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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KDM2A

Summary for KDM2A

Gene information	Gene symbol	KDM2A
	Ensembl ID	ENSG00000173120
	Entrez ID	22992
	Gene name	lysine demethylase 2A
	Synonyms	CXXC8\|DKFZP434M1735\|FBL11\|FBL7\|FBXL11\|FLJ00115\|JHDM1A\|KIAA1004\|LILINA
	Gene type	protein_coding
	UniProtAcc	Q9Y2K7

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Dataset with differentially expressed gene: KDM2A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.297554	7.33e-22
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.291808	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.426792	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.329637	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.471317	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.423888	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.351034	3.18e-37

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Expression of KDM2A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KDM2A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KDM2A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KDM2A	hsa-miR-5011-5p	99.8813	NM_001256405
KDM2A	hsa-miR-190a-3p	99.844	NM_001256405
KDM2A	hsa-miR-4443	98.0173	NM_012308
KDM2A	hsa-miR-6832-3p	97.1103	NM_012308
KDM2A	hsa-miR-548ap-3p	96.9305	NM_012308
KDM2A	hsa-miR-548aa	96.9305	NM_012308
KDM2A	hsa-miR-548t-3p	96.9305	NM_012308
KDM2A	hsa-miR-186-3p	96.5398	NM_001256405
KDM2A	hsa-miR-3065-5p	96.3967	NM_001256405
KDM2A	hsa-miR-519b-3p	95.2282	NM_001256405
KDM2A	hsa-miR-519c-3p	95.2282	NM_001256405
KDM2A	hsa-miR-519a-3p	95.2282	NM_001256405
KDM2A	hsa-miR-6875-3p	93.559	NM_012308
KDM2A	hsa-miR-6081	93.4507	NM_012308
KDM2A	hsa-miR-130a-3p	93.0801	NM_012308
KDM2A	hsa-miR-301a-3p	93.0801	NM_012308
KDM2A	hsa-miR-130b-3p	93.0801	NM_012308
KDM2A	hsa-miR-454-3p	93.0801	NM_012308
KDM2A	hsa-miR-301b-3p	93.0801	NM_012308
KDM2A	hsa-miR-3666	93.0801	NM_012308
KDM2A	hsa-miR-4295	93.0801	NM_012308
KDM2A	hsa-miR-4291	92.9783	NM_012308
KDM2A	hsa-miR-4437	92.9015	NM_012308
KDM2A	hsa-miR-518c-5p	92.859	NM_012308
KDM2A	hsa-miR-650	92.7653	NM_012308
KDM2A	hsa-miR-3612	92.7653	NM_012308
KDM2A	hsa-miR-6731-5p	92.5883	NM_001256405
KDM2A	hsa-miR-8085	92.5883	NM_001256405
KDM2A	hsa-miR-3617-3p	91.5374	NM_001256405
KDM2A	hsa-miR-7155-3p	91.2822	NM_012308
KDM2A	hsa-miR-585-5p	91.2023	NM_012308
KDM2A	hsa-miR-656-3p	91.0741	NM_001256405
KDM2A	hsa-miR-4672	90.7373	NM_012308
KDM2A	hsa-miR-3941	90.7373	NM_012308
KDM2A	hsa-miR-3176	90.5389	NM_012308
KDM2A	hsa-miR-765	90.4237	NM_001256405
KDM2A	hsa-miR-5003-5p	90.4051	NM_012308
KDM2A	hsa-miR-3922-3p	90.3067	NM_012308
KDM2A	hsa-miR-511-5p	89.7544	NM_001256405
KDM2A	hsa-miR-214-5p	89.6721	NM_012308
KDM2A	hsa-miR-1913	89.2483	NM_012308
KDM2A	hsa-miR-4534	89.1529	NM_012308
KDM2A	hsa-miR-3613-3p	89.1149	NM_001256405
KDM2A	hsa-miR-518a-5p	88.7809	NM_012308
KDM2A	hsa-miR-527	88.7809	NM_012308
KDM2A	hsa-miR-216b-3p	88.5394	NM_001256405
KDM2A	hsa-miR-2278	88.5224	NM_001256405
KDM2A	hsa-miR-4468	88.4688	NM_012308
KDM2A	hsa-miR-6756-3p	88.464	NM_012308
KDM2A	hsa-miR-3127-3p	88.464	NM_012308

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Motifs and transcription factors (TFs) regulating KDM2A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KDM2A	transfac_pro__M07310	SP5 (directAnnotation).
KDM2A	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
KDM2A	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
KDM2A	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
KDM2A	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
KDM2A	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
KDM2A	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
KDM2A	transfac_pro__M01253	CNOT3 (directAnnotation).
KDM2A	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
KDM2A	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
KDM2A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
KDM2A	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
KDM2A	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
KDM2A	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
KDM2A	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
KDM2A	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
KDM2A	transfac_pro__M04817	ZBTB33 (directAnnotation).
KDM2A	transfac_pro__M12697	ZNF142 (directAnnotation).
KDM2A	tfdimers__MD00364	WT1 (directAnnotation).
KDM2A	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
KDM2A	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
KDM2A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
KDM2A	tfdimers__MD00483	ZBTB14 (directAnnotation).
KDM2A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
KDM2A	transfac_pro__M01303	SP1 (directAnnotation).
KDM2A	metacluster_143.13	ZBTB7A (directAnnotation).
KDM2A	transfac_pro__M07387	ZBTB7A (directAnnotation).
KDM2A	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
KDM2A	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
KDM2A	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
KDM2A	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
KDM2A	transfac_pro__M07329	SP7 (directAnnotation).
KDM2A	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
KDM2A	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."