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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: MECP2

Summary for MECP2

Gene information	Gene symbol	MECP2
	Ensembl ID	ENSG00000169057
	Entrez ID	4204
	Gene name	methyl-CpG binding protein 2
	Synonyms	MRX16\|MRX79\|RTT
	Gene type	protein_coding
	UniProtAcc	P51608

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Dataset with differentially expressed gene: MECP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.591836	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.276574	9.86e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.333016	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.28504	2.15e-22
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.302988	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.656126	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.270721	0.00e+00

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Expression of MECP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MECP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MECP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MECP2	hsa-miR-6870-5p	99.9862	NM_004992
MECP2	hsa-miR-7111-5p	99.9749	NM_004992
MECP2	hsa-miR-4723-5p	99.9749	NM_004992
MECP2	hsa-miR-5698	99.9749	NM_004992
MECP2	hsa-miR-10527-5p	99.7318	NM_004992
MECP2	hsa-miR-1275	99.4691	NM_004992
MECP2	hsa-miR-548e-5p	99.298	NM_004992
MECP2	hsa-miR-4428	99.2108	NM_004992
MECP2	hsa-miR-5196-5p	98.7995	NM_004992
MECP2	hsa-miR-1324	98.7773	NM_004992
MECP2	hsa-miR-4747-5p	98.617	NM_004992
MECP2	hsa-miR-5011-5p	98.3823	NM_004992
MECP2	hsa-miR-3202	98.2185	NM_004992
MECP2	hsa-miR-4665-5p	97.9136	NM_004992
MECP2	hsa-miR-454-3p	97.8931	NM_004992
MECP2	hsa-miR-301b-3p	97.6196	NM_004992
MECP2	hsa-miR-130a-3p	97.6196	NM_004992
MECP2	hsa-miR-301a-3p	97.6196	NM_004992
MECP2	hsa-miR-4295	97.6196	NM_004992
MECP2	hsa-miR-3666	97.6196	NM_004992
MECP2	hsa-miR-130b-3p	97.6196	NM_004992
MECP2	hsa-miR-1972	97.5141	NM_004992
MECP2	hsa-miR-6721-5p	97.5033	NM_004992
MECP2	hsa-miR-4267	97.4469	NM_004992
MECP2	hsa-miR-6766-5p	96.6411	NM_004992
MECP2	hsa-miR-6756-5p	96.5021	NM_004992
MECP2	hsa-miR-6077	96.4956	NM_004992
MECP2	hsa-miR-19a-3p	96.4156	NM_004992
MECP2	hsa-miR-19b-3p	96.4156	NM_004992
MECP2	hsa-miR-548p	96.0217	NM_004992
MECP2	hsa-miR-6882-3p	95.9114	NM_004992
MECP2	hsa-miR-625-5p	95.8709	NM_004992
MECP2	hsa-miR-1291	95.7953	NM_004992
MECP2	hsa-miR-4660	95.6093	NM_004992
MECP2	hsa-miR-4766-5p	95.5117	NM_001316337
MECP2	hsa-miR-518c-5p	95.4231	NM_004992
MECP2	hsa-miR-185-3p	95.1222	NM_004992
MECP2	hsa-miR-4306	95.0536	NM_004992
MECP2	hsa-miR-4744	95.0191	NM_004992
MECP2	hsa-miR-4447	94.833	NM_004992
MECP2	hsa-miR-6775-3p	94.7413	NM_004992
MECP2	hsa-miR-4725-3p	94.6538	NM_004992
MECP2	hsa-miR-6780b-5p	94.6538	NM_004992
MECP2	hsa-miR-505-5p	94.5303	NM_004992
MECP2	hsa-miR-1272	94.2009	NM_004992
MECP2	hsa-miR-4799-5p	93.2771	NM_004992
MECP2	hsa-miR-4516	93.2189	NM_004992
MECP2	hsa-miR-4525	93.1916	NM_004992
MECP2	hsa-miR-5010-5p	93.1916	NM_004992
MECP2	hsa-miR-4271	93.1616	NM_004992

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Motifs and transcription factors (TFs) regulating MECP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MECP2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
MECP2	transfac_pro__M07329	SP7 (directAnnotation).
MECP2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
MECP2	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
MECP2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
MECP2	transfac_pro__M02089	E2F3 (directAnnotation).
MECP2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
MECP2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MECP2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
MECP2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
MECP2	transfac_pro__M07397	ZNF148 (directAnnotation).
MECP2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
MECP2	cisbp__M07938	E2F1 (directAnnotation).
MECP2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
MECP2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
MECP2	transfac_pro__M07436	WT1 (directAnnotation).
MECP2	metacluster_3.14	WT1; WT1 (directAnnotation).
MECP2	transfac_pro__M01837	KLF11 (directAnnotation).
MECP2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
MECP2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
MECP2	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
MECP2	transfac_pro__M00716	ZBTB14 (directAnnotation).
MECP2	transfac_pro__M02090	E2F4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
MECP2	metacluster_135.10	up	CD8+ T cells	GSE164551	NA
MECP2	transfac_pro__M01298	down	Malignant cells	GSE186960	NA
MECP2	metacluster_135.10	down	Malignant cells	GSE199333	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."