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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: FN1

Summary for FN1

Gene information	Gene symbol	FN1
	Ensembl ID	ENSG00000115414
	Entrez ID	2335
	Gene name	fibronectin 1
	Synonyms	CIG\|FINC\|GFND2\|LETS\|MSF
	Gene type	protein_coding
	UniProtAcc	P02751

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Dataset with differentially expressed gene: FN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	1.26577	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.411011	1.58e-38
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	1.0996	1.64e-14
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.778889	3.72e-33
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.801528	8.60e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.392847	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.288739	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	1.11005	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	1.09597	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	1.54331	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.408146	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	1.5089	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.579283	4.48e-20
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.52963	0.00e+00

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Expression of FN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	B cells	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	B cells	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	CD4+ T cells	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	CD4+ T cells	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC06C3BA86F	FN1_integrin_a5b1_complex	FN1	NA	True	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC08F923F07	FN1_integrin_aVb1_complex	FN1	NA	True	Mono/Macro	Mast cells	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC06C3BA86F	FN1_integrin_a5b1_complex	FN1	NA	True	Mono/Macro	Mast cells	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	Mast cells	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC08F923F07	FN1_integrin_aVb1_complex	FN1	NA	True	Mono/Macro	Mono/Macro	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	NK cells	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	NK cells	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	pDCs	GSE169246_PacAteTissue	post	resistant
FN1	Mono/Macro	CPI-SC08F923F07	FN1_integrin_aVb1_complex	FN1	NA	True	Mono/Macro	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	NK cells	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	NK cells	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	pDCs	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	B cells	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	B cells	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	CD4+ T cells	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	CD4+ T cells	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC08F923F07	FN1_integrin_aVb1_complex	FN1	NA	True	Mono/Macro	Mast cells	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	Mast cells	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC06C3BA86F	FN1_integrin_a5b1_complex	FN1	NA	True	Mono/Macro	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	B cells	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	B cells	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	CD4+ T cells	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	CD4+ T cells	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	CD8+ T cells	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	CD8+ T cells	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC06C3BA86F	FN1_integrin_a5b1_complex	FN1	NA	True	Mono/Macro	Mono/Macro	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC08F923F07	FN1_integrin_aVb1_complex	FN1	NA	True	Mono/Macro	Mono/Macro	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	Mono/Macro	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	NK cells	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	NK cells	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC06C3BA86F	FN1_integrin_a5b1_complex	FN1	NA	True	Mono/Macro	cDCs	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC08F923F07	FN1_integrin_aVb1_complex	FN1	NA	True	Mono/Macro	cDCs	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	cDCs	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	pDCs	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	pDCs	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC06C3BA86F	FN1_integrin_a5b1_complex	FN1	NA	True	cDCs	Mono/Macro	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC08F923F07	FN1_integrin_aVb1_complex	FN1	NA	True	cDCs	Mono/Macro	GSE169246_PacTissue	post	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	B cells	GSE169246_PacTissue	pre	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	B cells	GSE169246_PacTissue	pre	resistant
FN1	Mono/Macro	CPI-SC0F96CE387	FN1_integrin_a4b1_complex	FN1	NA	True	Mono/Macro	CD4+ T cells	GSE169246_PacTissue	pre	resistant
FN1	Mono/Macro	CPI-SC034EE8AAA	FN1_integrin_a4b7_complex	FN1	NA	True	Mono/Macro	CD4+ T cells	GSE169246_PacTissue	pre	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
FN1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating FN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FN1	hsa-miR-3124-3p	98.6755	NM_001306129
FN1	hsa-miR-144-3p	97.3281	NM_212476
FN1	hsa-miR-4318	96.2582	NM_001306129
FN1	hsa-miR-4752	95.1938	NM_001306129
FN1	hsa-miR-4668-5p	95.1241	NM_212476
FN1	hsa-miR-200c-3p	93.838	NM_001306129
FN1	hsa-miR-200b-3p	93.838	NM_001306129
FN1	hsa-miR-429	93.838	NM_001306129
FN1	hsa-miR-3161	92.7517	NM_054034
FN1	hsa-miR-3685	92.4153	NM_001306129
FN1	hsa-miR-4516	92.3204	NM_001306129
FN1	hsa-miR-7-2-3p	92.0251	NM_054034
FN1	hsa-miR-7-1-3p	92.0251	NM_054034
FN1	hsa-miR-4531	91.6101	NM_001306129
FN1	hsa-miR-889-3p	89.7762	NM_212476
FN1	hsa-miR-6881-3p	89.7467	NM_212476
FN1	hsa-miR-12133	89.4202	NM_212476
FN1	hsa-miR-1271-5p	89.4202	NM_212476
FN1	hsa-miR-3148	89.4107	NM_212476
FN1	hsa-miR-7114-5p	89.2257	NM_001306129
FN1	hsa-miR-4434	88.9628	NM_001306129
FN1	hsa-miR-5703	88.9628	NM_001306129
FN1	hsa-miR-6882-5p	88.3626	NM_054034
FN1	hsa-miR-96-5p	88.2643	NM_212476
FN1	hsa-miR-4646-5p	87.9377	NM_054034
FN1	hsa-miR-298	87.2784	NM_001306129
FN1	hsa-miR-27a-3p	86.9535	NM_001306129
FN1	hsa-miR-27b-3p	86.9535	NM_001306129
FN1	hsa-miR-9985	86.9535	NM_001306129
FN1	hsa-miR-136-5p	86.8254	NM_212476
FN1	hsa-miR-3163	86.6686	NM_001306129
FN1	hsa-miR-3692-3p	85.9395	NM_212476
FN1	hsa-miR-5692a	85.3554	NM_001306129
FN1	hsa-miR-607	83.7315	NM_212476
FN1	hsa-miR-613	82.5567	NM_212476
FN1	hsa-miR-204-3p	82.528	NM_212476
FN1	hsa-miR-432-5p	82.3956	NM_001306129
FN1	hsa-miR-4711-3p	82.2037	NM_212476
FN1	hsa-miR-3671	82.1762	NM_001306129
FN1	hsa-miR-6830-3p	81.9914	NM_212476
FN1	hsa-miR-511-5p	81.8282	NM_212476
FN1	hsa-miR-3160-3p	81.5605	NM_001306129
FN1	hsa-miR-199a-3p	81.261	NM_001306129
FN1	hsa-miR-3129-5p	81.261	NM_001306129
FN1	hsa-miR-199b-3p	81.261	NM_001306129
FN1	hsa-miR-1-3p	80.2557	NM_212476
FN1	hsa-miR-206	80.2557	NM_212476
FN1	hsa-miR-892a	80.0489	NM_001306129

