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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: JADE1

Summary for JADE1

Gene information	Gene symbol	JADE1
	Ensembl ID	ENSG00000077684
	Entrez ID	79960
	Gene name	jade family PHD finger 1
	Synonyms	JADE-1\|PHF17
	Gene type	protein_coding
	UniProtAcc	Q6IE81

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Dataset with differentially expressed gene: JADE1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.411193	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.294317	0.00e+00

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Expression of JADE1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to JADE1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating JADE1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
JADE1	hsa-miR-875-3p	99.0367	NM_001287437
JADE1	hsa-miR-5582-5p	97.6454	NM_001287437
JADE1	hsa-miR-137-3p	97.4267	NM_001287437
JADE1	hsa-miR-548aw	96.8756	NM_001287437
JADE1	hsa-miR-3065-5p	96.3922	NM_001287439
JADE1	hsa-miR-2113	95.8998	NM_001287437
JADE1	hsa-miR-6830-5p	95.3317	NM_001287437
JADE1	hsa-miR-9983-3p	95.33	NM_001287437
JADE1	hsa-miR-7159-5p	95.1309	NM_001287439
JADE1	hsa-miR-8485	94.6868	NM_001287441
JADE1	hsa-miR-5010-3p	94.6499	NM_001287439
JADE1	hsa-miR-129-5p	94.4899	NM_001287437
JADE1	hsa-miR-3148	94.483	NM_001287439
JADE1	hsa-miR-6128	94.3217	NM_001287437
JADE1	hsa-miR-507	94.2905	NM_001287441
JADE1	hsa-miR-3613-3p	94.0117	NM_001287437
JADE1	hsa-miR-557	93.9569	NM_001287441
JADE1	hsa-miR-12123	93.9329	NM_001287439
JADE1	hsa-miR-4714-3p	93.3659	NM_001287437
JADE1	hsa-miR-888-5p	93.269	NM_001287439
JADE1	hsa-miR-454-3p	92.9126	NM_001287437
JADE1	hsa-miR-8087	92.8891	NM_001287437
JADE1	hsa-miR-124-3p	92.4304	NM_001287437
JADE1	hsa-miR-506-3p	92.4304	NM_001287437
JADE1	hsa-miR-218-1-3p	92.2288	NM_001287437
JADE1	hsa-miR-4255	91.8388	NM_001287437
JADE1	hsa-miR-671-5p	91.6895	NM_001287439
JADE1	hsa-miR-342-3p	91.6824	NM_001287437
JADE1	hsa-miR-6752-3p	91.4961	NM_001287437
JADE1	hsa-miR-4457	91.178	NM_001287437
JADE1	hsa-miR-4295	91.1647	NM_001287437
JADE1	hsa-miR-130b-3p	91.1647	NM_001287437
JADE1	hsa-miR-3666	91.1647	NM_001287437
JADE1	hsa-miR-130a-3p	91.1647	NM_001287437
JADE1	hsa-miR-301b-3p	91.1647	NM_001287437
JADE1	hsa-miR-301a-3p	91.1647	NM_001287437
JADE1	hsa-miR-4721	90.8875	NM_001287437
JADE1	hsa-miR-670-3p	90.3808	NM_001287439
JADE1	hsa-miR-4684-5p	90.3238	NM_001287437
JADE1	hsa-miR-4676-3p	90.2798	NM_001287441
JADE1	hsa-miR-4680-3p	89.8468	NM_001287439
JADE1	hsa-miR-520b-5p	89.4122	NM_001287437
JADE1	hsa-miR-519a-2-5p	89.4122	NM_001287437
JADE1	hsa-miR-892c-3p	89.3177	NM_001287441
JADE1	hsa-miR-452-5p	89.2847	NM_001287441
JADE1	hsa-miR-1468-3p	89.1691	NM_001287439
JADE1	hsa-miR-205-5p	89.1267	NM_001287437
JADE1	hsa-miR-1299	89.0558	NM_001287437
JADE1	hsa-miR-3934-3p	88.9756	NM_001287437
JADE1	hsa-miR-5586-5p	88.5446	NM_001287439

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Motifs and transcription factors (TFs) regulating JADE1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
JADE1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
JADE1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
JADE1	metacluster_191.5	SPDEF (inferredBy_Orthology).
JADE1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
JADE1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
JADE1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
JADE1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
JADE1	transfac_pro__M01199	TRIM28 (directAnnotation).
JADE1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
JADE1	hdpi__ELF2	ELF2 (directAnnotation).
JADE1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."