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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LPP

Summary for LPP

Gene information	Gene symbol	LPP
	Ensembl ID	ENSG00000145012
	Entrez ID	4026
	Gene name	LIM domain containing preferred translocation partner in lipoma
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LPP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.270361	4.67e-29
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.69592	7.99e-19
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.366887	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.439297	3.66e-17
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.431583	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.518502	0.00e+00

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Expression of LPP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LPP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LPP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LPP	hsa-miR-6867-5p	99.9999	NM_001167671
LPP	hsa-miR-182-5p	99.827	NM_001167671
LPP	hsa-miR-23b-3p	99.4162	NM_001167671
LPP	hsa-miR-23a-3p	99.4162	NM_001167671
LPP	hsa-miR-4799-5p	99.4	NM_001167671
LPP	hsa-miR-551b-5p	99.2983	NM_001167671
LPP	hsa-miR-23c	99.2946	NM_001167671
LPP	hsa-miR-4795-3p	99.1906	NM_001167671
LPP	hsa-miR-190b-3p	99.0987	NM_001167671
LPP	hsa-miR-5002-5p	98.97	NM_001167671
LPP	hsa-miR-4446-5p	98.8914	NM_001167671
LPP	hsa-miR-4311	98.7554	NM_001167671
LPP	hsa-miR-656-3p	98.629	NM_001167671
LPP	hsa-miR-6809-3p	98.4869	NM_001167671
LPP	hsa-miR-548n	98.236	NM_001167671
LPP	hsa-miR-124-3p	98.1786	NM_001167671
LPP	hsa-miR-506-3p	98.1786	NM_001167671
LPP	hsa-miR-4753-3p	98.0478	NM_001167671
LPP	hsa-miR-3148	97.9339	NM_001167671
LPP	hsa-miR-590-3p	97.6951	NM_001167671
LPP	hsa-miR-4533	97.4405	NM_001167671
LPP	hsa-miR-340-5p	97.4079	NM_001167671
LPP	hsa-miR-380-3p	97.2554	NM_001167671
LPP	hsa-miR-5580-3p	97.184	NM_001167671
LPP	hsa-miR-5680	97.0773	NM_001167671
LPP	hsa-miR-6079	96.8876	NM_001167671
LPP	hsa-miR-5590-3p	96.8241	NM_001167671
LPP	hsa-miR-664a-3p	96.7221	NM_001167671
LPP	hsa-miR-142-5p	96.6311	NM_001167671
LPP	hsa-miR-942-5p	96.2949	NM_001167671
LPP	hsa-miR-3190-3p	96.288	NM_001167671
LPP	hsa-miR-4775	96.2027	NM_001167671
LPP	hsa-miR-126-5p	96.1621	NM_001167671
LPP	hsa-miR-4755-5p	95.8267	NM_001167671
LPP	hsa-miR-5006-3p	95.8267	NM_001167671
LPP	hsa-miR-3202	95.8024	NM_001167671
LPP	hsa-miR-1252-5p	95.7095	NM_001167671
LPP	hsa-miR-2392	95.6604	NM_001167671
LPP	hsa-miR-4742-5p	95.6009	NM_001167671
LPP	hsa-miR-130b-5p	95.4209	NM_001167671
LPP	hsa-miR-1253	95.1673	NM_001167671
LPP	hsa-miR-8067	94.98	NM_001167671
LPP	hsa-miR-5702	94.901	NM_001167671
LPP	hsa-miR-6508-5p	94.8587	NM_001167671
LPP	hsa-miR-4782-3p	94.6687	NM_001167671
LPP	hsa-miR-6766-3p	94.6687	NM_001167671
LPP	hsa-miR-219a-5p	94.6687	NM_001167671
LPP	hsa-miR-9983-3p	94.6616	NM_001167671
LPP	hsa-miR-6828-5p	94.4617	NM_001167671
LPP	hsa-miR-130a-5p	94.1327	NM_001167671

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Motifs and transcription factors (TFs) regulating LPP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LPP	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
LPP	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
LPP	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."