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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: METTL9

Summary for METTL9

Gene information	Gene symbol	METTL9
	Ensembl ID	ENSG00000284548
	Entrez ID	51108
	Gene name	methyltransferase like 9
	Synonyms	DREV1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: METTL9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.511096	4.02e-02
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.307748	1.37e-11
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.519528	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.259068	1.01e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.254373	1.45e-03
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.28449	3.60e-37
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.598896	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.770719	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.366476	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.280676	4.90e-10
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.577152	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.296495	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.274662	0.00e+00

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Expression of METTL9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to METTL9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating METTL9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
METTL9	hsa-miR-3685	95.1651	NM_001077180
METTL9	hsa-miR-6839-3p	93.9844	NM_001077180
METTL9	hsa-miR-155-3p	93.6986	NM_001077180
METTL9	hsa-miR-3661	93.3436	NM_001077180
METTL9	hsa-miR-6765-3p	92.9428	NM_001077180
METTL9	hsa-miR-515-5p	92.919	NM_001077180
METTL9	hsa-miR-519e-5p	92.919	NM_001077180
METTL9	hsa-miR-631	92.7712	NM_001077180
METTL9	hsa-miR-519d-5p	92.5727	NM_001077180
METTL9	hsa-miR-603	91.483	NM_001077180
METTL9	hsa-miR-4723-5p	91.2627	NM_001077180
METTL9	hsa-miR-1283	91.0185	NM_001077180
METTL9	hsa-miR-329-3p	90.2128	NM_001077180
METTL9	hsa-miR-362-3p	90.2128	NM_001077180
METTL9	hsa-miR-137-3p	89.9793	NM_001077180
METTL9	hsa-miR-3680-3p	89.9267	NM_001077180
METTL9	hsa-miR-3119	88.8066	NM_001077180
METTL9	hsa-miR-520d-5p	87.2355	NM_001077180
METTL9	hsa-miR-524-5p	87.2355	NM_001077180
METTL9	hsa-miR-6716-5p	86.9418	NM_001077180
METTL9	hsa-miR-5698	86.8939	NM_001077180
METTL9	hsa-miR-6870-5p	86.8939	NM_001077180
METTL9	hsa-miR-7111-5p	86.8939	NM_001077180
METTL9	hsa-miR-3941	86.657	NM_001077180
METTL9	hsa-miR-576-5p	86.6412	NM_001077180
METTL9	hsa-miR-4263	86.6412	NM_001077180
METTL9	hsa-miR-7109-5p	85.9631	NM_001077180
METTL9	hsa-miR-218-1-3p	82.87	NM_001077180
METTL9	hsa-miR-511-5p	82.8413	NM_001077180
METTL9	hsa-miR-6080	82.3752	NM_001077180
METTL9	hsa-miR-4799-5p	81.6373	NM_001077180
METTL9	hsa-miR-141-5p	81.2054	NM_001077180
METTL9	hsa-miR-4652-3p	80.7658	NM_001077180
METTL9	hsa-miR-877-3p	80.6946	NM_001077180

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Motifs and transcription factors (TFs) regulating METTL9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
METTL9	metacluster_198.3	ZFP64 (directAnnotation).
METTL9	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
METTL9	hdpi__NRL	NRL (directAnnotation).
METTL9	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
METTL9	tfdimers__MD00483	ZBTB14 (directAnnotation).
METTL9	metacluster_7.13	ZFX (directAnnotation).
METTL9	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
METTL9	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
METTL9	transfac_pro__M02089	E2F3 (directAnnotation).
METTL9	transfac_pro__M02898	SMAD3 (directAnnotation).
METTL9	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
METTL9	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
METTL9	transfac_pro__M00430	E2F1 (directAnnotation).
METTL9	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
METTL9	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
METTL9	transfac_pro__M07329	SP7 (directAnnotation).
METTL9	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
METTL9	cisbp__M07938	E2F1 (directAnnotation).
METTL9	metacluster_3.14	WT1; WT1 (directAnnotation).
METTL9	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
METTL9	transfac_pro__M01837	KLF11 (directAnnotation).
METTL9	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
METTL9	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
METTL9	transfac_pro__M07310	SP5 (directAnnotation).
METTL9	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
METTL9	transfac_pro__M04817	ZBTB33 (directAnnotation).
METTL9	swissregulon__hs__KLF6	KLF6 (directAnnotation).
METTL9	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
METTL9	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
METTL9	cisbp__M00968	MTF2 (directAnnotation).
METTL9	metacluster_163.2	ZNF682 (directAnnotation).
METTL9	transfac_pro__M04916	TAF1 (directAnnotation).
METTL9	transfac_pro__M00938	E2F1 (directAnnotation).
METTL9	transfac_pro__M02090	E2F4 (directAnnotation).
METTL9	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
METTL9	transfac_pro__M01303	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."