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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KCNAB2

Summary for KCNAB2

Gene information	Gene symbol	KCNAB2
	Ensembl ID	ENSG00000069424
	Entrez ID	8514
	Gene name	potassium voltage-gated channel subfamily A regulatory beta subunit 2
	Synonyms	AKR6A5\|HKvbeta2.1\|HKvbeta2.2\|KCNA2B
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KCNAB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.257212	3.36e-06
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.255927	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	CD8+ T cells	0.302575	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	NK cells	0.364523	0.00e+00
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.355696	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.291884	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.942866	0.00e+00

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Expression of KCNAB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KCNAB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KCNAB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KCNAB2	hsa-miR-4483	97.4656	NM_001199861
KCNAB2	hsa-miR-4447	97.1163	NM_001199861
KCNAB2	hsa-miR-1293	96.158	NM_001199861
KCNAB2	hsa-miR-661	94.2236	NM_001199861
KCNAB2	hsa-miR-194-3p	94.1914	NM_001199861
KCNAB2	hsa-miR-6756-5p	93.4807	NM_001199861
KCNAB2	hsa-miR-6766-5p	92.7159	NM_001199861
KCNAB2	hsa-miR-587	92.1505	NM_001199860
KCNAB2	hsa-miR-1913	91.074	NM_001199861
KCNAB2	hsa-miR-210-5p	91.0455	NM_001199860
KCNAB2	hsa-miR-4472	90.8312	NM_001199861
KCNAB2	hsa-miR-6752-3p	90.6018	NM_001199860
KCNAB2	hsa-miR-486-3p	87.6217	NM_001199861
KCNAB2	hsa-miR-18a-3p	85.1656	NM_001199860
KCNAB2	hsa-miR-10398-5p	82.6103	NM_001199861
KCNAB2	hsa-miR-6848-5p	82.4093	NM_001199861
KCNAB2	hsa-miR-6846-5p	82.4093	NM_001199861
KCNAB2	hsa-miR-8085	81.5917	NM_001199861
KCNAB2	hsa-miR-4481	80.8387	NM_001199861
KCNAB2	hsa-miR-3667-3p	80.5829	NM_001199860

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Motifs and transcription factors (TFs) regulating KCNAB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KCNAB2	transfac_pro__M05533	ZNF589 (directAnnotation).
KCNAB2	jaspar__MA1645.1	NKX2-2 (directAnnotation).
KCNAB2	metacluster_28.3	NKX2-1 (directAnnotation). NKX2-1; NKX2-2; NKX2-2; NKX2-5 (inferredBy_Orthology).
KCNAB2	transfac_pro__M05939	ZNF471 (directAnnotation).
KCNAB2	transfac_pro__M05967	ZFP30 (directAnnotation).
KCNAB2	kznf__ZNF45_Imbeault2017_RP_ChIP-seq	ZNF45 (directAnnotation).
KCNAB2	tfdimers__MD00174	PDX1; STAT6 (directAnnotation).
KCNAB2	tfdimers__MD00180	MAFA (directAnnotation).
KCNAB2	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
KCNAB2	tfdimers__MD00405	HLTF; IRF1 (directAnnotation).
KCNAB2	tfdimers__MD00504	ELF1; NFIA; NFIC (directAnnotation).
KCNAB2	metacluster_20.3	BARHL2; BARHL2 (directAnnotation).
KCNAB2	transfac_pro__M01119	ZBTB33 (directAnnotation).
KCNAB2	transfac_public__M00271	RUNX1 (directAnnotation).
KCNAB2	metacluster_147.4	SMAD2; SMAD3; SMAD4; SMAD4 (directAnnotation).
KCNAB2	transfac_pro__M06150	ZNF81 (directAnnotation).
KCNAB2	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANNRTMAAYA_CAP_repr	ELK1; FOXI1 (directAnnotation).
KCNAB2	tfdimers__MD00528	NEUROD1 (directAnnotation).
KCNAB2	transfac_pro__M06849	ZNF528 (directAnnotation).
KCNAB2	metacluster_90.5	NR5A2; NR5A2 (directAnnotation). ESRRB; NR5A1; NR5A1; NR5A1; NR5A2; NR5A2; NR5A2 (inferredBy_Orthology).
KCNAB2	kznf__ZNF790_Imbeault2017_RP_ChIP-seq	ZNF790 (directAnnotation).
KCNAB2	metacluster_79.10	ZNF33A (directAnnotation).
KCNAB2	cisbp__M07803	MYC (directAnnotation).
KCNAB2	jaspar__MA1106.1	HIF1A (directAnnotation).
KCNAB2	cisbp__M05832	MAX (directAnnotation).
KCNAB2	taipale_tf_pairs__MYCL2_SCACGTGS_HT	MYCLP1 (directAnnotation).
KCNAB2	transfac_pro__M06313	ZNF678 (directAnnotation).
KCNAB2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
KCNAB2	transfac_pro__M06854	ZNF600 (directAnnotation).
KCNAB2	jaspar__MA0684.2	RUNX3 (directAnnotation).
KCNAB2	transfac_pro__M02113	POU2AF1 (directAnnotation).
KCNAB2	metacluster_10.45	MXD3 (directAnnotation).
KCNAB2	metacluster_10.46	MAX (inferredBy_Orthology).
KCNAB2	tfdimers__MD00048	CDX2; IKZF1 (directAnnotation).
KCNAB2	c2h2_zfs__M0404	ZFP3 (inferredBy_Orthology).
KCNAB2	taipale_tf_pairs__GCM1_FIGLA_CAGCTGNNNNNNNNTGCGGG_CAP	FIGLA; GCM1 (directAnnotation).
KCNAB2	kznf__ZNF184_Schmitges2016_RCADE	ZNF184 (directAnnotation).
KCNAB2	homer__NVCACGTG_NPAS	NPAS2 (inferredBy_Orthology).
KCNAB2	metacluster_130.6	ZFP28 (directAnnotation).
KCNAB2	hocomoco__PO5F1_HUMAN.H11MO.1.A	POU5F1 (directAnnotation).
KCNAB2	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
KCNAB2	taipale_tf_pairs__ETV2_HOXB13_NCCGGAAGTYRTAAAN_CAP	ETV2; HOXB13 (directAnnotation).
KCNAB2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
KCNAB2	hdpi__FLI1	FLI1 (directAnnotation).
KCNAB2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
KCNAB2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
KCNAB2	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
KCNAB2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
KCNAB2	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
KCNAB2	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."