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Motifs and transcription factors (TFs) regulating FN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FN1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
FN1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
FN1	transfac_pro__M02089	E2F3 (directAnnotation).
FN1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
FN1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
FN1	tfdimers__MD00483	ZBTB14 (directAnnotation).
FN1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
FN1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
FN1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
FN1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
FN1	transfac_pro__M04887	TCF12 (directAnnotation).
FN1	metacluster_74.13	HNF1A; HNF1B (directAnnotation).
FN1	tfdimers__MD00371	PDX1; RUNX3 (directAnnotation).
FN1	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNNTTRCGYAAN_CAP	CEBPB; GCM1 (directAnnotation).
FN1	metacluster_74.11	HNF1B (inferredBy_Orthology).
FN1	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
FN1	metacluster_74.8	HNF1B (directAnnotation).
FN1	metacluster_74.10	HNF1B (directAnnotation).
FN1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
FN1	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
FN1	cisbp__M04023	CREB1 (directAnnotation).
FN1	tfdimers__MD00223	SOX9; TEAD1 (directAnnotation).
FN1	transfac_pro__M05898	ZSCAN4 (directAnnotation).
FN1	transfac_pro__M06180	ZNF445 (directAnnotation).
FN1	tfdimers__MD00545	ETS1; SOX10 (directAnnotation).
FN1	homer__TWGTCTGV_Smad3	SMAD3 (inferredBy_Orthology).
FN1	transfac_pro__M06728	PRDM5 (directAnnotation).
FN1	transfac_pro__M05418	ZNF521 (directAnnotation).
FN1	transfac_pro__M06246	ZNF177 (directAnnotation).
FN1	transfac_pro__M05842	ZBTB41 (inferredBy_Orthology).
FN1	tfdimers__MD00186	NFATC3; SPI1 (directAnnotation).
FN1	transfac_pro__M05612	ZNF189 (directAnnotation).
FN1	transfac_pro__M06402	ZNF493 (directAnnotation).
FN1	transfac_pro__M05877	ZNF467 (inferredBy_Orthology).
FN1	tfdimers__MD00095	ELF1; NEUROD1 (directAnnotation).
FN1	swissregulon__hs__ZKSCAN3	ZKSCAN3 (directAnnotation).
FN1	taipale_tf_pairs__CUX1_TBX3_AGGTGTGNNNNATCRAT_CAP_repr	CUX1; TBX3 (directAnnotation).
FN1	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
FN1	transfac_pro__M06158	ZNF157 (directAnnotation).
FN1	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
FN1	"Lanoteplase"	DB06245	biotech
FN1	"Ocriplasmin"	DB08888	biotech
FN1	"Zinc acetate"	DB14487	small molecule
FN1	"Zinc chloride"	DB14533	small molecule
FN1	"Zinc sulfate, unspecified form"	DB14548	small molecule
FN1	"Zinc"	DB01593	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."