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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FUNDC2

Summary for FUNDC2

Gene information	Gene symbol	FUNDC2
	Ensembl ID	ENSG00000165775
	Entrez ID	65991
	Gene name	FUN14 domain containing 2
	Synonyms	DC44\|HCBP6
	Gene type	protein_coding
	UniProtAcc	Q9BWH2

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Dataset with differentially expressed gene: FUNDC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.408236	2.87e-02
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.58909	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.453615	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.757766	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.379181	8.91e-35
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.678328	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.298528	7.36e-08
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.338369	5.24e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.299574	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.523902	1.27e-36

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Expression of FUNDC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FUNDC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FUNDC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FUNDC2	hsa-miR-548p	96.5506	NM_023934
FUNDC2	hsa-miR-6867-5p	94.5583	NM_023934
FUNDC2	hsa-miR-3686	93.6121	NM_023934
FUNDC2	hsa-miR-548aa	92.217	NM_023934
FUNDC2	hsa-miR-548t-3p	92.217	NM_023934
FUNDC2	hsa-miR-548ap-3p	92.217	NM_023934
FUNDC2	hsa-miR-4637	90.7794	NM_023934
FUNDC2	hsa-miR-122-5p	90.5169	NM_023934
FUNDC2	hsa-miR-1283	89.2074	NM_023934
FUNDC2	hsa-miR-548an	88.013	NM_023934
FUNDC2	hsa-miR-4534	86.4281	NM_023934
FUNDC2	hsa-miR-8082	86.2075	NM_023934
FUNDC2	hsa-miR-3915	86.0865	NM_023934
FUNDC2	hsa-miR-654-3p	83.3476	NM_023934
FUNDC2	hsa-miR-5011-5p	82.6898	NM_023934
FUNDC2	hsa-miR-548ah-5p	82.5135	NM_023934
FUNDC2	hsa-miR-3609	82.5135	NM_023934
FUNDC2	hsa-miR-2052	81.3817	NM_023934
FUNDC2	hsa-miR-1207-5p	81.0086	NM_023934
FUNDC2	hsa-miR-584-3p	80.4079	NM_023934
FUNDC2	hsa-miR-582-3p	80.2754	NM_023934

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Motifs and transcription factors (TFs) regulating FUNDC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FUNDC2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
FUNDC2	metacluster_151.2	ZNF23 (directAnnotation).
FUNDC2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FUNDC2	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
FUNDC2	hdpi__ELF2	ELF2 (directAnnotation).
FUNDC2	swissregulon__hs__ELK1	ELK1 (directAnnotation).
FUNDC2	metacluster_81.7	CREB1 (directAnnotation).
FUNDC2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
FUNDC2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
FUNDC2	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
FUNDC2	cisbp__M07938	E2F1 (directAnnotation).
FUNDC2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
FUNDC2	transfac_pro__M04817	ZBTB33 (directAnnotation).
FUNDC2	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
FUNDC2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
FUNDC2	metacluster_163.2	ZNF682 (directAnnotation).
FUNDC2	transfac_pro__M00938	E2F1 (directAnnotation).
FUNDC2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FUNDC2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
FUNDC2	transfac_pro__M01303	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."