_pro__M04817	ZBTB33 (directAnnotation).
MID1IP1	tfdimers__MD00483	ZBTB14 (directAnnotation).
MID1IP1	cisbp__M07938	E2F1 (directAnnotation).
MID1IP1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
MID1IP1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
MID1IP1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
MID1IP1	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
MID1IP1	jaspar__MA1122.1	TFDP1 (directAnnotation).
MID1IP1	tfdimers__MD00221	FOXG1; FOXO1; GABPA (directAnnotation).
MID1IP1	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNTTRCGYAAN_CAP	CEBPB; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."