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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ELL2

Summary for ELL2

Gene information	Gene symbol	ELL2
	Ensembl ID	ENSG00000118985
	Entrez ID	22936
	Gene name	elongation factor for RNA polymerase II 2
	Synonyms	MRCCAT1
	Gene type	protein_coding
	UniProtAcc	O00472

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Dataset with differentially expressed gene: ELL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.28669	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.253647	2.48e-12
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.396183	2.05e-20
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.256283	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.457099	2.31e-32
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.331855	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.399446	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.454028	2.97e-08
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.295116	6.09e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.373137	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	0.767623	4.24e-03
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.502345	1.89e-24
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.354192	0.00e+00

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Expression of ELL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ELL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ELL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ELL2	hsa-miR-203a-3p	99.4907	NM_012081
ELL2	hsa-miR-5688	99.1287	NM_012081
ELL2	hsa-miR-495-3p	98.4372	NM_012081
ELL2	hsa-miR-30a-5p	97.943	NM_012081
ELL2	hsa-miR-30b-5p	97.943	NM_012081
ELL2	hsa-miR-30c-5p	97.943	NM_012081
ELL2	hsa-miR-30d-5p	97.943	NM_012081
ELL2	hsa-miR-30e-5p	97.943	NM_012081
ELL2	hsa-miR-3910	97.6217	NM_012081
ELL2	hsa-miR-153-5p	97.4527	NM_012081
ELL2	hsa-miR-4694-3p	97.2284	NM_012081
ELL2	hsa-miR-3613-3p	97.0546	NM_012081
ELL2	hsa-miR-200b-3p	97.0265	NM_012081
ELL2	hsa-miR-200c-3p	97.0265	NM_012081
ELL2	hsa-miR-429	97.0265	NM_012081
ELL2	hsa-miR-646	96.6363	NM_012081
ELL2	hsa-miR-510-3p	96.425	NM_012081
ELL2	hsa-miR-2113	96.4131	NM_012081
ELL2	hsa-miR-5692a	95.9938	NM_012081
ELL2	hsa-miR-1305	95.5018	NM_012081
ELL2	hsa-miR-3714	95.1148	NM_012081
ELL2	hsa-miR-5011-5p	94.9915	NM_012081
ELL2	hsa-miR-6828-5p	94.9298	NM_012081
ELL2	hsa-miR-548a-5p	94.7618	NM_012081
ELL2	hsa-miR-548ar-5p	94.7618	NM_012081
ELL2	hsa-miR-548ab	94.5223	NM_012081
ELL2	hsa-miR-506-3p	94.4761	NM_012081
ELL2	hsa-miR-124-3p	94.4761	NM_012081
ELL2	hsa-miR-3688-3p	94.3466	NM_012081
ELL2	hsa-miR-4477b	93.8966	NM_012081
ELL2	hsa-miR-7-1-3p	93.8337	NM_012081
ELL2	hsa-miR-7-2-3p	93.8337	NM_012081
ELL2	hsa-miR-6124	93.7009	NM_012081
ELL2	hsa-miR-559	93.4925	NM_012081
ELL2	hsa-miR-21-3p	93.4102	NM_012081
ELL2	hsa-miR-122b-3p	93.4102	NM_012081
ELL2	hsa-miR-548as-5p	93.3841	NM_012081
ELL2	hsa-miR-548j-5p	93.3841	NM_012081
ELL2	hsa-miR-548au-5p	93.3841	NM_012081
ELL2	hsa-miR-548ak	93.3841	NM_012081
ELL2	hsa-miR-548w	93.3841	NM_012081
ELL2	hsa-miR-548bb-5p	93.3841	NM_012081
ELL2	hsa-miR-548d-5p	93.3841	NM_012081
ELL2	hsa-miR-548am-5p	93.3841	NM_012081
ELL2	hsa-miR-548ay-5p	93.3841	NM_012081
ELL2	hsa-miR-548ap-5p	93.3841	NM_012081
ELL2	hsa-miR-548ad-5p	93.3841	NM_012081
ELL2	hsa-miR-548h-5p	93.3841	NM_012081
ELL2	hsa-miR-548o-5p	93.3841	NM_012081
ELL2	hsa-miR-548i	93.3841	NM_012081

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Motifs and transcription factors (TFs) regulating ELL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ELL2	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ELL2	transfac_pro__M06488	ZNF595 (directAnnotation).
ELL2	metacluster_131.3	ZNF436 (inferredBy_Orthology).
ELL2	metacluster_58.10	PAX3; PAX7 (directAnnotation).
ELL2	transfac_pro__M12586	MYBL2 (directAnnotation).
ELL2	metacluster_175.6	GRHL1; GRHL1; GRHL1; GRHL1; TFCP2 (directAnnotation).
ELL2	transfac_pro__M06426	ZNF761 (directAnnotation).
ELL2	transfac_pro__M06646	ZNF607 (directAnnotation).
ELL2	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
ELL2	metacluster_155.10	ZNF263; ZNF684; ZNF684; ZNF684; ZNF684 (directAnnotation).
ELL2	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
ELL2	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
ELL2	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
ELL2	transfac_pro__M01864	ATF4 (directAnnotation).
ELL2	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
ELL2	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
ELL2	transfac_pro__M06208	ZNF460 (directAnnotation).
ELL2	transfac_public__M00041	ATF2; JUN (directAnnotation).
ELL2	transfac_pro__M02279	CREB1 (directAnnotation).
ELL2	transfac_public__M00114	CREB1 (directAnnotation).
ELL2	jaspar__MA1106.1	HIF1A (directAnnotation).
ELL2	transfac_pro__M08190	AR (directAnnotation).
ELL2	transfac_pro__M05985	ZNF394 (inferredBy_Orthology).
ELL2	dbtfbs__ZNF664_HEK293_ENCSR714LZQ_merged_N1	ZNF664 (directAnnotation).
ELL2	transfac_pro__M06582	ZNF75A (directAnnotation).
ELL2	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
ELL2	metacluster_162.5	NR1D1; NR1D1; RORA; RORA; RORA; RORA; RORA; RORC; RORC (directAnnotation). NR1D1; PPARG; RORA; RORC (inferredBy_Orthology).
ELL2	transfac_public__M00040	ATF2 (directAnnotation).
ELL2	transfac_pro__M07981	ATF3 (inferredBy_Orthology).
ELL2	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
ELL2	transfac_pro__M02089	E2F3 (directAnnotation).
ELL2	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
ELL2	hdpi__NRL	NRL (directAnnotation).
ELL2	transfac_pro__M04817	ZBTB33 (directAnnotation).
ELL2	transfac_pro__M01199	TRIM28 (directAnnotation).
ELL2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ELL2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ELL2	transfac_pro__M00716	ZBTB14 (directAnnotation).
ELL2	cisbp__M07938	E2F1 (directAnnotation).
ELL2	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
ELL2	transfac_pro__M01253	CNOT3 (directAnnotation).
ELL2	transfac_pro__M07310	SP5 (directAnnotation).
ELL2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ELL2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ELL2	hdpi__RARA	RARA (directAnnotation).
ELL2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ELL2	transfac_pro__M04893	TAF1 (directAnnotation).
ELL2	hdpi__PDLIM5	PDLIM5 (directAnnotation).
ELL2	hdpi__HTATIP2	HTATIP2 (directAnnotation).
ELL2	hdpi__OTUD4	OTUD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."