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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HEBP2

Summary for HEBP2

Gene information	Gene symbol	HEBP2
	Ensembl ID	ENSG00000051620
	Entrez ID	23593
	Gene name	heme binding protein 2
	Synonyms	C6orf34\|SOUL
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HEBP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.10357	4.93e-09
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.339626	3.94e-19
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.399555	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.312132	9.70e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.314057	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.457707	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.385441	2.94e-03
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.32178	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.329892	5.84e-06
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.331267	1.98e-26
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.262729	1.47e-42
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-1.00965	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.326023	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.494735	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	-0.359318	6.75e-06
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.387514	2.81e-23
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.388996	5.45e-35
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.389059	0.00e+00

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Expression of HEBP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HEBP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HEBP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HEBP2	hsa-miR-1249-5p	93.9488	NM_014320
HEBP2	hsa-miR-6797-5p	93.9488	NM_014320
HEBP2	hsa-miR-302c-5p	93.2693	NM_014320
HEBP2	hsa-miR-3143	92.1003	NM_014320
HEBP2	hsa-miR-29c-5p	87.3604	NM_014320
HEBP2	hsa-miR-506-3p	86.7019	NM_014320
HEBP2	hsa-miR-124-3p	86.7019	NM_014320
HEBP2	hsa-miR-577	81.4217	NM_014320

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Motifs and transcription factors (TFs) regulating HEBP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HEBP2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
HEBP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
HEBP2	transfac_pro__M07310	SP5 (directAnnotation).
HEBP2	transfac_pro__M12586	MYBL2 (directAnnotation).
HEBP2	metacluster_26.5	FOXM1; MYBL2 (directAnnotation).
HEBP2	metacluster_178.16	ZNF660; ZNF660 (directAnnotation).
HEBP2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
HEBP2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
HEBP2	transfac_pro__M01122	ZNF219 (directAnnotation).
HEBP2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
HEBP2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
HEBP2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
HEBP2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
HEBP2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
HEBP2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
HEBP2	transfac_pro__M01253	CNOT3 (directAnnotation).
HEBP2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
HEBP2	metacluster_3.10	KLF2; KLF4 (directAnnotation).
HEBP2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
HEBP2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
HEBP2	tfdimers__MD00151	CHURC1 (directAnnotation).
HEBP2	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
HEBP2	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
HEBP2	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
HEBP2	transfac_pro__M12697	ZNF142 (directAnnotation).
HEBP2	transfac_pro__M01303	SP1 (directAnnotation).
HEBP2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
HEBP2	transfac_public__M00491	PATZ1 (directAnnotation).
HEBP2	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
HEBP2	transfac_pro__M07397	ZNF148 (directAnnotation).
HEBP2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
HEBP2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
HEBP2	jaspar__MA1708.1	ETV7 (directAnnotation).
HEBP2	hdpi__TP73	TP73 (directAnnotation).
HEBP2	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
HEBP2	metacluster_14.20	TFEB (directAnnotation).
HEBP2	cisbp__M01725	SREBF2 (inferredBy_Orthology).
HEBP2	metacluster_57.2	BACH1; MITF; MITF; TFE3; TFE3; TFE3; TFEB; USF2 (directAnnotation). MITF; TFE3; USF1; USF2 (inferredBy_Orthology).
HEBP2	transfac_pro__M06601	ZNF501 (directAnnotation).
HEBP2	metacluster_14.23	TFE3 (directAnnotation).
HEBP2	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
HEBP2	transfac_pro__M02089	E2F3 (directAnnotation).
HEBP2	transfac_pro__M04817	ZBTB33 (directAnnotation).
HEBP2	tfdimers__MD00483	ZBTB14 (directAnnotation).
HEBP2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
HEBP2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
HEBP2	transfac_pro__M06800	ZBTB22 (inferredBy_Orthology).
HEBP2	metacluster_130.9	ZNF569 (directAnnotation). ZNF569 (inferredBy_Orthology).
HEBP2	transfac_pro__M06292	ZNF766 (directAnnotation).
HEBP2	transfac_pro__M06181	ZNF165 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."