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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HNRNPA3

Summary for HNRNPA3

Gene information	Gene symbol	HNRNPA3
	Ensembl ID	ENSG00000170144
	Entrez ID	220988
	Gene name	heterogeneous nuclear ribonucleoprotein A3
	Synonyms	HNRPA3
	Gene type	protein_coding
	UniProtAcc	P51991

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Dataset with differentially expressed gene: HNRNPA3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.411414	1.49e-41
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.56306	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.284032	1.09e-38
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.354529	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.282212	1.44e-40
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.420361	3.26e-26
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	cDCs	-0.309136	3.63e-02
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.304883	4.64e-08
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.264482	2.49e-11
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.563676	4.86e-27
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.744621	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.287044	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.366221	6.80e-30
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.518627	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.260837	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.979445	1.26e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.465456	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.333407	2.59e-28
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.469359	4.61e-35
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.332493	1.63e-20
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.490758	4.56e-40

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Expression of HNRNPA3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HNRNPA3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HNRNPA3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HNRNPA3	hsa-miR-3611	93.8447	NM_194247
HNRNPA3	hsa-miR-450a-1-3p	93.1564	NM_194247
HNRNPA3	hsa-miR-485-3p	90.4501	NM_194247
HNRNPA3	hsa-miR-539-3p	90.4501	NM_194247
HNRNPA3	hsa-miR-8070	89.9677	NM_194247
HNRNPA3	hsa-miR-4719	89.167	NM_194247
HNRNPA3	hsa-miR-938	89.0417	NM_194247
HNRNPA3	hsa-miR-7-1-3p	88.1284	NM_194247
HNRNPA3	hsa-miR-7152-5p	87.5023	NM_194247
HNRNPA3	hsa-miR-155-5p	86.9969	NM_194247
HNRNPA3	hsa-miR-7-2-3p	85.4895	NM_194247
HNRNPA3	hsa-miR-548aa	83.819	NM_194247
HNRNPA3	hsa-miR-548ap-3p	83.819	NM_194247
HNRNPA3	hsa-miR-548t-3p	83.819	NM_194247
HNRNPA3	hsa-miR-3175	83.1837	NM_194247
HNRNPA3	hsa-miR-670-5p	81.9273	NM_194247

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Motifs and transcription factors (TFs) regulating HNRNPA3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HNRNPA3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
HNRNPA3	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
HNRNPA3	transfac_pro__M05432	ZSCAN18 (directAnnotation).
HNRNPA3	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
HNRNPA3	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
HNRNPA3	metacluster_182.10	ZFX (directAnnotation).
HNRNPA3	transfac_pro__M02913	SP140 (inferredBy_Orthology).
HNRNPA3	metacluster_141.2	E2F2; E2F3 (directAnnotation).
HNRNPA3	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
HNRNPA3	transfac_pro__M00492	STAT1 (directAnnotation).
HNRNPA3	metacluster_151.2	ZNF23 (directAnnotation).
HNRNPA3	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
HNRNPA3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
HNRNPA3	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
HNRNPA3	transfac_pro__M01253	CNOT3 (directAnnotation).
HNRNPA3	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
HNRNPA3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
HNRNPA3	transfac_pro__M01199	TRIM28 (directAnnotation).
HNRNPA3	cisbp__M00968	MTF2 (directAnnotation).
HNRNPA3	transfac_pro__M12697	ZNF142 (directAnnotation).
HNRNPA3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
HNRNPA3	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
HNRNPA3	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
HNRNPA3	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
HNRNPA3	metacluster_81.7	CREB1 (directAnnotation).
HNRNPA3	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
HNRNPA3	transfac_pro__M06711	ZNF160 (directAnnotation).
HNRNPA3	taipale_tf_pairs__ALX4_EOMES_NGYGYTAAYNNNNNNTNACACNN_CAP	ALX4; EOMES (directAnnotation).
HNRNPA3	taipale_tf_pairs__TEAD4_CEBPD_RGWATGYNNTTRCGYAAN_CAP	CEBPD; TEAD4 (directAnnotation).
HNRNPA3	transfac_pro__M07362	NANOG (directAnnotation). NANOGP8 (inferredBy_Orthology).
HNRNPA3	transfac_pro__M04923	ZBTB33 (directAnnotation).
HNRNPA3	transfac_pro__M07327	NANOG (directAnnotation). NANOGP8 (inferredBy_Orthology).
HNRNPA3	transfac_pro__M06847	SALL3 (inferredBy_Orthology).
HNRNPA3	transfac_pro__M06037	ZNF197 (directAnnotation).
HNRNPA3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
HNRNPA3	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
HNRNPA3	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
HNRNPA3	transfac_pro__M07310	SP5 (directAnnotation).
HNRNPA3	hdpi__HIP2	UBE2K (directAnnotation).
HNRNPA3	hdpi__ZNF304	ZNF304 (directAnnotation).
HNRNPA3	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
HNRNPA3	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
HNRNPA3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
HNRNPA3	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
HNRNPA3	cisbp__M00788	ZFY (inferredBy_Orthology).
HNRNPA3	transfac_pro__M00430	E2F1 (directAnnotation).
HNRNPA3	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
HNRNPA3	transfac_pro__M00938	E2F1 (directAnnotation).
HNRNPA3	transfac_pro__M07436	WT1 (directAnnotation).
HNRNPA3	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."