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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LSM14A

Summary for LSM14A

Gene information	Gene symbol	LSM14A
	Ensembl ID	ENSG00000262860
	Entrez ID	26065
	Gene name	LSM14A mRNA processing body assembly factor
	Synonyms	C19orf13\|DKFZP434D1335\|FAM61A\|RAP55\|RAP55A
	Gene type	protein_coding
	UniProtAcc	Q8ND56

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Dataset with differentially expressed gene: LSM14A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.26713	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.454278	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.28152	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.269869	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.319178	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.422547	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.32636	2.15e-41
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.567123	3.72e-03
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.342015	0.00e+00

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Expression of LSM14A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LSM14A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LSM14A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LSM14A	hsa-miR-8485	99.997	NM_015578
LSM14A	hsa-miR-1284	99.0268	NM_001114093
LSM14A	hsa-miR-4666a-3p	98.6785	NM_001114093
LSM14A	hsa-miR-6844	98.5001	NM_001114093
LSM14A	hsa-miR-33a-3p	98.3133	NM_015578
LSM14A	hsa-miR-4699-3p	96.0912	NM_001114093
LSM14A	hsa-miR-4276	94.8697	NM_015578
LSM14A	hsa-miR-5584-3p	94.2263	NM_001114093
LSM14A	hsa-miR-155-5p	94.0859	NM_001114093
LSM14A	hsa-miR-9-5p	92.8021	NM_001114093
LSM14A	hsa-miR-6830-3p	91.7067	NM_001114093
LSM14A	hsa-miR-4652-3p	91.4416	NM_001114093
LSM14A	hsa-miR-138-5p	91.2495	NM_001114093
LSM14A	hsa-miR-6504-3p	91.1047	NM_015578
LSM14A	hsa-miR-10399-5p	91.1047	NM_015578
LSM14A	hsa-miR-9718	91.0921	NM_015578
LSM14A	hsa-miR-628-5p	90.1398	NM_015578
LSM14A	hsa-miR-577	89.8348	NM_015578
LSM14A	hsa-miR-4645-5p	89.1269	NM_001114093
LSM14A	hsa-miR-4673	88.6793	NM_001114093
LSM14A	hsa-miR-2116-5p	88.6495	NM_001114093
LSM14A	hsa-miR-148a-5p	88.3741	NM_001114093
LSM14A	hsa-miR-501-5p	88.1078	NM_001114093
LSM14A	hsa-miR-144-3p	87.9738	NM_001114093
LSM14A	hsa-miR-155-3p	87.0638	NM_001114093
LSM14A	hsa-miR-582-5p	86.5262	NM_001114093
LSM14A	hsa-miR-548ac	86.0831	NM_015578
LSM14A	hsa-miR-548d-3p	86.0831	NM_015578
LSM14A	hsa-miR-548z	86.0831	NM_015578
LSM14A	hsa-miR-548bb-3p	86.0831	NM_015578
LSM14A	hsa-miR-548h-3p	86.0831	NM_015578
LSM14A	hsa-miR-4513	86.0266	NM_015578
LSM14A	hsa-miR-6855-3p	86.0266	NM_015578
LSM14A	hsa-miR-4299	85.7855	NM_001114093
LSM14A	hsa-miR-511-5p	85.6678	NM_001114093
LSM14A	hsa-miR-3662	85.2061	NM_015578
LSM14A	hsa-miR-4778-5p	85.1704	NM_001114093
LSM14A	hsa-miR-1185-1-3p	84.8016	NM_015578
LSM14A	hsa-let-7f-2-3p	84.8016	NM_015578
LSM14A	hsa-miR-1185-2-3p	84.8016	NM_015578
LSM14A	hsa-miR-10394-5p	84.7208	NM_015578
LSM14A	hsa-miR-1205	84.7208	NM_015578
LSM14A	hsa-miR-7151-3p	84.6036	NM_015578
LSM14A	hsa-miR-500a-5p	84.507	NM_001114093
LSM14A	hsa-miR-29a-5p	84.0341	NM_015578
LSM14A	hsa-let-7a-3p	83.8163	NM_015578
LSM14A	hsa-let-7b-3p	83.8163	NM_015578
LSM14A	hsa-miR-98-3p	83.8163	NM_015578
LSM14A	hsa-let-7f-1-3p	83.8163	NM_015578
LSM14A	hsa-miR-892a	83.4853	NM_001114093

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Motifs and transcription factors (TFs) regulating LSM14A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LSM14A	metacluster_141.2	E2F2; E2F3 (directAnnotation).
LSM14A	metacluster_172.6	CHD2; E2F1 (directAnnotation).
LSM14A	metacluster_183.3	EHF; ELF3; FLI1; SPIB (directAnnotation). EHF; EHF; ELF2; ELF3; ELF4; ELF5; ERG; ERG; ETV3; ETV6; FLI1; SPI1; SPI1 (inferredBy_Orthology).
LSM14A	metacluster_183.4	ETS1 (inferredBy_Orthology).
LSM14A	transfac_pro__M06173	ZNF85 (directAnnotation).
LSM14A	hdpi__NRL	NRL (directAnnotation).
LSM14A	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
LSM14A	cisbp__M00341	PAX6 (directAnnotation).
LSM14A	cisbp__M00968	MTF2 (directAnnotation).
LSM14A	hdpi__FEZF2	FEZF2 (directAnnotation).
LSM14A	transfac_pro__M07310	SP5 (directAnnotation).
LSM14A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
LSM14A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
LSM14A	metacluster_155.11	SPZ1 (directAnnotation).
LSM14A	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
LSM14A	hdpi__HTATIP2	HTATIP2 (directAnnotation).
LSM14A	hdpi__HIP2	UBE2K (directAnnotation).
LSM14A	hdpi__ZNF304	ZNF304 (directAnnotation).
LSM14A	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
LSM14A	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
LSM14A	transfac_pro__M02089	E2F3 (directAnnotation).
LSM14A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
LSM14A	metacluster_141.4	GLIS2 (directAnnotation).
LSM14A	transfac_pro__M06340	ZNF790 (directAnnotation).
LSM14A	metacluster_198.3	ZFP64 (directAnnotation).
LSM14A	transfac_pro__M00716	ZBTB14 (directAnnotation).
LSM14A	transfac_pro__M04893	TAF1 (directAnnotation).
LSM14A	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
LSM14A	transfac_pro__M04817	ZBTB33 (directAnnotation).
LSM14A	transfac_pro__M07387	ZBTB7A (directAnnotation).
LSM14A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
LSM14A	transfac_pro__M01783	SP2 (directAnnotation).
LSM14A	cisbp__M07938	E2F1 (directAnnotation).
LSM14A	tfdimers__MD00483	ZBTB14 (directAnnotation).
LSM14A	hdpi__GTF3C2	GTF3C2 (directAnnotation).
LSM14A	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
LSM14A	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
LSM14A	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
LSM14A	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
LSM14A	transfac_pro__M03806	ZBTB7C (directAnnotation).
LSM14A	metacluster_135.11	NR2C2 (directAnnotation).
LSM14A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
LSM14A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LSM14A	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LSM14A	cisbp__M00343	PAX6 (directAnnotation).
LSM14A	transfac_pro__M00430	E2F1 (directAnnotation).
LSM14A	transfac_pro__M12697	ZNF142 (directAnnotation).
LSM14A	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
LSM14A	transfac_pro__M00938	E2F1 (directAnnotation).
LSM14A	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."