Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FXR1

Summary for FXR1

Gene information	Gene symbol	FXR1
	Ensembl ID	ENSG00000114416
	Entrez ID	8087
	Gene name	FMR1 autosomal homolog 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: FXR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.296762	4.60e-18
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.501912	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.251256	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.415404	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.412561	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.683952	4.19e-04
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.435726	4.67e-21

Top

Expression of FXR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to FXR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating FXR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FXR1	hsa-miR-4659b-3p	99.54	NM_001013438
FXR1	hsa-miR-4659a-3p	99.54	NM_001013438
FXR1	hsa-miR-152-3p	98.1895	NM_001013438
FXR1	hsa-miR-148b-3p	98.1895	NM_001013438
FXR1	hsa-miR-148a-3p	98.1895	NM_001013438
FXR1	hsa-miR-627-3p	97.6396	NM_001013438
FXR1	hsa-miR-4502	97.3814	NM_005087
FXR1	hsa-miR-302c-5p	97.3517	NM_005087
FXR1	hsa-miR-7856-5p	97.1587	NM_001013438
FXR1	hsa-miR-7844-5p	97.1357	NM_005087
FXR1	hsa-miR-6875-3p	96.4469	NM_001013438
FXR1	hsa-miR-3973	96.1845	NM_001013438
FXR1	hsa-miR-448	93.7132	NM_001013438
FXR1	hsa-miR-4778-3p	93.1383	NM_001013438
FXR1	hsa-miR-3133	93.1255	NM_005087
FXR1	hsa-miR-4495	92.5497	NM_005087
FXR1	hsa-miR-103a-2-5p	92.5124	NM_001013438
FXR1	hsa-miR-103a-1-5p	92.5124	NM_001013438
FXR1	hsa-miR-4773	92.3107	NM_001013438
FXR1	hsa-miR-455-3p	92.0668	NM_005087
FXR1	hsa-miR-122b-5p	91.8982	NM_001013438
FXR1	hsa-miR-4310	91.5687	NM_001013438
FXR1	hsa-miR-1468-3p	90.9205	NM_005087
FXR1	hsa-miR-7157-5p	90.5572	NM_001013438
FXR1	hsa-miR-4527	89.8341	NM_001013438
FXR1	hsa-miR-3180-5p	89.6107	NM_001013438
FXR1	hsa-miR-30a-3p	89.5275	NM_001013438
FXR1	hsa-miR-30d-3p	89.5275	NM_001013438
FXR1	hsa-miR-30e-3p	89.5275	NM_001013438
FXR1	hsa-miR-6890-3p	89.5193	NM_001013438
FXR1	hsa-miR-6778-5p	89.4051	NM_005087
FXR1	hsa-miR-1233-5p	89.4051	NM_005087
FXR1	hsa-miR-7-2-3p	89.3805	NM_005087
FXR1	hsa-miR-199a-3p	89.2995	NM_001013438
FXR1	hsa-miR-3129-5p	89.2995	NM_001013438
FXR1	hsa-miR-199b-3p	89.2995	NM_001013438
FXR1	hsa-miR-520f-5p	89.1757	NM_005087
FXR1	hsa-miR-122b-3p	89.1339	NM_001013438
FXR1	hsa-miR-21-3p	89.1339	NM_001013438
FXR1	hsa-miR-4694-3p	88.8301	NM_005087
FXR1	hsa-miR-4328	88.632	NM_001013438
FXR1	hsa-miR-552-5p	88.6057	NM_005087
FXR1	hsa-miR-607	88.49	NM_005087
FXR1	hsa-miR-222-5p	87.6665	NM_001013438
FXR1	hsa-miR-7-1-3p	87.4792	NM_005087
FXR1	hsa-miR-3158-5p	87.2997	NM_001013438
FXR1	hsa-miR-6503-5p	86.9023	NM_001013438
FXR1	hsa-miR-92b-3p	86.7365	NM_001013438
FXR1	hsa-miR-92a-3p	86.7365	NM_001013438
FXR1	hsa-miR-32-5p	86.7365	NM_001013438

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating FXR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FXR1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
FXR1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
FXR1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
FXR1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
FXR1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
FXR1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
FXR1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
FXR1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
FXR1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
FXR1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
FXR1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
FXR1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
FXR1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
FXR1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
FXR1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
FXR1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
FXR1	transfac_pro__M07310	SP5 (directAnnotation).
FXR1	transfac_pro__M00938	E2F1 (directAnnotation).
FXR1	transfac_pro__M04893	TAF1 (directAnnotation).
FXR1	transfac_pro__M04817	ZBTB33 (directAnnotation).
FXR1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
FXR1	transfac_pro__M12697	ZNF142 (directAnnotation).
FXR1	tfdimers__MD00364	WT1 (directAnnotation).
FXR1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
FXR1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
FXR1	transfac_pro__M01973	PLAG1 (directAnnotation).
FXR1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
FXR1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
FXR1	metacluster_143.13	ZBTB7A (directAnnotation).
FXR1	transfac_pro__M07387	ZBTB7A (directAnnotation).
FXR1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
FXR1	metacluster_144.13	HIC1; HIC1 (directAnnotation).
FXR1	transfac_pro__M00665	SP3 (directAnnotation).
FXR1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
FXR1	transfac_pro__M02898	SMAD3 (directAnnotation).
FXR1	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
FXR1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
FXR1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
FXR1	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
FXR1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
FXR1	transfac_pro__M07329	SP7 (directAnnotation).
FXR1	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
FXR1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
FXR1	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
FXR1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
FXR1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
FXR1	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
FXR1	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
FXR1	transfac_pro__M06249	ZNF616 (directAnnotation).
FXR1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).

Page: 1 2 3

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."