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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: INO80D

Summary for INO80D

Gene information	Gene symbol	INO80D
	Ensembl ID	ENSG00000283510
	Entrez ID	54891
	Gene name	INO80 complex subunit D
	Synonyms	FLJ20309
	Gene type	protein_coding
	UniProtAcc	Q53TQ3

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Dataset with differentially expressed gene: INO80D

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.286199	4.60e-37
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.265601	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.287613	1.13e-34

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Expression of INO80D in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to INO80D

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating INO80D

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
INO80D	hsa-miR-5011-5p	99.9999	NM_017759
INO80D	hsa-miR-190a-3p	99.9985	NM_017759
INO80D	hsa-miR-5692a	99.9413	NM_017759
INO80D	hsa-miR-607	99.79	NM_017759
INO80D	hsa-miR-5688	99.7341	NM_017759
INO80D	hsa-miR-4789-5p	99.6542	NM_017759
INO80D	hsa-miR-495-3p	99.6482	NM_017759
INO80D	hsa-miR-12124	99.4329	NM_017759
INO80D	hsa-miR-5582-3p	99.2969	NM_017759
INO80D	hsa-miR-1185-1-3p	99.1406	NM_017759
INO80D	hsa-miR-1185-2-3p	99.1406	NM_017759
INO80D	hsa-let-7f-2-3p	98.9936	NM_017759
INO80D	hsa-miR-3662	98.9197	NM_017759
INO80D	hsa-miR-520d-5p	98.8763	NM_017759
INO80D	hsa-miR-524-5p	98.8763	NM_017759
INO80D	hsa-miR-548g-3p	98.8666	NM_017759
INO80D	hsa-miR-4789-3p	98.8157	NM_017759
INO80D	hsa-miR-577	98.7352	NM_017759
INO80D	hsa-miR-3613-3p	98.6699	NM_017759
INO80D	hsa-miR-548ar-3p	98.6318	NM_017759
INO80D	hsa-miR-101-3p	98.5905	NM_017759
INO80D	hsa-miR-651-3p	98.4744	NM_017759
INO80D	hsa-miR-548c-3p	98.271	NM_017759
INO80D	hsa-miR-4495	98.2473	NM_017759
INO80D	hsa-miR-548e-3p	98.1583	NM_017759
INO80D	hsa-miR-548bc	98.1583	NM_017759
INO80D	hsa-miR-548a-3p	98.1583	NM_017759
INO80D	hsa-miR-548az-3p	98.1583	NM_017759
INO80D	hsa-miR-548f-3p	98.1583	NM_017759
INO80D	hsa-miR-1208	98.1568	NM_017759
INO80D	hsa-let-7f-1-3p	98.1547	NM_017759
INO80D	hsa-miR-98-3p	98.1547	NM_017759
INO80D	hsa-let-7b-3p	98.1547	NM_017759
INO80D	hsa-let-7a-3p	98.1547	NM_017759
INO80D	hsa-miR-4496	98.0669	NM_017759
INO80D	hsa-miR-5197-3p	98.0664	NM_017759
INO80D	hsa-miR-466	98.0514	NM_017759
INO80D	hsa-miR-4262	98.0319	NM_017759
INO80D	hsa-miR-3148	97.9583	NM_017759
INO80D	hsa-miR-10526-3p	97.8561	NM_017759
INO80D	hsa-miR-4643	97.7902	NM_017759
INO80D	hsa-miR-5683	97.7265	NM_017759
INO80D	hsa-miR-7856-5p	97.7136	NM_017759
INO80D	hsa-miR-1277-5p	97.6726	NM_017759
INO80D	hsa-miR-1184	97.6135	NM_017759
INO80D	hsa-miR-3916	97.5895	NM_017759
INO80D	hsa-miR-3125	97.5895	NM_017759
INO80D	hsa-miR-548x-3p	97.2968	NM_017759
INO80D	hsa-miR-548aj-3p	97.2968	NM_017759
INO80D	hsa-miR-181c-5p	97.2508	NM_017759

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Motifs and transcription factors (TFs) regulating INO80D

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
INO80D	hdpi__ZNF304	ZNF304 (directAnnotation).
INO80D	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
INO80D	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
INO80D	hocomoco__ZFX_MOUSE.H11MO.1.B	ZFY (inferredBy_Orthology).
INO80D	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
INO80D	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
INO80D	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
INO80D	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
INO80D	tfdimers__MD00038	TFAP2C (directAnnotation).
INO80D	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
INO80D	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."