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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: LEF1

Summary for LEF1

Gene information	Gene symbol	LEF1
	Ensembl ID	ENSG00000138795
	Entrez ID	51176
	Gene name	lymphoid enhancer binding factor 1
	Synonyms	TCF10\|TCF1ALPHA\|TCF7L3
	Gene type	protein_coding
	UniProtAcc	Q9UJU2

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Dataset with differentially expressed gene: LEF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.447526	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.499501	1.98e-20
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.301447	0.00e+00

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Expression of LEF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LEF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LEF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LEF1	hsa-miR-548e-5p	99.0744	NM_001130713
LEF1	hsa-miR-1297	98.8939	NM_001130713
LEF1	hsa-miR-26b-5p	98.6178	NM_001130713
LEF1	hsa-miR-26a-5p	98.6178	NM_001130713
LEF1	hsa-miR-548p	98.2683	NM_001130713
LEF1	hsa-miR-4465	98.1225	NM_001130713
LEF1	hsa-miR-300	96.1562	NM_001130713
LEF1	hsa-miR-381-3p	96.1562	NM_001130713
LEF1	hsa-miR-4301	94.998	NM_001130714
LEF1	hsa-miR-4786-3p	94.9882	NM_001130713
LEF1	hsa-miR-511-5p	94.5767	NM_001130713
LEF1	hsa-miR-34a-5p	94.2281	NM_001130713
LEF1	hsa-miR-449a	94.2281	NM_001130713
LEF1	hsa-miR-449b-5p	93.8455	NM_001130713
LEF1	hsa-miR-34c-5p	93.8455	NM_001130713
LEF1	hsa-miR-4742-5p	93.1621	NM_001130713
LEF1	hsa-miR-7704	92.947	NM_001130713
LEF1	hsa-miR-3934-3p	92.648	NM_001130713
LEF1	hsa-miR-1468-3p	92.2752	NM_001130713
LEF1	hsa-miR-6766-3p	90.7719	NM_001130713
LEF1	hsa-miR-4782-3p	90.7719	NM_001130713
LEF1	hsa-miR-219a-5p	90.7719	NM_001130713
LEF1	hsa-miR-378g	90.0658	NM_001130713
LEF1	hsa-miR-621	88.5552	NM_001130714
LEF1	hsa-miR-452-5p	86.8403	NM_001130714
LEF1	hsa-miR-4676-3p	86.8403	NM_001130714
LEF1	hsa-miR-892c-3p	86.8403	NM_001130714
LEF1	hsa-miR-4731-5p	84.674	NM_001130713
LEF1	hsa-miR-4519	84.5443	NM_001130713
LEF1	hsa-miR-548au-3p	83.0434	NM_001130713
LEF1	hsa-miR-3119	82.1136	NM_001130713
LEF1	hsa-miR-651-3p	82.0938	NM_001130714
LEF1	hsa-miR-6842-5p	81.7822	NM_001130714
LEF1	hsa-miR-6752-5p	81.7822	NM_001130714
LEF1	hsa-miR-7110-5p	81.7822	NM_001130714
LEF1	hsa-miR-520d-5p	81.7636	NM_001130713
LEF1	hsa-miR-524-5p	81.7636	NM_001130713
LEF1	hsa-miR-548az-5p	81.5052	NM_001130713
LEF1	hsa-miR-548t-5p	81.5052	NM_001130713
LEF1	hsa-miR-5589-5p	81.3708	NM_001130713

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Motifs and transcription factors (TFs) regulating LEF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LEF1	cisbp__M02645	ETS1 (directAnnotation).
LEF1	taipale_tf_pairs__FLI1_BHLHA15_NCCGGAANCATATGN_CAP	BHLHA15; FLI1 (directAnnotation).
LEF1	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
LEF1	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
LEF1	"Etacrynic acid"	DB00903	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."