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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM118A

Summary for FAM118A

Gene information	Gene symbol	FAM118A
	Ensembl ID	ENSG00000100376
	Entrez ID	55007
	Gene name	family with sequence similarity 118 member A
	Synonyms	bK268H5.C22.4\|C22orf8\|FLJ20635
	Gene type	protein_coding
	UniProtAcc	Q9NWS6

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Dataset with differentially expressed gene: FAM118A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.274956	2.72e-21
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.383823	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.476869	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	0.780398	4.63e-02
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.494279	4.80e-34
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.472661	8.19e-33
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.41072	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.295946	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.629357	8.35e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.361375	5.06e-24
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	-0.411989	3.50e-08

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Expression of FAM118A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM118A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM118A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM118A	hsa-miR-3977	97.7537	NM_001104595
FAM118A	hsa-miR-544b	95.4863	NM_001104595
FAM118A	hsa-miR-4670-3p	94.322	NM_001104595
FAM118A	hsa-miR-3160-5p	92.6238	NM_001104595
FAM118A	hsa-miR-2116-5p	90.2481	NM_001104595
FAM118A	hsa-miR-590-3p	90.0278	NM_001104595
FAM118A	hsa-miR-5581-3p	87.01	NM_001104595
FAM118A	hsa-miR-3622a-3p	86.4734	NM_001104595
FAM118A	hsa-miR-3622b-3p	86.4734	NM_001104595
FAM118A	hsa-miR-3613-3p	86.0762	NM_001104595
FAM118A	hsa-miR-4319	84.0949	NM_001104595
FAM118A	hsa-miR-4282	83.1922	NM_001104595
FAM118A	hsa-miR-10397-5p	83.0681	NM_001104595
FAM118A	hsa-miR-125b-5p	82.647	NM_001104595
FAM118A	hsa-miR-125a-5p	82.647	NM_001104595
FAM118A	hsa-miR-6077	80.9435	NM_001104595
FAM118A	hsa-miR-1266-3p	80.553	NM_001104595
FAM118A	hsa-miR-345-5p	80.5085	NM_001104595
FAM118A	hsa-miR-12122	80.0432	NM_001104595

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Motifs and transcription factors (TFs) regulating FAM118A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM118A	transfac_pro__M06104	ZNF16 (directAnnotation).
FAM118A	transfac_pro__M06391	ZNF836 (directAnnotation).
FAM118A	hdpi__JDP2	JDP2 (directAnnotation).
FAM118A	cisbp__M00221	SNAI2 (directAnnotation).
FAM118A	transfac_pro__M05600	IKZF3 (inferredBy_Orthology).
FAM118A	metacluster_97.2	GTF3A (inferredBy_Orthology).
FAM118A	tfdimers__MD00434	MYCN; YY1 (directAnnotation).
FAM118A	tfdimers__MD00084	ARID3A; NKX2-4 (directAnnotation).
FAM118A	transfac_public__M00040	ATF2 (directAnnotation).
FAM118A	kznf__ZNF432_Imbeault2017_RP_RCADE	ZNF432 (directAnnotation).
FAM118A	transfac_pro__M05994	ZNF230 (directAnnotation).
FAM118A	taipale_tf_pairs__TEAD4_ELK3_NCCGGAANNNNNNNMATWCC_CAP_repr	ELK3; TEAD4 (directAnnotation).
FAM118A	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
FAM118A	transfac_pro__M01861	ATF1 (directAnnotation).
FAM118A	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
FAM118A	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
FAM118A	transfac_public__M00039	CREB1 (directAnnotation).
FAM118A	metacluster_111.5	E4F1; E4F1 (directAnnotation).
FAM118A	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
FAM118A	hdpi__NRL	NRL (directAnnotation).
FAM118A	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
FAM118A	transfac_pro__M04817	ZBTB33 (directAnnotation).
FAM118A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
FAM118A	transfac_pro__M07329	SP7 (directAnnotation).
FAM118A	metacluster_3.14	WT1; WT1 (directAnnotation).
FAM118A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
FAM118A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
FAM118A	transfac_pro__M05402	BCL6B (directAnnotation).
FAM118A	hdpi__PDLIM5	PDLIM5 (directAnnotation).
FAM118A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."