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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GOLIM4

Summary for GOLIM4

Gene information	Gene symbol	GOLIM4
	Ensembl ID	ENSG00000173905
	Entrez ID	27333
	Gene name	golgi integral membrane protein 4
	Synonyms	GIMPC\|GOLPH4\|GPP130\|P138
	Gene type	protein_coding
	UniProtAcc	O00461

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Dataset with differentially expressed gene: GOLIM4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.41701	1.51e-28
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.375931	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.616482	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.569982	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.626839	0.00e+00

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Expression of GOLIM4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GOLIM4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GOLIM4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GOLIM4	hsa-miR-6074	98.6805	NM_014498
GOLIM4	hsa-miR-576-5p	98.2934	NM_001308155
GOLIM4	hsa-miR-3671	94.044	NM_014498
GOLIM4	hsa-miR-6508-5p	92.9571	NM_014498
GOLIM4	hsa-miR-485-3p	92.8073	NM_014498
GOLIM4	hsa-miR-539-3p	92.8073	NM_014498
GOLIM4	hsa-let-7f-1-3p	91.3915	NM_001308155
GOLIM4	hsa-miR-98-3p	91.3915	NM_001308155
GOLIM4	hsa-let-7b-3p	91.3915	NM_001308155
GOLIM4	hsa-let-7a-3p	91.3915	NM_001308155
GOLIM4	hsa-miR-4762-3p	91.1906	NM_014498
GOLIM4	hsa-miR-4263	90.859	NM_001308155
GOLIM4	hsa-miR-8067	90.692	NM_014498
GOLIM4	hsa-miR-222-5p	90.5812	NM_001308155
GOLIM4	hsa-miR-323a-3p	90.3648	NM_014498
GOLIM4	hsa-miR-1277-5p	90.0011	NM_001308155
GOLIM4	hsa-miR-374c-5p	89.5086	NM_001308155
GOLIM4	hsa-miR-655-3p	89.5086	NM_001308155
GOLIM4	hsa-miR-12123	88.0295	NM_014498
GOLIM4	hsa-miR-646	87.5791	NM_001308155
GOLIM4	hsa-miR-4427	87.5723	NM_014498
GOLIM4	hsa-miR-8063	87.5446	NM_001308155
GOLIM4	hsa-miR-1185-1-3p	87.229	NM_001308155
GOLIM4	hsa-let-7f-2-3p	87.229	NM_001308155
GOLIM4	hsa-miR-4789-5p	87.229	NM_001308155
GOLIM4	hsa-miR-1185-2-3p	87.229	NM_001308155
GOLIM4	hsa-miR-6516-5p	86.8527	NM_014498
GOLIM4	hsa-miR-4753-3p	86.6378	NM_014498
GOLIM4	hsa-miR-4659a-3p	86.5343	NM_014498
GOLIM4	hsa-miR-4659b-3p	86.5343	NM_014498
GOLIM4	hsa-miR-4775	85.493	NM_014498
GOLIM4	hsa-miR-3920	85.3039	NM_014498
GOLIM4	hsa-miR-153-5p	84.8255	NM_014498
GOLIM4	hsa-miR-218-2-3p	84.3841	NM_014498
GOLIM4	hsa-miR-520g-3p	84.2349	NM_014498
GOLIM4	hsa-miR-520h	84.2349	NM_014498
GOLIM4	hsa-miR-4506	83.8326	NM_014498
GOLIM4	hsa-let-7c-3p	83.7406	NM_001308155
GOLIM4	hsa-miR-4698	83.4141	NM_001308155
GOLIM4	hsa-miR-5692a	83.2253	NM_001308155
GOLIM4	hsa-miR-561-3p	82.7966	NM_001308155
GOLIM4	hsa-miR-4477b	82.0285	NM_014498
GOLIM4	hsa-miR-10395-3p	81.9667	NM_014498
GOLIM4	hsa-miR-3646	81.9283	NM_001308155
GOLIM4	hsa-miR-497-3p	81.3163	NM_001308155
GOLIM4	hsa-miR-630	81.3123	NM_014498
GOLIM4	hsa-miR-876-5p	81.1104	NM_014498
GOLIM4	hsa-miR-3167	80.6769	NM_014498
GOLIM4	hsa-miR-4663	80.5802	NM_001308155
GOLIM4	hsa-miR-548t-3p	80.4806	NM_001308155

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Motifs and transcription factors (TFs) regulating GOLIM4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GOLIM4	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
GOLIM4	transfac_pro__M07436	WT1 (directAnnotation).
GOLIM4	transfac_pro__M02281	SP1 (directAnnotation).
GOLIM4	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
GOLIM4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
GOLIM4	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
GOLIM4	transfac_pro__M02898	SMAD3 (directAnnotation).
GOLIM4	transfac_public__M00491	PATZ1 (directAnnotation).
GOLIM4	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
GOLIM4	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
GOLIM4	metacluster_135.11	NR2C2 (directAnnotation).
GOLIM4	tfdimers__MD00038	TFAP2C (directAnnotation).
GOLIM4	cisbp__M00968	MTF2 (directAnnotation).
GOLIM4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
GOLIM4	cisbp__M00341	PAX6 (directAnnotation).
GOLIM4	metacluster_198.3	ZFP64 (directAnnotation).
GOLIM4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GOLIM4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
GOLIM4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
GOLIM4	cisbp__M00788	ZFY (inferredBy_Orthology).
GOLIM4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
GOLIM4	metacluster_175.1	ZNF283 (directAnnotation).
GOLIM4	hdpi__ZNF304	ZNF304 (directAnnotation).
GOLIM4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
GOLIM4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
GOLIM4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GOLIM4	transfac_pro__M01199	TRIM28 (directAnnotation).
GOLIM4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
GOLIM4	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
GOLIM4	transfac_pro__M03806	ZBTB7C (directAnnotation).
GOLIM4	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
GOLIM4	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
GOLIM4	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
GOLIM4	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
GOLIM4	hdpi__TP73	TP73 (directAnnotation).
GOLIM4	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
GOLIM4	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
GOLIM4	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
GOLIM4	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
GOLIM4	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
GOLIM4	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
GOLIM4	transfac_pro__M01298	MECP2 (directAnnotation).
GOLIM4	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
GOLIM4	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
GOLIM4	transfac_pro__M00492	STAT1 (directAnnotation).
GOLIM4	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
GOLIM4	transfac_pro__M05981	ZNF233 (directAnnotation).
GOLIM4	jaspar__MA0502.2	NFYB (directAnnotation).
GOLIM4	transfac_pro__M04950	EGR1 (directAnnotation).
GOLIM4	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."