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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KDM6A

Summary for KDM6A

Gene information	Gene symbol	KDM6A
	Ensembl ID	ENSG00000147050
	Entrez ID	7403
	Gene name	lysine demethylase 6A
	Synonyms	UTX
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KDM6A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.28487	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.257913	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.260329	4.50e-42

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Expression of KDM6A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KDM6A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KDM6A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KDM6A	hsa-miR-5011-5p	100	NM_001291415
KDM6A	hsa-miR-190a-3p	99.9893	NM_001291415
KDM6A	hsa-miR-4719	98.8847	NM_001291415
KDM6A	hsa-miR-3163	97.3536	NM_001291415
KDM6A	hsa-let-7f-1-3p	97.1924	NM_001291415
KDM6A	hsa-miR-98-3p	97.1924	NM_001291415
KDM6A	hsa-let-7a-3p	97.1924	NM_001291415
KDM6A	hsa-let-7b-3p	97.1924	NM_001291415
KDM6A	hsa-miR-23a-3p	96.1557	NM_001291415
KDM6A	hsa-miR-23b-3p	96.1557	NM_001291415
KDM6A	hsa-miR-23c	96.1557	NM_001291415
KDM6A	hsa-miR-3942-5p	96.0751	NM_001291415
KDM6A	hsa-miR-4703-5p	96.0751	NM_001291415
KDM6A	hsa-miR-4328	95.5287	NM_001291415
KDM6A	hsa-miR-7150	94.9604	NM_001291415
KDM6A	hsa-miR-539-5p	94.149	NM_001291415
KDM6A	hsa-miR-4282	94.0907	NM_001291415
KDM6A	hsa-miR-1-5p	93.9486	NM_001291415
KDM6A	hsa-miR-5003-3p	93.6132	NM_001291415
KDM6A	hsa-miR-758-3p	93.4473	NM_001291415
KDM6A	hsa-miR-1277-5p	93.1282	NM_001291415
KDM6A	hsa-miR-466	92.8387	NM_001291415
KDM6A	hsa-miR-224-5p	92.6576	NM_001291415
KDM6A	hsa-miR-875-3p	92.3069	NM_001291415
KDM6A	hsa-miR-498-5p	91.9234	NM_001291415
KDM6A	hsa-miR-199b-3p	90.6903	NM_001291415
KDM6A	hsa-miR-3129-5p	90.6903	NM_001291415
KDM6A	hsa-miR-199a-3p	90.6903	NM_001291415
KDM6A	hsa-miR-300	90.6193	NM_001291415
KDM6A	hsa-miR-381-3p	90.6193	NM_001291415
KDM6A	hsa-miR-3140-5p	90.3594	NM_001291415
KDM6A	hsa-miR-4687-3p	89.7248	NM_001291415
KDM6A	hsa-miR-548e-5p	89.1688	NM_001291415
KDM6A	hsa-miR-513a-3p	88.9109	NM_001291415
KDM6A	hsa-miR-513c-3p	88.9109	NM_001291415
KDM6A	hsa-miR-153-3p	88.8594	NM_001291415
KDM6A	hsa-miR-5006-5p	88.2995	NM_001291415
KDM6A	hsa-miR-3972	88.2246	NM_001291415
KDM6A	hsa-miR-1202	88.2246	NM_001291415
KDM6A	hsa-miR-936	88.0333	NM_001291415
KDM6A	hsa-miR-3914	88.0265	NM_001291415
KDM6A	hsa-miR-4666a-3p	87.7844	NM_001291415
KDM6A	hsa-miR-6719-3p	87.726	NM_001291415
KDM6A	hsa-miR-1299	87.6158	NM_001291415
KDM6A	hsa-miR-656-3p	87.5061	NM_001291415
KDM6A	hsa-miR-3606-3p	87.2238	NM_001291415
KDM6A	hsa-miR-4690-3p	87.027	NM_001291415
KDM6A	hsa-miR-5685	87.027	NM_001291415
KDM6A	hsa-miR-7159-3p	86.9733	NM_001291415
KDM6A	hsa-miR-4482-3p	86.9733	NM_001291415

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Motifs and transcription factors (TFs) regulating KDM6A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KDM6A	transfac_pro__M12694	ZFP14 (directAnnotation).
KDM6A	transfac_pro__M01253	CNOT3 (directAnnotation).
KDM6A	transfac_pro__M04617	ZBTB7A (directAnnotation).
KDM6A	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
KDM6A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
KDM6A	transfac_pro__M02090	E2F4 (directAnnotation).
KDM6A	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
KDM6A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
KDM6A	transfac_pro__M07437	ZBTB2 (directAnnotation).
KDM6A	transfac_pro__M01861	ATF1 (directAnnotation).
KDM6A	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
KDM6A	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
KDM6A	hdpi__TIMELESS	TIMELESS (directAnnotation).
KDM6A	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
KDM6A	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
KDM6A	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
KDM6A	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
KDM6A	transfac_pro__M06208	ZNF460 (directAnnotation).
KDM6A	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
KDM6A	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
KDM6A	transfac_pro__M06545	ZNF485 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."