Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FBXW7

Summary for FBXW7

Gene information	Gene symbol	FBXW7
	Ensembl ID	ENSG00000109670
	Entrez ID	55294
	Gene name	F-box and WD repeat domain containing 7
	Synonyms	AGO\|CDC4\|FBW7\|FBX30\|FBXW6\|FLJ11071\|SEL-10\|SEL10
	Gene type	protein_coding
	UniProtAcc	Q969H0

Top

Dataset with differentially expressed gene: FBXW7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.377194	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.294341	3.17e-16
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.566658	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.38219	0.00e+00

Top

Expression of FBXW7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to FBXW7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
FBXW7	Epigenetic Alteration of DNA, RNA or Protein
FBXW7	Unusual Activation of Pro-survival Pathway

Page: 1

Top

MicroRNAs (miRNA) regulating FBXW7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FBXW7	hsa-miR-223-3p	99.988	NM_033632
FBXW7	hsa-miR-4697-3p	99.889	NM_033632
FBXW7	hsa-miR-92b-3p	99.6686	NM_033632
FBXW7	hsa-miR-92a-3p	99.6686	NM_033632
FBXW7	hsa-miR-32-5p	99.6686	NM_033632
FBXW7	hsa-miR-363-3p	99.5884	NM_033632
FBXW7	hsa-miR-367-3p	99.5884	NM_033632
FBXW7	hsa-miR-25-3p	99.5884	NM_033632
FBXW7	hsa-miR-5693	99.0411	NM_033632
FBXW7	hsa-miR-27a-3p	98.9815	NM_033632
FBXW7	hsa-miR-27b-3p	98.9815	NM_033632
FBXW7	hsa-miR-9985	98.9815	NM_033632
FBXW7	hsa-miR-4516	98.3601	NM_033632
FBXW7	hsa-miR-200c-3p	97.9539	NM_033632
FBXW7	hsa-miR-200b-3p	97.9539	NM_033632
FBXW7	hsa-miR-429	97.9539	NM_033632
FBXW7	hsa-miR-4434	97.8689	NM_033632
FBXW7	hsa-miR-5703	97.8689	NM_033632
FBXW7	hsa-miR-107	97.6695	NM_033632
FBXW7	hsa-miR-103a-3p	97.6695	NM_033632
FBXW7	hsa-miR-4470	97.6397	NM_033632
FBXW7	hsa-miR-634	97.4085	NM_033632
FBXW7	hsa-miR-194-3p	97.3645	NM_033632
FBXW7	hsa-miR-424-5p	97.2034	NM_033632
FBXW7	hsa-miR-6838-5p	97.2034	NM_033632
FBXW7	hsa-miR-497-5p	97.2034	NM_033632
FBXW7	hsa-miR-16-5p	97.0316	NM_033632
FBXW7	hsa-miR-15a-5p	97.0316	NM_033632
FBXW7	hsa-miR-195-5p	97.0316	NM_033632
FBXW7	hsa-miR-15b-5p	97.0316	NM_033632
FBXW7	hsa-miR-627-3p	96.7303	NM_033632
FBXW7	hsa-miR-3613-3p	96.6151	NM_033632
FBXW7	hsa-miR-4775	96.4276	NM_033632
FBXW7	hsa-miR-4524a-5p	95.9453	NM_033632
FBXW7	hsa-miR-4524b-5p	95.9453	NM_033632
FBXW7	hsa-miR-204-5p	95.1785	NM_033632
FBXW7	hsa-miR-211-5p	95.1785	NM_033632
FBXW7	hsa-miR-182-5p	94.9532	NM_033632
FBXW7	hsa-miR-4693-5p	94.8589	NM_033632
FBXW7	hsa-miR-922	94.5175	NM_033632
FBXW7	hsa-miR-4325	94.0456	NM_033632
FBXW7	hsa-miR-4531	93.4831	NM_033632
FBXW7	hsa-miR-188-5p	93.394	NM_033632
FBXW7	hsa-miR-6866-3p	93.394	NM_033632
FBXW7	hsa-miR-503-5p	93.3266	NM_033632
FBXW7	hsa-miR-646	93.2555	NM_033632
FBXW7	hsa-miR-374b-3p	93.1217	NM_033632
FBXW7	hsa-miR-548ar-3p	93.0204	NM_033632
FBXW7	hsa-miR-5692a	92.7084	NM_033632
FBXW7	hsa-miR-513a-5p	92.5904	NM_033632

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating FBXW7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FBXW7	metacluster_3.14	WT1; WT1 (directAnnotation).
FBXW7	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
FBXW7	transfac_pro__M01837	KLF11 (directAnnotation).
FBXW7	hdpi__TP73	TP73 (directAnnotation).
FBXW7	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FBXW7	transfac_pro__M07310	SP5 (directAnnotation).
FBXW7	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
FBXW7	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
FBXW7	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
FBXW7	jaspar__MA0748.2	YY2 (directAnnotation).
FBXW7	swissregulon__hs__KLF6	KLF6 (directAnnotation).
FBXW7	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
FBXW7	metacluster_7.13	ZFX (directAnnotation).
FBXW7	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
FBXW7	transfac_pro__M01175	ZBTB7B (directAnnotation).
FBXW7	transfac_pro__M00716	ZBTB14 (directAnnotation).
FBXW7	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
FBXW7	jaspar__MA1122.1	TFDP1 (directAnnotation).
FBXW7	transfac_pro__M07297	MAZ (directAnnotation).
FBXW7	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
FBXW7	cisbp__M00968	MTF2 (directAnnotation).
FBXW7	metacluster_163.2	ZNF682 (directAnnotation).
FBXW7	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FBXW7	transfac_pro__M04916	TAF1 (directAnnotation).
FBXW7	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
FBXW7	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
FBXW7	transfac_pro__M00938	E2F1 (directAnnotation).
FBXW7	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FBXW7	transfac_pro__M02090	E2F4 (directAnnotation).
FBXW7	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
FBXW7	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
FBXW7	swissregulon__hs__CHD1	CHD1 (directAnnotation).
FBXW7	transfac_pro__M01303	SP1 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."

1	miR-363 promotes proliferation and chemo-resistance of human gastric cancer via targeting of FBW7 ubiquitin ligase expression
2	MiR-223 promotes the doxorubicin resistance of colorectal cancer cells via regulating epithelial-mesenchymal transition by targeting FBXW7
3	Sensitivity of non-small cell lung cancer to erlotinib is regulated by the Notch/miR-223/FBXW7 pathway
4	FBW7�mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation
5	FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors