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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM3C

Summary for FAM3C

Gene information	Gene symbol	FAM3C
	Ensembl ID	ENSG00000196937
	Entrez ID	10447
	Gene name	FAM3 metabolism regulating signaling molecule C
	Synonyms	GS3876\|ILEI
	Gene type	protein_coding
	UniProtAcc	Q92520

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Dataset with differentially expressed gene: FAM3C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.648039	2.04e-02
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.430195	4.76e-13
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.482129	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.334596	7.49e-22
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.473559	4.23e-26
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.284159	3.44e-09
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.651591	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.7802	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.574159	0.00e+00

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Expression of FAM3C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM3C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM3C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM3C	hsa-miR-299-5p	98.086	NM_001040020
FAM3C	hsa-miR-4775	97.6488	NM_001040020
FAM3C	hsa-miR-4699-3p	97.3909	NM_001040020
FAM3C	hsa-let-7f-1-3p	96.6089	NM_001040020
FAM3C	hsa-let-7a-3p	96.6089	NM_001040020
FAM3C	hsa-miR-98-3p	96.6089	NM_001040020
FAM3C	hsa-let-7b-3p	96.6089	NM_001040020
FAM3C	hsa-miR-18a-5p	95.9934	NM_001040020
FAM3C	hsa-miR-18b-5p	95.9934	NM_001040020
FAM3C	hsa-miR-524-5p	95.9257	NM_001040020
FAM3C	hsa-miR-520d-5p	95.9257	NM_001040020
FAM3C	hsa-miR-302f	95.2412	NM_001040020
FAM3C	hsa-miR-5692a	95.0919	NM_001040020
FAM3C	hsa-miR-7154-5p	94.2676	NM_001040020
FAM3C	hsa-miR-4735-3p	94.2433	NM_001040020
FAM3C	hsa-miR-4276	93.048	NM_001040020
FAM3C	hsa-miR-605-5p	92.64	NM_001040020
FAM3C	hsa-miR-4703-5p	92.3466	NM_001040020
FAM3C	hsa-miR-3668	91.8882	NM_001040020
FAM3C	hsa-miR-466	91.3803	NM_001040020
FAM3C	hsa-miR-4766-3p	91.0728	NM_001040020
FAM3C	hsa-miR-3658	91.0715	NM_001040020
FAM3C	hsa-miR-3140-3p	90.9857	NM_001040020
FAM3C	hsa-miR-4262	90.3796	NM_001040020
FAM3C	hsa-miR-21-5p	90.0032	NM_001040020
FAM3C	hsa-miR-181d-5p	89.6336	NM_001040020
FAM3C	hsa-miR-181b-5p	89.6336	NM_001040020
FAM3C	hsa-miR-181c-5p	89.6336	NM_001040020
FAM3C	hsa-miR-181a-5p	89.6336	NM_001040020
FAM3C	hsa-miR-498-3p	89.5378	NM_001040020
FAM3C	hsa-miR-3942-5p	89.0164	NM_001040020
FAM3C	hsa-miR-3613-3p	88.4756	NM_001040020
FAM3C	hsa-miR-4289	88.4067	NM_001040020
FAM3C	hsa-miR-3941	88.1118	NM_001040020
FAM3C	hsa-miR-218-5p	87.0889	NM_001040020
FAM3C	hsa-miR-590-5p	86.6521	NM_001040020
FAM3C	hsa-miR-95-5p	85.5423	NM_001040020
FAM3C	hsa-miR-4511	85.4518	NM_001040020
FAM3C	hsa-miR-5196-5p	85.2265	NM_001040020
FAM3C	hsa-miR-4747-5p	85.2265	NM_001040020
FAM3C	hsa-miR-548ar-3p	85.198	NM_001040020
FAM3C	hsa-miR-500a-5p	84.498	NM_001040020
FAM3C	hsa-miR-4308	83.8221	NM_001040020
FAM3C	hsa-miR-548az-3p	83.3647	NM_001040020
FAM3C	hsa-miR-548a-3p	83.3647	NM_001040020
FAM3C	hsa-miR-548bc	83.3647	NM_001040020
FAM3C	hsa-miR-548f-3p	83.3647	NM_001040020
FAM3C	hsa-miR-548e-3p	83.3647	NM_001040020
FAM3C	hsa-miR-892a	81.5649	NM_001040020
FAM3C	hsa-miR-8063	81.3814	NM_001040020

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Motifs and transcription factors (TFs) regulating FAM3C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM3C	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
FAM3C	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
FAM3C	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
FAM3C	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
FAM3C	cisbp__M02645	ETS1 (directAnnotation).
FAM3C	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
FAM3C	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
FAM3C	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
FAM3C	hdpi__ELF2	ELF2 (directAnnotation).
FAM3C	swissregulon__hs__ELK1	ELK1 (directAnnotation).
FAM3C	metacluster_183.4	ETS1 (inferredBy_Orthology).
FAM3C	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
FAM3C	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
FAM3C	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
FAM3C	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
FAM3C	transfac_pro__M04862	NRF1 (directAnnotation).
FAM3C	metacluster_81.7	CREB1 (directAnnotation).
FAM3C	transfac_pro__M01298	MECP2 (directAnnotation).
FAM3C	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
FAM3C	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
FAM3C	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
FAM3C	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
FAM3C	jaspar__MA0502.2	NFYB (directAnnotation).
FAM3C	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
FAM3C	swissregulon__hs__ETV6	ETV6 (directAnnotation).
FAM3C	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
FAM3C	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
FAM3C	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
FAM3C	transfac_pro__M12697	ZNF142 (directAnnotation).
FAM3C	cisbp__M00341	PAX6 (directAnnotation).
FAM3C	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
FAM3C	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FAM3C	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FAM3C	cisbp__M07938	E2F1 (directAnnotation).
FAM3C	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
FAM3C	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
FAM3C	jaspar__MA1122.1	TFDP1 (directAnnotation).
FAM3C	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
FAM3C	transfac_pro__M01175	ZBTB7B (directAnnotation).
FAM3C	metacluster_3.14	WT1; WT1 (directAnnotation).
FAM3C	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
FAM3C	transfac_pro__M01253	CNOT3 (directAnnotation).
FAM3C	transfac_pro__M02090	E2F4 (directAnnotation).
FAM3C	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
FAM3C	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
FAM3C	transfac_pro__M01303	SP1 (directAnnotation).
FAM3C	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
FAM3C	metacluster_163.2	ZNF682 (directAnnotation).
FAM3C	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
FAM3C	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."