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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ITGA4

Summary for ITGA4

Gene information	Gene symbol	ITGA4
	Ensembl ID	ENSG00000115232
	Entrez ID	3676
	Gene name	integrin subunit alpha 4
	Synonyms	CD49D
	Gene type	protein_coding
	UniProtAcc	P13612

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Dataset with differentially expressed gene: ITGA4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.352321	1.71e-41
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.532804	4.58e-09
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.436363	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.384663	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.659541	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.472819	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.323333	4.42e-18
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.26036	1.66e-05
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.469711	2.49e-28
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.652111	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.252179	9.29e-24
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD4+ T cells	0.310639	2.66e-27
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	Mono/Macro	-0.280822	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.368418	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	0.357326	4.13e-12
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.468946	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.337092	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.34651	3.26e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.722098	1.00e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.298506	7.45e-07
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	-0.393573	8.75e-03

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Expression of ITGA4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ITGA4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ITGA4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ITGA4	hsa-miR-513a-3p	97.8305	NM_000885
ITGA4	hsa-miR-513c-3p	97.8305	NM_000885
ITGA4	hsa-miR-6833-3p	97.6404	NM_000885
ITGA4	hsa-miR-4768-5p	97.6027	NM_000885
ITGA4	hsa-miR-1290	97.4572	NM_001316312
ITGA4	hsa-miR-526b-3p	97.3074	NM_000885
ITGA4	hsa-miR-20a-5p	97.1268	NM_000885
ITGA4	hsa-miR-106b-5p	97.1268	NM_000885
ITGA4	hsa-miR-3606-3p	97.0639	NM_000885
ITGA4	hsa-miR-6873-3p	96.7388	NM_000885
ITGA4	hsa-miR-519d-3p	96.3871	NM_000885
ITGA4	hsa-miR-106a-5p	96.3871	NM_000885
ITGA4	hsa-miR-20b-5p	96.3871	NM_000885
ITGA4	hsa-miR-17-5p	96.3871	NM_000885
ITGA4	hsa-miR-93-5p	96.3871	NM_000885
ITGA4	hsa-miR-548ah-5p	95.3243	NM_000885
ITGA4	hsa-miR-3609	95.3243	NM_000885
ITGA4	hsa-miR-4796-3p	95.2402	NM_000885
ITGA4	hsa-miR-5696	94.3479	NM_000885
ITGA4	hsa-miR-12125	94.0411	NM_000885
ITGA4	hsa-miR-664b-3p	93.9904	NM_000885
ITGA4	hsa-miR-579-3p	93.9904	NM_000885
ITGA4	hsa-miR-578	93.0004	NM_000885
ITGA4	hsa-miR-6871-3p	92.9611	NM_001316312
ITGA4	hsa-miR-5688	92.6845	NM_000885
ITGA4	hsa-miR-12124	92.5407	NM_000885
ITGA4	hsa-miR-369-3p	91.0369	NM_000885
ITGA4	hsa-miR-495-3p	90.8811	NM_000885
ITGA4	hsa-miR-7-1-3p	90.789	NM_000885
ITGA4	hsa-miR-7-2-3p	90.789	NM_000885
ITGA4	hsa-miR-380-3p	90.1107	NM_001316312
ITGA4	hsa-miR-5683	90.021	NM_000885
ITGA4	hsa-miR-1843	89.7778	NM_000885
ITGA4	hsa-miR-4802-5p	89.7778	NM_000885
ITGA4	hsa-miR-3133	89.7628	NM_000885
ITGA4	hsa-miR-4735-5p	89.5952	NM_000885
ITGA4	hsa-miR-5004-3p	89.4197	NM_000885
ITGA4	hsa-miR-3925-3p	88.9628	NM_000885
ITGA4	hsa-miR-8063	88.102	NM_000885
ITGA4	hsa-miR-335-3p	87.6916	NM_000885
ITGA4	hsa-miR-340-5p	87.5764	NM_000885
ITGA4	hsa-miR-7161-3p	87.192	NM_000885
ITGA4	hsa-miR-9-5p	86.8668	NM_000885
ITGA4	hsa-miR-122b-5p	86.7904	NM_000885
ITGA4	hsa-miR-7-5p	86.6773	NM_000885
ITGA4	hsa-miR-5189-3p	86.6703	NM_001316312
ITGA4	hsa-miR-3158-3p	85.0714	NM_000885
ITGA4	hsa-miR-590-3p	84.4787	NM_000885
ITGA4	hsa-miR-4729	82.9451	NM_000885
ITGA4	hsa-miR-576-5p	82.5249	NM_000885

