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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LUC7L2

Summary for LUC7L2

Gene information	Gene symbol	LUC7L2
	Ensembl ID	ENSG00000146963
	Entrez ID	51631
	Gene name	LUC7 like 2, pre-mRNA splicing factor
	Synonyms	CGI-59\|CGI-74\|FLJ10657\|hLuc7B2\|H_NH0792N18.3\|LUC7B2
	Gene type	protein_coding
	UniProtAcc	Q9Y383

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Dataset with differentially expressed gene: LUC7L2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.250704	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.280411	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.39583	5.34e-15

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Expression of LUC7L2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LUC7L2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LUC7L2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LUC7L2	hsa-miR-4795-3p	99.3534	NM_016019
LUC7L2	hsa-miR-1288-5p	93.375	NM_016019
LUC7L2	hsa-miR-5100	93.1079	NM_016019
LUC7L2	hsa-miR-520f-3p	91.5588	NM_001244585
LUC7L2	hsa-miR-548e-5p	89.7737	NM_016019
LUC7L2	hsa-miR-126-5p	89.2742	NM_016019
LUC7L2	hsa-miR-548ar-3p	88.8002	NM_001244585
LUC7L2	hsa-miR-6128	88.6605	NM_016019
LUC7L2	hsa-miR-766-3p	88.5498	NM_001244585
LUC7L2	hsa-miR-513a-3p	87.9986	NM_016019
LUC7L2	hsa-miR-513c-3p	87.9986	NM_016019
LUC7L2	hsa-miR-4430	87.3376	NM_016019
LUC7L2	hsa-miR-3652	87.3376	NM_016019
LUC7L2	hsa-miR-548az-3p	86.8142	NM_001244585
LUC7L2	hsa-miR-548bc	86.8142	NM_001244585
LUC7L2	hsa-miR-548f-3p	86.8142	NM_001244585
LUC7L2	hsa-miR-548e-3p	86.8142	NM_001244585
LUC7L2	hsa-miR-548a-3p	86.8142	NM_001244585
LUC7L2	hsa-miR-4678	86.2626	NM_016019
LUC7L2	hsa-miR-3606-3p	85.2998	NM_016019
LUC7L2	hsa-miR-506-3p	84.7126	NM_001244585
LUC7L2	hsa-miR-124-3p	84.7126	NM_001244585
LUC7L2	hsa-miR-10522-5p	84.4248	NM_001244585
LUC7L2	hsa-miR-5582-5p	83.9769	NM_001244585
LUC7L2	hsa-miR-593-5p	83.7657	NM_001244585
LUC7L2	hsa-miR-9851-3p	83.7657	NM_001244585
LUC7L2	hsa-miR-2681-5p	83.4701	NM_001244585
LUC7L2	hsa-miR-6507-5p	83.3867	NM_001244585
LUC7L2	hsa-miR-653-5p	82.3415	NM_016019
LUC7L2	hsa-miR-524-5p	81.4476	NM_001244585
LUC7L2	hsa-miR-520d-5p	81.4476	NM_001244585
LUC7L2	hsa-miR-6876-5p	81.265	NM_001244585
LUC7L2	hsa-miR-4476	81.265	NM_001244585
LUC7L2	hsa-miR-10527-5p	80.9844	NM_016019
LUC7L2	hsa-miR-6839-3p	80.8534	NM_016019
LUC7L2	hsa-miR-3622a-5p	80.6968	NM_001244585
LUC7L2	hsa-miR-582-5p	80.4215	NM_016019

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Motifs and transcription factors (TFs) regulating LUC7L2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LUC7L2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
LUC7L2	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
LUC7L2	hdpi__FEZF2	FEZF2 (directAnnotation).
LUC7L2	cisbp__M00343	PAX6 (directAnnotation).
LUC7L2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LUC7L2	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
LUC7L2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
LUC7L2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
LUC7L2	transfac_pro__M01199	TRIM28 (directAnnotation).
LUC7L2	transfac_pro__M12694	ZFP14 (directAnnotation).
LUC7L2	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
LUC7L2	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
LUC7L2	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
LUC7L2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
LUC7L2	swissregulon__hs__KLF6	KLF6 (directAnnotation).
LUC7L2	transfac_pro__M02898	SMAD3 (directAnnotation).
LUC7L2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
LUC7L2	transfac_pro__M07387	ZBTB7A (directAnnotation).
LUC7L2	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
LUC7L2	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
LUC7L2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
LUC7L2	transfac_pro__M09837	ZNF449 (directAnnotation).
LUC7L2	transfac_pro__M00430	E2F1 (directAnnotation).
LUC7L2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
LUC7L2	jaspar__MA1122.1	TFDP1 (directAnnotation).
LUC7L2	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
LUC7L2	tfdimers__MD00364	WT1 (directAnnotation).
LUC7L2	hdpi__GTF3C2	GTF3C2 (directAnnotation).
LUC7L2	transfac_pro__M08005	TCFL5 (inferredBy_Orthology).
LUC7L2	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
LUC7L2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
LUC7L2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
LUC7L2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
LUC7L2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
LUC7L2	transfac_pro__M03876	ZBTB33 (directAnnotation).
LUC7L2	transfac_pro__M04646	FOXN4 (directAnnotation).
LUC7L2	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
LUC7L2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
LUC7L2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
LUC7L2	transfac_pro__M07329	SP7 (directAnnotation).
LUC7L2	transfac_pro__M04617	ZBTB7A (directAnnotation).
LUC7L2	transfac_pro__M07436	WT1 (directAnnotation).
LUC7L2	transfac_pro__M01858	TFAP2B (directAnnotation).
LUC7L2	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
LUC7L2	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
LUC7L2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
LUC7L2	metacluster_135.11	NR2C2 (directAnnotation).
LUC7L2	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
LUC7L2	transfac_pro__M07437	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."