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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: KLF13

Summary for KLF13

Gene information	Gene symbol	KLF13
	Ensembl ID	ENSG00000275746
	Entrez ID	51621
	Gene name	KLF transcription factor 13
	Synonyms	BTEB3\|FKLF-2\|NSLP1\|RFLAT-1
	Gene type	protein_coding
	UniProtAcc	Q9Y2Y9

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Dataset with differentially expressed gene: KLF13

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.19656	2.39e-04
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.415482	2.20e-02
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.373454	6.42e-15
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.377284	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.483265	2.12e-11
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-1.09043	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.261468	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.980435	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.362207	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.27164	1.77e-12
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.28508	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.372413	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.301804	1.69e-21

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Expression of KLF13 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KLF13

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KLF13

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KLF13	hsa-miR-4319	98.226	NM_015995
KLF13	hsa-miR-125a-5p	97.4415	NM_015995
KLF13	hsa-miR-125b-5p	97.4415	NM_015995
KLF13	hsa-miR-1200	94.6176	NM_015995
KLF13	hsa-miR-544b	94.3764	NM_015995
KLF13	hsa-miR-7854-3p	93.3125	NM_015995
KLF13	hsa-miR-5689	92.0313	NM_015995
KLF13	hsa-miR-889-5p	91.8384	NM_015995
KLF13	hsa-miR-182-5p	91.6415	NM_015995
KLF13	hsa-miR-6728-3p	91.3779	NM_015995
KLF13	hsa-miR-6752-3p	90.5901	NM_015995
KLF13	hsa-miR-320a-3p	90.2105	NM_015995
KLF13	hsa-miR-320c	90.2105	NM_015995
KLF13	hsa-miR-4429	90.2105	NM_015995
KLF13	hsa-miR-320d	90.2105	NM_015995
KLF13	hsa-miR-320b	90.2105	NM_015995
KLF13	hsa-miR-345-3p	88.2317	NM_015995
KLF13	hsa-miR-19a-3p	87.5594	NM_015995
KLF13	hsa-miR-19b-3p	87.5594	NM_015995
KLF13	hsa-miR-4251	86.6282	NM_015995
KLF13	hsa-miR-6748-5p	83.8342	NM_015995
KLF13	hsa-miR-6721-5p	83.138	NM_015995
KLF13	hsa-miR-7856-5p	82.3718	NM_015995
KLF13	hsa-miR-7162-3p	82.0817	NM_015995
KLF13	hsa-miR-497-3p	81.8883	NM_015995
KLF13	hsa-miR-15b-3p	80.7985	NM_015995
KLF13	hsa-miR-6073	80.0945	NM_015995
KLF13	hsa-miR-3680-3p	80.0675	NM_015995

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Motifs and transcription factors (TFs) regulating KLF13

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KLF13	hdpi__ENO1	ENO1 (directAnnotation).
KLF13	transfac_pro__M03849	SOX4 (directAnnotation).
KLF13	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
KLF13	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
KLF13	hdpi__TIMELESS	TIMELESS (directAnnotation).
KLF13	transfac_pro__M06340	ZNF790 (directAnnotation).
KLF13	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
KLF13	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
KLF13	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
KLF13	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
KLF13	cisbp__M00341	PAX6 (directAnnotation).
KLF13	metacluster_198.3	ZFP64 (directAnnotation).
KLF13	hdpi__ZNF304	ZNF304 (directAnnotation).
KLF13	transfac_pro__M01199	TRIM28 (directAnnotation).
KLF13	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KLF13	transfac_pro__M03806	ZBTB7C (directAnnotation).
KLF13	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KLF13	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
KLF13	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
KLF13	transfac_pro__M07483	CXXC1 (directAnnotation).
KLF13	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
KLF13	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
KLF13	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
KLF13	transfac_pro__M01253	CNOT3 (directAnnotation).
KLF13	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
KLF13	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
KLF13	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
KLF13	transfac_pro__M07310	SP5 (directAnnotation).
KLF13	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
KLF13	transfac_pro__M04817	ZBTB33 (directAnnotation).
KLF13	transfac_pro__M12697	ZNF142 (directAnnotation).
KLF13	transfac_pro__M04916	TAF1 (directAnnotation).
KLF13	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
KLF13	tfdimers__MD00483	ZBTB14 (directAnnotation).
KLF13	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
KLF13	transfac_pro__M01303	SP1 (directAnnotation).
KLF13	metacluster_143.13	ZBTB7A (directAnnotation).
KLF13	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
KLF13	transfac_pro__M07329	SP7 (directAnnotation).
KLF13	jaspar__MA0079.5	SP1 (directAnnotation).
KLF13	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
KLF13	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
KLF13	cisbp__M07938	E2F1 (directAnnotation).
KLF13	transfac_pro__M06237	ZNF846 (directAnnotation).
KLF13	transfac_pro__M06766	ZNF835 (directAnnotation).
KLF13	tfdimers__MD00016	MYCN (directAnnotation).
KLF13	taipale__IRF7_DBD_RAANCGAAAWTCGNTTY_repr	IRF7 (directAnnotation).
KLF13	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).
KLF13	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
KLF13	metacluster_195.2	up	Malignant cells	GSE140440	NA
KLF13	hocomoco__KLF13_HUMAN.H11MO.0.D	up	Malignant cells	GSE140440	NA
KLF13	transfac_pro__M07461	up	Malignant cells	GSE140440	NA
KLF13	metacluster_170.2	up	Malignant cells	GSE140440	NA
KLF13	metacluster_163.1	up	Malignant cells	GSE161801_IMiD	pre
KLF13	hocomoco__KLF13_HUMAN.H11MO.0.D	down	Erythrocytes	GSE164551	NA
KLF13	metacluster_170.2	down	Malignant cells	GSE189460	pre
KLF13	metacluster_195.2	down	Malignant cells	GSE189460	pre
KLF13	hocomoco__KLF13_HUMAN.H11MO.0.D	down	Erythrocytes	GSE199333	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."