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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM114A1

Summary for FAM114A1

Gene information	Gene symbol	FAM114A1
	Ensembl ID	ENSG00000197712
	Entrez ID	92689
	Gene name	family with sequence similarity 114 member A1
	Synonyms	Noxp20
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FAM114A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.361184	1.31e-12
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.362946	4.20e-45
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.283924	4.86e-31

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Expression of FAM114A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM114A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM114A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM114A1	hsa-miR-4768-3p	98.1593	NM_138389
FAM114A1	hsa-miR-101-3p	95.5761	NM_138389
FAM114A1	hsa-miR-2681-5p	90.409	NM_138389
FAM114A1	hsa-miR-330-3p	90.1653	NM_138389
FAM114A1	hsa-miR-4789-5p	89.9124	NM_138389
FAM114A1	hsa-miR-2117	89.25	NM_138389
FAM114A1	hsa-miR-8066	89.2105	NM_138389
FAM114A1	hsa-miR-513a-3p	88.9265	NM_138389
FAM114A1	hsa-miR-513c-3p	88.9265	NM_138389
FAM114A1	hsa-miR-493-5p	88.6267	NM_138389
FAM114A1	hsa-miR-4677-5p	88.063	NM_138389
FAM114A1	hsa-miR-6514-3p	87.394	NM_138389
FAM114A1	hsa-miR-4799-5p	87.261	NM_138389
FAM114A1	hsa-miR-6513-5p	86.3353	NM_138389
FAM114A1	hsa-miR-4803	85.5331	NM_138389
FAM114A1	hsa-miR-494-3p	85.1692	NM_138389
FAM114A1	hsa-miR-3606-3p	85.0984	NM_138389
FAM114A1	hsa-miR-4775	84.2015	NM_138389
FAM114A1	hsa-miR-8084	84.007	NM_138389
FAM114A1	hsa-miR-3613-3p	82.5991	NM_138389
FAM114A1	hsa-miR-5100	81.6496	NM_138389
FAM114A1	hsa-miR-6832-3p	81.0055	NM_138389
FAM114A1	hsa-miR-19b-3p	80.9998	NM_138389
FAM114A1	hsa-miR-19a-3p	80.9998	NM_138389
FAM114A1	hsa-miR-371b-5p	80.3219	NM_138389
FAM114A1	hsa-miR-616-5p	80.3219	NM_138389
FAM114A1	hsa-miR-373-5p	80.3219	NM_138389

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Motifs and transcription factors (TFs) regulating FAM114A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM114A1	transfac_pro__M01199	TRIM28 (directAnnotation).
FAM114A1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
FAM114A1	metacluster_151.2	ZNF23 (directAnnotation).
FAM114A1	transfac_pro__M03806	ZBTB7C (directAnnotation).
FAM114A1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FAM114A1	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
FAM114A1	transfac_pro__M06084	ZNF208 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."