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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAPK1IP1L

Summary for MAPK1IP1L

Gene information	Gene symbol	MAPK1IP1L
	Ensembl ID	ENSG00000168175
	Entrez ID	93487
	Gene name	mitogen-activated protein kinase 1 interacting protein 1 like
	Synonyms	C14orf32
	Gene type	protein_coding
	UniProtAcc	Q8NDC0

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Dataset with differentially expressed gene: MAPK1IP1L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.29837	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.436549	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.27569	4.18e-28
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.457522	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.430074	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.302227	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.487956	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.623169	0.00e+00

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Expression of MAPK1IP1L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAPK1IP1L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAPK1IP1L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAPK1IP1L	hsa-miR-3613-3p	99.0052	NM_144578
MAPK1IP1L	hsa-miR-548e-5p	98.057	NM_144578
MAPK1IP1L	hsa-miR-3682-5p	96.6965	NM_144578
MAPK1IP1L	hsa-miR-7-1-3p	96.5582	NM_144578
MAPK1IP1L	hsa-miR-7-2-3p	95.8738	NM_144578
MAPK1IP1L	hsa-miR-548c-3p	95.5811	NM_144578
MAPK1IP1L	hsa-miR-4290	94.9047	NM_144578
MAPK1IP1L	hsa-miR-524-5p	94.6205	NM_144578
MAPK1IP1L	hsa-miR-520d-5p	94.6205	NM_144578
MAPK1IP1L	hsa-miR-587	94.1305	NM_144578
MAPK1IP1L	hsa-miR-4698	92.8698	NM_144578
MAPK1IP1L	hsa-miR-10527-5p	92.6534	NM_144578
MAPK1IP1L	hsa-miR-511-5p	92.4548	NM_144578
MAPK1IP1L	hsa-miR-570-3p	89.97	NM_144578
MAPK1IP1L	hsa-miR-373-5p	89.3049	NM_144578
MAPK1IP1L	hsa-miR-616-5p	89.3049	NM_144578
MAPK1IP1L	hsa-miR-371b-5p	89.3049	NM_144578
MAPK1IP1L	hsa-miR-12136	88.8685	NM_144578
MAPK1IP1L	hsa-miR-888-3p	88.7543	NM_144578
MAPK1IP1L	hsa-miR-634	87.9142	NM_144578
MAPK1IP1L	hsa-miR-4262	87.4788	NM_144578
MAPK1IP1L	hsa-miR-3133	87.4466	NM_144578
MAPK1IP1L	hsa-miR-2278	86.8739	NM_144578
MAPK1IP1L	hsa-miR-3665	86.8217	NM_144578
MAPK1IP1L	hsa-miR-5580-3p	86.6546	NM_144578
MAPK1IP1L	hsa-miR-4653-5p	86.5418	NM_144578
MAPK1IP1L	hsa-miR-3921	86.5418	NM_144578
MAPK1IP1L	hsa-miR-8062	86.4426	NM_144578
MAPK1IP1L	hsa-miR-6832-3p	86.1119	NM_144578
MAPK1IP1L	hsa-miR-449c-5p	85.7267	NM_144578
MAPK1IP1L	hsa-miR-34b-5p	85.7267	NM_144578
MAPK1IP1L	hsa-miR-2682-5p	85.5044	NM_144578
MAPK1IP1L	hsa-miR-181c-5p	85.0281	NM_144578
MAPK1IP1L	hsa-miR-181a-5p	85.0281	NM_144578
MAPK1IP1L	hsa-miR-181d-5p	85.0281	NM_144578
MAPK1IP1L	hsa-miR-181b-5p	85.0281	NM_144578
MAPK1IP1L	hsa-miR-4766-5p	83.2921	NM_144578
MAPK1IP1L	hsa-miR-1827	82.9777	NM_144578
MAPK1IP1L	hsa-miR-629-3p	82.7516	NM_144578
MAPK1IP1L	hsa-miR-6761-5p	82.5896	NM_144578
MAPK1IP1L	hsa-miR-7111-3p	82.5277	NM_144578
MAPK1IP1L	hsa-miR-409-5p	82.1927	NM_144578
MAPK1IP1L	hsa-miR-186-5p	82.0059	NM_144578

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Motifs and transcription factors (TFs) regulating MAPK1IP1L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAPK1IP1L	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
MAPK1IP1L	transfac_pro__M04893	TAF1 (directAnnotation).
MAPK1IP1L	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
MAPK1IP1L	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
MAPK1IP1L	hdpi__HIP2	UBE2K (directAnnotation).
MAPK1IP1L	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
MAPK1IP1L	hdpi__TIMELESS	TIMELESS (directAnnotation).
MAPK1IP1L	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
MAPK1IP1L	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
MAPK1IP1L	metacluster_191.5	SPDEF (inferredBy_Orthology).
MAPK1IP1L	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MAPK1IP1L	transfac_pro__M00938	E2F1 (directAnnotation).
MAPK1IP1L	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
MAPK1IP1L	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
MAPK1IP1L	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
MAPK1IP1L	hdpi__RARA	RARA (directAnnotation).
MAPK1IP1L	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MAPK1IP1L	hdpi__ELF2	ELF2 (directAnnotation).
MAPK1IP1L	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
MAPK1IP1L	jaspar__MA1583.1	ZFP57 (directAnnotation).
MAPK1IP1L	transfac_pro__M02898	SMAD3 (directAnnotation).
MAPK1IP1L	hdpi__HTATIP2	HTATIP2 (directAnnotation).
MAPK1IP1L	jaspar__MA1721.1	ZNF93 (directAnnotation).
MAPK1IP1L	transfac_pro__M04916	TAF1 (directAnnotation).
MAPK1IP1L	jaspar__MA1122.1	TFDP1 (directAnnotation).
MAPK1IP1L	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
MAPK1IP1L	transfac_pro__M07310	SP5 (directAnnotation).
MAPK1IP1L	cisbp__M01863	ZNF711 (inferredBy_Orthology).
MAPK1IP1L	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MAPK1IP1L	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
MAPK1IP1L	cisbp__M00249	WT1 (directAnnotation).
MAPK1IP1L	metacluster_182.10	ZFX (directAnnotation).
MAPK1IP1L	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
MAPK1IP1L	hdpi__TP73	TP73 (directAnnotation).
MAPK1IP1L	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
MAPK1IP1L	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
MAPK1IP1L	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
MAPK1IP1L	transfac_pro__M07483	CXXC1 (directAnnotation).
MAPK1IP1L	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MAPK1IP1L	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
MAPK1IP1L	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
MAPK1IP1L	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
MAPK1IP1L	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
MAPK1IP1L	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
MAPK1IP1L	transfac_pro__M01253	CNOT3 (directAnnotation).
MAPK1IP1L	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
MAPK1IP1L	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
MAPK1IP1L	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MAPK1IP1L	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
MAPK1IP1L	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."