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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: HMGA1

Summary for HMGA1

Gene information	Gene symbol	HMGA1
	Ensembl ID	ENSG00000137309
	Entrez ID	3159
	Gene name	high mobility group AT-hook 1
	Synonyms	HMGIY
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HMGA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.549349	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.330989	2.21e-29
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.687907	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.280809	4.33e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.252288	4.73e-03
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.444163	7.12e-11
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	-0.486748	2.99e-09
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.418684	3.01e-20
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.404781	3.25e-06
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.331656	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.402037	8.56e-26
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.305155	6.15e-10
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	1.9053	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.338257	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	-1.10277	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.440223	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.639341	2.08e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.254689	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.342555	9.84e-05
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.407068	1.40e-45
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.557708	1.40e-45
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.764924	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-1.01477	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Erythrocytes	-0.495976	7.33e-03
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.50284	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.642634	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-1.56288	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-2.40779	0.00e+00

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Expression of HMGA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HMGA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
HMGA1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating HMGA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HMGA1	hsa-miR-296-5p	96.0892	NM_001319079
HMGA1	hsa-miR-6887-3p	92.6009	NM_001319077
HMGA1	hsa-miR-4505	91.1592	NM_001319077
HMGA1	hsa-miR-5787	91.1592	NM_001319077
HMGA1	hsa-miR-4286	90.6484	NM_001319077
HMGA1	hsa-miR-6870-5p	90.5567	NM_001319079
HMGA1	hsa-miR-6847-5p	89.3256	NM_001319079
HMGA1	hsa-miR-3611	88.3564	NM_001319077
HMGA1	hsa-miR-7111-5p	88.2385	NM_001319079
HMGA1	hsa-miR-4723-5p	88.2385	NM_001319079
HMGA1	hsa-miR-5698	88.2385	NM_001319079
HMGA1	hsa-miR-1297	87.7228	NM_001319079
HMGA1	hsa-miR-195-5p	87.6957	NM_001319079
HMGA1	hsa-miR-15a-5p	87.6957	NM_001319079
HMGA1	hsa-miR-16-5p	87.6957	NM_001319079
HMGA1	hsa-miR-15b-5p	87.6957	NM_001319079
HMGA1	hsa-miR-198	87.0699	NM_001319077
HMGA1	hsa-miR-6721-5p	86.1515	NM_001319077
HMGA1	hsa-miR-1275	85.8432	NM_001319079
HMGA1	hsa-miR-26a-5p	85.6307	NM_001319079
HMGA1	hsa-miR-26b-5p	85.6307	NM_001319079
HMGA1	hsa-miR-6838-5p	84.5337	NM_001319079
HMGA1	hsa-miR-6081	83.9768	NM_001319079
HMGA1	hsa-miR-4465	83.5206	NM_001319079
HMGA1	hsa-miR-497-5p	83.4325	NM_001319079
HMGA1	hsa-miR-424-5p	83.4325	NM_001319079
HMGA1	hsa-miR-4500	81.3745	NM_001319079
HMGA1	hsa-miR-5591-5p	80.3163	NM_001319079
HMGA1	hsa-miR-4300	80.3163	NM_001319079
HMGA1	hsa-miR-5196-5p	80.3126	NM_001319079
HMGA1	hsa-miR-6825-5p	80.244	NM_001319079

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Motifs and transcription factors (TFs) regulating HMGA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HMGA1	dbtfbs__ZFP91_K562_ENCSR898XMH_merged_N1	ZFP91 (directAnnotation).
HMGA1	metacluster_31.4	ZFP3 (directAnnotation). ZFP3 (inferredBy_Orthology).
HMGA1	transfac_pro__M07375	BCL6 (directAnnotation).
HMGA1	kznf__ZNF614_Imbeault2017_RP_ChIP-seq	ZNF614 (directAnnotation).
HMGA1	tfdimers__MD00123	E2F1; SOX17 (directAnnotation).
HMGA1	transfac_pro__M04887	TCF12 (directAnnotation).
HMGA1	transfac_pro__M12358	MLX (inferredBy_Orthology).
HMGA1	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
HMGA1	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
HMGA1	metacluster_22.34	BACH2 (directAnnotation).
HMGA1	metacluster_22.20	MAFG (directAnnotation).
HMGA1	metacluster_22.35	MAFK (directAnnotation).
HMGA1	metacluster_22.16	BACH2 (directAnnotation).
HMGA1	metacluster_22.11	NFE2 (directAnnotation).
HMGA1	cisbp__M01815	CEBPE (inferredBy_Orthology).
HMGA1	metacluster_22.33	MAFK (inferredBy_Orthology).
HMGA1	jaspar__MA1125.1	ZNF384 (directAnnotation).
HMGA1	metacluster_32.24	ZNF287 (directAnnotation).
HMGA1	metacluster_22.39	NFE2L2 (directAnnotation).
HMGA1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
HMGA1	transfac_pro__M04916	TAF1 (directAnnotation).
HMGA1	metacluster_22.17	NFE2 (directAnnotation).
HMGA1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
HMGA1	metacluster_175.6	GRHL1; GRHL1; GRHL1; GRHL1; TFCP2 (directAnnotation).
HMGA1	tfdimers__MD00157	MYB; TLX2 (directAnnotation).
HMGA1	tfdimers__MD00546	HOXC8; NFE2L1 (directAnnotation).
HMGA1	tfdimers__MD00126	NKX6-2 (directAnnotation).
HMGA1	swissregulon__hs__FUBP1	FUBP1 (directAnnotation).
HMGA1	tfdimers__MD00416	HNF1A; HNF1B (directAnnotation).
HMGA1	taipale_tf_pairs__FOXJ2_ELF1_RMAGAAAACCGAANN_CAP_repr	ELF1; FOXJ2 (directAnnotation).
HMGA1	kznf__ZSCAN29_TF_Evolution_PBM	ZSCAN29 (directAnnotation).
HMGA1	tfdimers__MD00128	CDX2; PDX1 (directAnnotation).
HMGA1	transfac_pro__M06032	ZNF727 (directAnnotation).
HMGA1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
HMGA1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
HMGA1	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
HMGA1	metacluster_161.2	LHX8 (directAnnotation).
HMGA1	transfac_pro__M06173	ZNF85 (directAnnotation).
HMGA1	transfac_pro__M00655	ETV4 (directAnnotation).
HMGA1	homer__ACAGGATGTGGT_ETS_RUNX	RUNX1 (directAnnotation).
HMGA1	cisbp__M00249	WT1 (directAnnotation).
HMGA1	transfac_pro__M01122	ZNF219 (directAnnotation).
HMGA1	metacluster_151.2	ZNF23 (directAnnotation).
HMGA1	metacluster_7.13	ZFX (directAnnotation).
HMGA1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
HMGA1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
HMGA1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
HMGA1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
HMGA1	transfac_pro__M01253	CNOT3 (directAnnotation).
HMGA1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
HMGA1	tfdimers__MD00339	down	Malignant cells	GSE131984_JQ1	NA
HMGA1	tfdimers__MD00088	down	Erythrocytes	GSE161801_IMiD	pre
HMGA1	tfdimers__MD00410	down	Erythrocytes	GSE189460	pre
HMGA1	tfdimers__MD00410	down	CD8+ T cells	GSE199333	pre

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."