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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KAT6A

Summary for KAT6A

Gene information	Gene symbol	KAT6A
	Ensembl ID	ENSG00000083168
	Entrez ID	7994
	Gene name	lysine acetyltransferase 6A
	Synonyms	MOZ\|MYST3\|RUNXBP2\|ZC2HC6A\|ZNF220
	Gene type	protein_coding
	UniProtAcc	Q92794

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Dataset with differentially expressed gene: KAT6A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.252146	8.94e-10
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.330635	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.272643	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.491049	0.00e+00

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Expression of KAT6A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KAT6A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
KAT6A	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating KAT6A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KAT6A	hsa-miR-5011-5p	100	NM_006766
KAT6A	hsa-miR-6867-5p	100	NM_006766
KAT6A	hsa-miR-190a-3p	100	NM_006766
KAT6A	hsa-miR-4311	99.2832	NM_006766
KAT6A	hsa-miR-3133	99.0472	NM_006766
KAT6A	hsa-miR-3529-3p	98.7603	NM_006766
KAT6A	hsa-miR-4428	98.1827	NM_006766
KAT6A	hsa-miR-583	97.9609	NM_006766
KAT6A	hsa-miR-3662	97.9108	NM_006766
KAT6A	hsa-miR-12127	97.7249	NM_006766
KAT6A	hsa-miR-548av-5p	97.7122	NM_006766
KAT6A	hsa-miR-548k	97.7122	NM_006766
KAT6A	hsa-miR-3123	97.1914	NM_006766
KAT6A	hsa-miR-139-5p	97.0156	NM_006766
KAT6A	hsa-miR-206	96.9879	NM_006766
KAT6A	hsa-miR-520d-5p	96.8988	NM_006766
KAT6A	hsa-miR-524-5p	96.8988	NM_006766
KAT6A	hsa-miR-8054	96.8758	NM_006766
KAT6A	hsa-miR-6071	96.5637	NM_006766
KAT6A	hsa-miR-1-3p	96.0815	NM_006766
KAT6A	hsa-miR-410-3p	95.8144	NM_006766
KAT6A	hsa-miR-1283	95.7842	NM_006766
KAT6A	hsa-miR-494-3p	95.7706	NM_006766
KAT6A	hsa-miR-6783-5p	95.5722	NM_006766
KAT6A	hsa-miR-613	95.3513	NM_006766
KAT6A	hsa-miR-520e-5p	95.2188	NM_006766
KAT6A	hsa-miR-5692c	95.0842	NM_006766
KAT6A	hsa-miR-5692b	95.0842	NM_006766
KAT6A	hsa-miR-4306	95.057	NM_006766
KAT6A	hsa-miR-4426	95.0095	NM_006766
KAT6A	hsa-miR-4662b	94.941	NM_006766
KAT6A	hsa-miR-4647	94.941	NM_006766
KAT6A	hsa-miR-3163	94.8436	NM_006766
KAT6A	hsa-miR-5087	94.7233	NM_006766
KAT6A	hsa-miR-3148	94.6918	NM_006766
KAT6A	hsa-miR-7112-3p	94.5204	NM_001305878
KAT6A	hsa-miR-185-5p	94.4747	NM_006766
KAT6A	hsa-miR-5010-3p	94.4213	NM_006766
KAT6A	hsa-miR-577	94.1398	NM_006766
KAT6A	hsa-miR-143-3p	93.8804	NM_006766
KAT6A	hsa-miR-4770	93.8804	NM_006766
KAT6A	hsa-miR-203a-3p	93.7094	NM_006766
KAT6A	hsa-miR-4708-5p	93.5639	NM_006766
KAT6A	hsa-miR-6088	93.5639	NM_006766
KAT6A	hsa-miR-4653-5p	93.0141	NM_006766
KAT6A	hsa-miR-3921	93.0141	NM_006766
KAT6A	hsa-miR-558	92.6906	NM_006766
KAT6A	hsa-miR-3191-5p	92.6704	NM_006766
KAT6A	hsa-miR-2113	92.6472	NM_006766
KAT6A	hsa-miR-5681a	92.4614	NM_006766

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Motifs and transcription factors (TFs) regulating KAT6A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KAT6A	cisbp__M01863	ZNF711 (inferredBy_Orthology).
KAT6A	transfac_pro__M07310	SP5 (directAnnotation).
KAT6A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
KAT6A	transfac_pro__M00938	E2F1 (directAnnotation).
KAT6A	transfac_pro__M04893	TAF1 (directAnnotation).
KAT6A	transfac_pro__M04817	ZBTB33 (directAnnotation).
KAT6A	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
KAT6A	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
KAT6A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
KAT6A	tfdimers__MD00483	ZBTB14 (directAnnotation).
KAT6A	transfac_pro__M01303	SP1 (directAnnotation).
KAT6A	transfac_pro__M07387	ZBTB7A (directAnnotation).
KAT6A	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
KAT6A	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
KAT6A	transfac_pro__M00665	SP3 (directAnnotation).
KAT6A	transfac_pro__M02898	SMAD3 (directAnnotation).
KAT6A	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
KAT6A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
KAT6A	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
KAT6A	transfac_pro__M07329	SP7 (directAnnotation).
KAT6A	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
KAT6A	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
KAT6A	transfac_pro__M02089	E2F3 (directAnnotation).
KAT6A	cisbp__M07938	E2F1 (directAnnotation).
KAT6A	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
KAT6A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
KAT6A	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."