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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM102B

Summary for FAM102B

Gene information	Gene symbol	FAM102B
	Ensembl ID	ENSG00000162636
	Entrez ID	284611
	Gene name	family with sequence similarity 102 member B
	Synonyms	DKFZp779B126\|SYM-3B
	Gene type	protein_coding
	UniProtAcc	Q5T8I3

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Dataset with differentially expressed gene: FAM102B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.60053	2.94e-03
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.361263	1.63e-18
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.43496	0.00e+00

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Expression of FAM102B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM102B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM102B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM102B	hsa-miR-6895-3p	98.7944	NM_001010883
FAM102B	hsa-miR-12136	97.4829	NM_001010883
FAM102B	hsa-miR-1277-5p	96.9898	NM_001010883
FAM102B	hsa-miR-3163	96.8037	NM_001010883
FAM102B	hsa-miR-515-5p	93.778	NM_001010883
FAM102B	hsa-miR-519e-5p	93.778	NM_001010883
FAM102B	hsa-miR-6787-3p	93.286	NM_001010883
FAM102B	hsa-miR-11181-5p	93.0581	NM_001010883
FAM102B	hsa-miR-4256	93.0581	NM_001010883
FAM102B	hsa-miR-493-3p	92.6246	NM_001010883
FAM102B	hsa-miR-5695	91.3519	NM_001010883
FAM102B	hsa-miR-892a	90.4925	NM_001010883
FAM102B	hsa-miR-4482-3p	90.2782	NM_001010883
FAM102B	hsa-miR-3182	90.0716	NM_001010883
FAM102B	hsa-miR-520d-5p	88.7688	NM_001010883
FAM102B	hsa-miR-524-5p	88.7688	NM_001010883
FAM102B	hsa-miR-12129	87.1294	NM_001010883
FAM102B	hsa-miR-5011-5p	87.1061	NM_001010883
FAM102B	hsa-miR-3617-5p	87.0899	NM_001010883
FAM102B	hsa-miR-6881-3p	86.8453	NM_001010883
FAM102B	hsa-miR-3159	86.6615	NM_001010883
FAM102B	hsa-miR-6830-3p	86.5045	NM_001010883
FAM102B	hsa-miR-4773	85.8055	NM_001010883
FAM102B	hsa-miR-5692b	85.6617	NM_001010883
FAM102B	hsa-miR-5692c	85.6617	NM_001010883
FAM102B	hsa-miR-641	85.2481	NM_001010883
FAM102B	hsa-miR-4766-5p	84.9535	NM_001010883
FAM102B	hsa-miR-3662	84.8545	NM_001010883
FAM102B	hsa-miR-4261	84.8363	NM_001010883
FAM102B	hsa-miR-34b-3p	84.394	NM_001010883
FAM102B	hsa-miR-3059-3p	84.0575	NM_001010883
FAM102B	hsa-miR-4717-3p	83.9315	NM_001010883
FAM102B	hsa-miR-1250-3p	83.6526	NM_001010883
FAM102B	hsa-miR-629-3p	83.2686	NM_001010883
FAM102B	hsa-miR-4791	83.1911	NM_001010883
FAM102B	hsa-miR-7110-3p	83.0588	NM_001010883
FAM102B	hsa-miR-3201	82.9873	NM_001010883
FAM102B	hsa-miR-6873-3p	82.4908	NM_001010883
FAM102B	hsa-miR-627-5p	82.1614	NM_001010883
FAM102B	hsa-miR-8063	82.0827	NM_001010883
FAM102B	hsa-miR-3059-5p	82.0696	NM_001010883
FAM102B	hsa-miR-4660	81.6212	NM_001010883
FAM102B	hsa-miR-3691-3p	81.5945	NM_001010883
FAM102B	hsa-miR-3121-3p	80.1378	NM_001010883
FAM102B	hsa-miR-301b-5p	80.1064	NM_001010883
FAM102B	hsa-miR-301a-5p	80.1064	NM_001010883

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Motifs and transcription factors (TFs) regulating FAM102B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM102B	transfac_pro__M01199	TRIM28 (directAnnotation).
FAM102B	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
FAM102B	metacluster_151.2	ZNF23 (directAnnotation).
FAM102B	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FAM102B	transfac_pro__M03806	ZBTB7C (directAnnotation).
FAM102B	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."