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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAR1

Summary for FAR1

Gene information	Gene symbol	FAR1
	Ensembl ID	ENSG00000197601
	Entrez ID	84188
	Gene name	fatty acyl-CoA reductase 1
	Synonyms	FLJ22728\|MLSTD2\|SDR10E1
	Gene type	protein_coding
	UniProtAcc	Q8WVX9

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Dataset with differentially expressed gene: FAR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.588179	1.63e-32

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Expression of FAR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAR1	hsa-miR-548as-3p	97.9836	NM_032228
FAR1	hsa-miR-548p	97.3087	NM_032228
FAR1	hsa-miR-3662	95.9177	NM_032228
FAR1	hsa-miR-3910	94.7677	NM_032228
FAR1	hsa-miR-4426	93.7184	NM_032228
FAR1	hsa-miR-3163	92.6218	NM_032228
FAR1	hsa-miR-4647	91.2147	NM_032228
FAR1	hsa-miR-4662b	91.2147	NM_032228
FAR1	hsa-miR-6875-3p	90.8994	NM_032228
FAR1	hsa-miR-124-3p	89.9715	NM_032228
FAR1	hsa-miR-506-3p	89.9715	NM_032228
FAR1	hsa-miR-382-3p	89.8755	NM_032228
FAR1	hsa-miR-498-5p	89.6345	NM_032228
FAR1	hsa-miR-4728-3p	89.471	NM_032228
FAR1	hsa-miR-1178-5p	88.7117	NM_032228
FAR1	hsa-miR-493-5p	88.6559	NM_032228
FAR1	hsa-miR-676-5p	88.5681	NM_032228
FAR1	hsa-miR-3688-3p	88.0306	NM_032228
FAR1	hsa-miR-1305	87.2331	NM_032228
FAR1	hsa-miR-6507-5p	86.9955	NM_032228
FAR1	hsa-miR-12123	86.9367	NM_032228
FAR1	hsa-miR-548c-3p	86.8979	NM_032228
FAR1	hsa-miR-5696	86.1679	NM_032228
FAR1	hsa-miR-590-3p	85.9671	NM_032228
FAR1	hsa-miR-124-5p	85.8001	NM_032228
FAR1	hsa-miR-299-5p	85.5708	NM_032228
FAR1	hsa-miR-3613-3p	85.3938	NM_032228
FAR1	hsa-miR-520e-5p	85.0126	NM_032228
FAR1	hsa-miR-155-5p	84.5235	NM_032228
FAR1	hsa-miR-664a-3p	83.6175	NM_032228
FAR1	hsa-miR-3614-3p	82.8687	NM_032228
FAR1	hsa-miR-4282	81.906	NM_032228
FAR1	hsa-miR-8065	81.3083	NM_032228
FAR1	hsa-miR-1237-3p	81.2286	NM_032228
FAR1	hsa-miR-888-5p	81.0687	NM_032228
FAR1	hsa-miR-143-3p	81.0185	NM_032228
FAR1	hsa-miR-4770	81.0185	NM_032228
FAR1	hsa-miR-548aj-5p	80.9099	NM_032228
FAR1	hsa-miR-548x-5p	80.9099	NM_032228
FAR1	hsa-miR-548g-5p	80.9099	NM_032228
FAR1	hsa-miR-548f-5p	80.9099	NM_032228
FAR1	hsa-miR-8485	80.3479	NM_032228
FAR1	hsa-miR-144-5p	80.2479	NM_032228
FAR1	hsa-miR-30d-3p	80.2334	NM_032228
FAR1	hsa-miR-30a-3p	80.2334	NM_032228
FAR1	hsa-miR-30e-3p	80.2334	NM_032228

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Motifs and transcription factors (TFs) regulating FAR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAR1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FAR1	transfac_pro__M04893	TAF1 (directAnnotation).
FAR1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
FAR1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
FAR1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
FAR1	kznf__EGR2_Barrera2016.3_PBM	EGR2 (directAnnotation).
FAR1	metacluster_23.8	GLIS1; GLIS1; GLIS1; GLIS2; GLIS2; GLIS2; GLIS2 (directAnnotation). GLIS2; GLIS3; ZXDA; ZXDB; ZXDC (inferredBy_Orthology).
FAR1	transfac_pro__M00986	CHURC1 (directAnnotation).
FAR1	metacluster_182.2	GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM2; GCM2 (inferredBy_Orthology).
FAR1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FAR1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
FAR1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
FAR1	cisbp__M00249	WT1 (directAnnotation).
FAR1	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
FAR1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
FAR1	transfac_public__M00373	PAX4 (directAnnotation).
FAR1	transfac_pro__M01714	KLF15 (directAnnotation).
FAR1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
FAR1	cisbp__M00135	ZBTB7B (inferredBy_Orthology).
FAR1	tfdimers__MD00366	MTF1; OVOL2 (directAnnotation).
FAR1	transfac_pro__M00938	E2F1 (directAnnotation).
FAR1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FAR1	transfac_pro__M12667	GPBP1L1 (directAnnotation).
FAR1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
FAR1	transfac_pro__M07310	SP5 (directAnnotation).
FAR1	cisbp__M00341	PAX6 (directAnnotation).
FAR1	swissregulon__hs__PATZ1	PATZ1 (directAnnotation).
FAR1	metacluster_159.3	ARID3A; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCF; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; CTCFL; HMGXB4; KLF16; MBD1; RAD21; RAD21; RAD21; RXRA; SMC3; SMC3; ZNF576; ZNF654; ZNF764 (directAnnotation). CTCF; CTCF; CTCF; CTCF; CTCFL (inferredBy_Orthology).
FAR1	transfac_pro__M08818	KLF8 (directAnnotation).
FAR1	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."