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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LMO7

Summary for LMO7

Gene information	Gene symbol	LMO7
	Ensembl ID	ENSG00000136153
	Entrez ID	4008
	Gene name	LIM domain 7
	Synonyms	FBX20\|FBXO20\|KIAA0858
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LMO7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.345824	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.829514	4.84e-36
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.426333	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.60626	0.00e+00

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Expression of LMO7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LMO7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LMO7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LMO7	hsa-miR-5692a	99.5863	NM_001306080
LMO7	hsa-miR-10527-5p	98.7177	NM_001306080
LMO7	hsa-miR-340-5p	97.5536	NM_001306080
LMO7	hsa-miR-3658	95.7826	NM_015842
LMO7	hsa-miR-3671	95.335	NM_015842
LMO7	hsa-miR-877-3p	93.7914	NM_001306080
LMO7	hsa-miR-323a-3p	93.4595	NM_015842
LMO7	hsa-miR-607	91.6716	NM_015842
LMO7	hsa-miR-4711-5p	90.6723	NM_015842
LMO7	hsa-miR-6835-3p	90.1732	NM_001306080
LMO7	hsa-miR-3529-3p	90.0186	NM_001306080
LMO7	hsa-miR-335-3p	89.8658	NM_001306080
LMO7	hsa-miR-522-3p	88.9798	NM_001306080
LMO7	hsa-miR-224-3p	88.9798	NM_001306080
LMO7	hsa-miR-4260	88.9119	NM_015842
LMO7	hsa-miR-4724-3p	88.8361	NM_001306080
LMO7	hsa-miR-20a-3p	88.1769	NM_015842
LMO7	hsa-miR-4772-3p	87.9582	NM_001306080
LMO7	hsa-miR-4686	87.956	NM_001306080
LMO7	hsa-miR-33a-3p	87.4005	NM_015842
LMO7	hsa-miR-217-5p	87.1964	NM_015842
LMO7	hsa-miR-5011-5p	86.6857	NM_015842
LMO7	hsa-miR-4490	86.3099	NM_015842
LMO7	hsa-miR-7853-5p	86.2971	NM_001306080
LMO7	hsa-miR-105-5p	86.2971	NM_001306080
LMO7	hsa-miR-5700	85.3043	NM_001306080
LMO7	hsa-miR-3160-5p	84.5588	NM_001306080
LMO7	hsa-miR-6807-3p	84.3183	NM_015842
LMO7	hsa-miR-6857-5p	83.4331	NM_015842
LMO7	hsa-miR-6083	82.798	NM_001306080
LMO7	hsa-miR-3613-3p	82.3467	NM_001306080
LMO7	hsa-miR-450a-2-3p	82.0897	NM_015842
LMO7	hsa-miR-3924	81.7718	NM_015842
LMO7	hsa-miR-548c-3p	81.5047	NM_015842
LMO7	hsa-miR-5692c	81.289	NM_015842
LMO7	hsa-miR-5692b	81.289	NM_015842
LMO7	hsa-miR-10397-3p	80.9309	NM_001306080
LMO7	hsa-miR-4692	80.1548	NM_015842

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Motifs and transcription factors (TFs) regulating LMO7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LMO7	cisbp__M00968	MTF2 (directAnnotation).
LMO7	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LMO7	metacluster_160.20	JUND; PRDM15 (directAnnotation).
LMO7	cisbp__M00341	PAX6 (directAnnotation).
LMO7	metacluster_198.3	ZFP64 (directAnnotation).
LMO7	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
LMO7	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
LMO7	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
LMO7	cisbp__M00788	ZFY (inferredBy_Orthology).
LMO7	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
LMO7	metacluster_175.1	ZNF283 (directAnnotation).
LMO7	hdpi__ZNF304	ZNF304 (directAnnotation).
LMO7	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
LMO7	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
LMO7	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
LMO7	transfac_pro__M01199	TRIM28 (directAnnotation).
LMO7	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
LMO7	metacluster_151.2	ZNF23 (directAnnotation).
LMO7	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LMO7	transfac_pro__M03806	ZBTB7C (directAnnotation).
LMO7	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LMO7	transfac_pro__M12697	ZNF142 (directAnnotation).
LMO7	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
LMO7	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
LMO7	transfac_pro__M06173	ZNF85 (directAnnotation).
LMO7	jaspar__MA1650.1	ZBTB14 (directAnnotation).
LMO7	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
LMO7	transfac_pro__M00322	MAX; MYC (directAnnotation).
LMO7	tfdimers__MD00483	ZBTB14 (directAnnotation).
LMO7	transfac_pro__M06085	ZNF26 (directAnnotation).
LMO7	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
LMO7	tfdimers__MD00364	WT1 (directAnnotation).
LMO7	transfac_pro__M04817	ZBTB33 (directAnnotation).
LMO7	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
LMO7	transfac_pro__M01253	CNOT3 (directAnnotation).
LMO7	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."