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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MCM4

Summary for MCM4

Gene information	Gene symbol	MCM4
	Ensembl ID	ENSG00000104738
	Entrez ID	4173
	Gene name	minichromosome maintenance complex component 4
	Synonyms	CDC21\|CDC54\|hCdc21\|MGC33310\|P1-Cdc21
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MCM4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.486165	3.73e-30
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.44076	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.269467	4.53e-13
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.01818	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.468767	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Progenitors	-0.470327	4.61e-02

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Expression of MCM4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MCM4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MCM4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MCM4	hsa-miR-371b-5p	96.5511	NM_182746
MCM4	hsa-miR-616-5p	96.5511	NM_182746
MCM4	hsa-miR-373-5p	96.5511	NM_182746
MCM4	hsa-miR-4729	95.3188	NM_005914
MCM4	hsa-miR-216b-5p	89.8258	NM_182746
MCM4	hsa-miR-3613-3p	89.1357	NM_182746
MCM4	hsa-miR-6800-3p	87.3065	NM_182746
MCM4	hsa-miR-587	82.7907	NM_182746
MCM4	hsa-miR-23b-3p	82.7727	NM_182746
MCM4	hsa-miR-23a-3p	82.7727	NM_182746
MCM4	hsa-miR-23c	82.7727	NM_182746
MCM4	hsa-miR-6796-3p	80.3646	NM_182746

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Motifs and transcription factors (TFs) regulating MCM4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MCM4	metacluster_47.6	FOXH1 (directAnnotation).
MCM4	metacluster_184.45	ALX1 (inferredBy_Orthology).
MCM4	metacluster_161.15	NKX3-1 (directAnnotation).
MCM4	dbtfbs__mm_TBP_CH12.LX_ENCSR000ERP_merged_N1	TBP (inferredBy_Orthology).
MCM4	taipale_tf_pairs__MEIS1_DRGX_TGTCAATTA_CAP_repr	DRGX; MEIS1 (directAnnotation).
MCM4	tfdimers__MD00580	CRX; HOXA10 (directAnnotation).
MCM4	metacluster_165.2	FOXH1 (directAnnotation).
MCM4	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
MCM4	transfac_pro__M06130	ZNF254 (directAnnotation).
MCM4	metacluster_161.16	NKX3-2 (directAnnotation).
MCM4	metacluster_184.43	ALX3 (inferredBy_Orthology).
MCM4	transfac_pro__M06953	VAX1 (inferredBy_Orthology).
MCM4	transfac_pro__M06452	ZNF567 (directAnnotation).
MCM4	tfdimers__MD00055	KLF4; ZNF333 (directAnnotation).
MCM4	kznf__ZNF418_Imbeault2017_RP_ChIP-seq	ZNF418 (directAnnotation).
MCM4	tfdimers__MD00207	HOXA13; PDX1 (directAnnotation).
MCM4	metacluster_22.13	MAFK (inferredBy_Orthology).
MCM4	metacluster_161.14	ISX (directAnnotation).
MCM4	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
MCM4	metacluster_141.2	E2F2; E2F3 (directAnnotation).
MCM4	transfac_pro__M04844	MAX (directAnnotation).
MCM4	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
MCM4	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."