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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: IGFBP7

Summary for IGFBP7

Gene information	Gene symbol	IGFBP7
	Ensembl ID	ENSG00000163453
	Entrez ID	3490
	Gene name	insulin like growth factor binding protein 7
	Synonyms	FSTL2\|IGFBP-7\|MAC25\|PSF
	Gene type	protein_coding
	UniProtAcc	Q16270

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Dataset with differentially expressed gene: IGFBP7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	-0.256127	9.18e-31
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.805426	2.23e-05
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	NK cells	-0.48504	8.84e-09
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.433136	1.16e-34
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	-0.278228	5.29e-20
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Malignant cells	0.588454	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Erythrocytes	0.666002	1.06e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.646672	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	1.1448	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	0.821106	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	-0.936968	1.13e-23
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.482607	1.74e-06
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.99466	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	NK cells	0.323051	7.19e-06

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Expression of IGFBP7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IGFBP7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IGFBP7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IGFBP7	hsa-miR-3686	95.8508	NM_001553
IGFBP7	hsa-miR-4718	93.604	NM_001253835
IGFBP7	hsa-miR-3674	92.5247	NM_001553
IGFBP7	hsa-miR-4771	90.2431	NM_001553
IGFBP7	hsa-miR-3182	90.0274	NM_001553
IGFBP7	hsa-miR-12136	89.0898	NM_001553
IGFBP7	hsa-miR-26b-3p	86.6786	NM_001253835
IGFBP7	hsa-miR-5004-3p	83.8333	NM_001553
IGFBP7	hsa-miR-1277-5p	81.5665	NM_001553
IGFBP7	hsa-miR-3935	81.4246	NM_001553
IGFBP7	hsa-miR-548t-3p	80.7525	NM_001553
IGFBP7	hsa-miR-548aa	80.7525	NM_001553
IGFBP7	hsa-miR-548ap-3p	80.7525	NM_001553
IGFBP7	hsa-miR-365a-3p	80.4542	NM_001253835
IGFBP7	hsa-miR-365b-3p	80.4542	NM_001253835
IGFBP7	hsa-miR-153-5p	80.2928	NM_001253835

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Motifs and transcription factors (TFs) regulating IGFBP7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IGFBP7	tfdimers__MD00593	GABPA; PITX3 (directAnnotation).
IGFBP7	transfac_pro__M05423	RREB1 (directAnnotation).
IGFBP7	metacluster_33.3	ZNF134; ZNF174 (directAnnotation).
IGFBP7	taipale_tf_pairs__TEAD4_ELF1_RGAATGCGGAAGTR_CAP	ELF1; TEAD4 (directAnnotation).
IGFBP7	tfdimers__MD00419	BHLHE41; YY2 (directAnnotation).
IGFBP7	kznf__ZNF749_Imbeault2017_RP_RCADE	ZNF749 (directAnnotation).
IGFBP7	kznf__ZKSCAN2_Imbeault2017_OM_RCADE	ZKSCAN2 (directAnnotation).
IGFBP7	transfac_pro__M07061	POU4F3 (directAnnotation).
IGFBP7	kznf__CTCF_Transfac.4_Transfac	CTCF (directAnnotation).
IGFBP7	swissregulon__mm__Nr4a2	NR4A2 (inferredBy_Orthology).
IGFBP7	tfdimers__MD00101	HOXA13; IKZF1 (directAnnotation).
IGFBP7	metacluster_9.13	LHX8 (directAnnotation).
IGFBP7	metacluster_82.4	ZFP30 (directAnnotation).
IGFBP7	cisbp__M00262	ARX (directAnnotation).
IGFBP7	transfac_pro__M06438	ZNF227 (directAnnotation).
IGFBP7	transfac_pro__M05870	ZNF625 (directAnnotation).
IGFBP7	transfac_pro__M05769	ZNF48 (inferredBy_Orthology).
IGFBP7	transfac_pro__M06007	ZNF69 (directAnnotation).
IGFBP7	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
IGFBP7	transfac_pro__M06863	ZNF789 (directAnnotation).
IGFBP7	metacluster_152.2	TWIST1 (directAnnotation).
IGFBP7	transfac_pro__M01665	IRF8 (directAnnotation).
IGFBP7	transfac_pro__M05836	ZNF572 (directAnnotation).
IGFBP7	jaspar__MA1105.2	GRHL2 (directAnnotation).
IGFBP7	metacluster_130.16	ZNF705A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
IGFBP7	"Insulin human"	DB00030	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."