Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MBOAT2

Summary for MBOAT2

Gene information	Gene symbol	MBOAT2
	Ensembl ID	ENSG00000143797
	Entrez ID	129642
	Gene name	membrane bound O-acyltransferase domain containing 2
	Synonyms	FLJ14415\|FLJ90298\|LPLAT13\|OACT2
	Gene type	protein_coding
	UniProtAcc	Q6ZWT7

Top

Dataset with differentially expressed gene: MBOAT2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.392467	8.49e-15
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.469609	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.692189	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.523775	1.27e-27
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.293242	5.04e-14

Top

Expression of MBOAT2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MBOAT2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating MBOAT2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MBOAT2	hsa-miR-8485	99.21	NM_001321265
MBOAT2	hsa-miR-3658	98.9976	NM_001321265
MBOAT2	hsa-miR-664b-3p	98.6121	NM_001321265
MBOAT2	hsa-miR-579-3p	98.6121	NM_001321265
MBOAT2	hsa-miR-3714	96.3684	NM_001321265
MBOAT2	hsa-miR-4477b	96.2777	NM_001321265
MBOAT2	hsa-miR-7856-5p	95.8638	NM_001321265
MBOAT2	hsa-miR-548n	94.7259	NM_001321265
MBOAT2	hsa-miR-200c-3p	94.2665	NM_001321265
MBOAT2	hsa-miR-429	94.2665	NM_001321265
MBOAT2	hsa-miR-200b-3p	94.2665	NM_001321265
MBOAT2	hsa-miR-4262	93.911	NM_001321265
MBOAT2	hsa-miR-3910	93.8725	NM_001321265
MBOAT2	hsa-miR-124-3p	93.349	NM_001321265
MBOAT2	hsa-miR-506-3p	93.349	NM_001321265
MBOAT2	hsa-miR-3184-3p	93.2436	NM_001321265
MBOAT2	hsa-miR-942-3p	92.8979	NM_001321265
MBOAT2	hsa-miR-6124	92.781	NM_001321265
MBOAT2	hsa-miR-181b-5p	91.2773	NM_001321265
MBOAT2	hsa-miR-181d-5p	91.2773	NM_001321265
MBOAT2	hsa-miR-181c-5p	91.2773	NM_001321265
MBOAT2	hsa-miR-181a-5p	91.2773	NM_001321265
MBOAT2	hsa-miR-548ac	91.2638	NM_001321265
MBOAT2	hsa-miR-548bb-3p	91.2638	NM_001321265
MBOAT2	hsa-miR-548z	91.2638	NM_001321265
MBOAT2	hsa-miR-548h-3p	91.2638	NM_001321265
MBOAT2	hsa-miR-548d-3p	91.2638	NM_001321265
MBOAT2	hsa-miR-6505-5p	91.0665	NM_001321265
MBOAT2	hsa-miR-6833-3p	90.9677	NM_001321265
MBOAT2	hsa-miR-605-3p	90.9626	NM_001321265
MBOAT2	hsa-miR-4328	90.4877	NM_001321265
MBOAT2	hsa-miR-548t-5p	90.2995	NM_001321265
MBOAT2	hsa-miR-548az-5p	90.2995	NM_001321265
MBOAT2	hsa-miR-4747-5p	89.7804	NM_001321265
MBOAT2	hsa-miR-5196-5p	89.7804	NM_001321265
MBOAT2	hsa-miR-33b-5p	89.6617	NM_001321265
MBOAT2	hsa-miR-33a-5p	89.6617	NM_001321265
MBOAT2	hsa-miR-4676-3p	88.962	NM_001321265
MBOAT2	hsa-miR-452-5p	88.962	NM_001321265
MBOAT2	hsa-miR-892c-3p	88.962	NM_001321265
MBOAT2	hsa-miR-18b-5p	88.9154	NM_001321265
MBOAT2	hsa-miR-18a-5p	88.9154	NM_001321265
MBOAT2	hsa-miR-4735-3p	88.8731	NM_001321265
MBOAT2	hsa-miR-4446-5p	88.7194	NM_001321265
MBOAT2	hsa-miR-6893-5p	88.2234	NM_001321265
MBOAT2	hsa-miR-940	88.2234	NM_001321265
MBOAT2	hsa-miR-6808-5p	88.2234	NM_001321265
MBOAT2	hsa-miR-4768-5p	88.0609	NM_001321265
MBOAT2	hsa-miR-137-3p	88.0057	NM_001321265
MBOAT2	hsa-miR-3163	87.4458	NM_001321265

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating MBOAT2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MBOAT2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."