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Motifs and transcription factors (TFs) regulating ITGA4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ITGA4	metacluster_9.47	PAX7 (inferredBy_Orthology).
ITGA4	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
ITGA4	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
ITGA4	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ITGA4	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
ITGA4	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
ITGA4	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
ITGA4	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
ITGA4	metacluster_141.2	E2F2; E2F3 (directAnnotation).
ITGA4	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
ITGA4	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ITGA4	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
ITGA4	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
ITGA4	metacluster_178.16	ZNF660; ZNF660 (directAnnotation).
ITGA4	transfac_pro__M06239	ZNF844 (directAnnotation).
ITGA4	transfac_pro__M06660	ZNF670 (directAnnotation).
ITGA4	transfac_pro__M06273	ZNF766 (directAnnotation).
ITGA4	transfac_pro__M00655	ETV4 (directAnnotation).
ITGA4	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
ITGA4	homer__ACAGGATGTGGT_ETS_RUNX	RUNX1 (directAnnotation).
ITGA4	transfac_pro__M06920	ZNF256 (directAnnotation).
ITGA4	jaspar__MA0136.3	ELF5 (inferredBy_Orthology).
ITGA4	metacluster_178.20	ZKSCAN1 (directAnnotation). ZKSCAN1 (inferredBy_Orthology).
ITGA4	transfac_pro__M05948	ZNF582 (directAnnotation).
ITGA4	taipale_tf_pairs__GCM1_FOXI1_RTMAACATRNGGGN_CAP_repr	FOXI1; GCM1 (directAnnotation).
ITGA4	transfac_pro__M06484	ZNF683 (directAnnotation).
ITGA4	metacluster_144.10	ZNF100 (directAnnotation).
ITGA4	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
ITGA4	tfdimers__MD00046	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6; SMAD4 (directAnnotation).
ITGA4	tfdimers__MD00165	CRX; FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND (directAnnotation).
ITGA4	hdpi__NRL	NRL (directAnnotation).
ITGA4	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ITGA4	hdpi__FEZF2	FEZF2 (directAnnotation).
ITGA4	transfac_pro__M07310	SP5 (directAnnotation).
ITGA4	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ITGA4	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ITGA4	hdpi__HTATIP2	HTATIP2 (directAnnotation).
ITGA4	hdpi__ZNF304	ZNF304 (directAnnotation).
ITGA4	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
ITGA4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ITGA4	cisbp__M07938	E2F1 (directAnnotation).
ITGA4	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ITGA4	tfdimers__MD00483	ZBTB14 (directAnnotation).
ITGA4	transfac_pro__M12697	ZNF142 (directAnnotation).
ITGA4	transfac_pro__M00716	ZBTB14 (directAnnotation).
ITGA4	transfac_pro__M03806	ZBTB7C (directAnnotation).
ITGA4	transfac_pro__M04893	TAF1 (directAnnotation).
ITGA4	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ITGA4	transfac_pro__M04916	TAF1 (directAnnotation).
ITGA4	jaspar__MA1650.1	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ITGA4	"ATL1102"	DB04997	small molecule
ITGA4	"CDP323"	DB05092	small molecule
ITGA4	"Natalizumab"	DB00108	biotech
ITGA4	"R1295"	DB05122	small molecule
ITGA4	"R411"	DB05468	small molecule
ITGA4	"Tinzaparin"	DB06822	small molecule
ITGA4	"Vedolizumab"	DB09033	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."