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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: EIF2AK2

Summary for EIF2AK2

Gene information	Gene symbol	EIF2AK2
	Ensembl ID	ENSG00000055332
	Entrez ID	5610
	Gene name	eukaryotic translation initiation factor 2 alpha kinase 2
	Synonyms	PKR\|PPP1R83\|PRKR
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: EIF2AK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.431048	8.39e-31
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.440634	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	-0.353506	4.39e-03
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	-0.266775	4.33e-10
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	-0.332346	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	0.432962	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.588401	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.457348	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	B cells	0.277938	7.54e-28
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.325642	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	cDCs	-0.29526	3.08e-02
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.25061	1.98e-10
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.481961	1.25e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.272231	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.469337	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.258779	2.15e-18

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Expression of EIF2AK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EIF2AK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EIF2AK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EIF2AK2	hsa-miR-633	92.9135	NM_001135651
EIF2AK2	hsa-miR-548au-3p	92.5731	NM_001135651
EIF2AK2	hsa-miR-3158-5p	90.581	NM_001135651
EIF2AK2	hsa-miR-511-5p	90.3457	NM_001135651
EIF2AK2	hsa-miR-328-3p	87.4844	NM_001135651
EIF2AK2	hsa-miR-8065	87.3015	NM_001135651
EIF2AK2	hsa-miR-6851-3p	86.755	NM_001135651
EIF2AK2	hsa-miR-548ar-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548d-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548ap-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548bb-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-559	86.6238	NM_001135651
EIF2AK2	hsa-miR-548o-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548am-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548w	86.6238	NM_001135651
EIF2AK2	hsa-miR-548c-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548ad-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548b-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548ay-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548ak	86.6238	NM_001135651
EIF2AK2	hsa-miR-548i	86.6238	NM_001135651
EIF2AK2	hsa-miR-548h-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548y	86.6238	NM_001135651
EIF2AK2	hsa-miR-548au-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548ab	86.6238	NM_001135651
EIF2AK2	hsa-miR-548j-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548aq-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548ae-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548as-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-548a-5p	86.6238	NM_001135651
EIF2AK2	hsa-miR-4316	84.954	NM_001135651
EIF2AK2	hsa-miR-1911-5p	83.8183	NM_001135651
EIF2AK2	hsa-miR-1827	83.4474	NM_001135651
EIF2AK2	hsa-miR-5586-5p	83.3435	NM_001135651
EIF2AK2	hsa-miR-4326	81.6853	NM_001135651
EIF2AK2	hsa-miR-3157-3p	80.4077	NM_001135651

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Motifs and transcription factors (TFs) regulating EIF2AK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EIF2AK2	tfdimers__MD00095	ELF1; NEUROD1 (directAnnotation).
EIF2AK2	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
EIF2AK2	tfdimers__MD00143	IKZF1; MZF1 (directAnnotation).
EIF2AK2	swissregulon__hs__RUNX2	RUNX2 (directAnnotation).
EIF2AK2	transfac_pro__M04887	TCF12 (directAnnotation).
EIF2AK2	tfdimers__MD00026	IRF1; MYB (directAnnotation).
EIF2AK2	transfac_pro__M05636	ZNF134; ZNF154; ZNF256; ZNF304; ZNF418; ZNF419; ZNF480; ZNF548; ZNF549; ZNF552; ZNF561; ZNF562; ZNF584; ZNF586; ZNF587B; ZNF610; ZNF772; ZNF773; ZNF792; ZNF793; ZNF837 (inferredBy_Orthology).
EIF2AK2	metacluster_22.33	MAFK (inferredBy_Orthology).
EIF2AK2	transfac_pro__M05749	ZNF470 (directAnnotation).
EIF2AK2	metacluster_103.2	ZNF136; ZNF680 (directAnnotation).
EIF2AK2	metacluster_22.28	BACH1 (directAnnotation).
EIF2AK2	transfac_pro__M06826	ZNF516 (inferredBy_Orthology).
EIF2AK2	transfac_pro__M05513	ZNF641 (inferredBy_Orthology).
EIF2AK2	transfac_pro__M05352	ZNF692 (inferredBy_Orthology).
EIF2AK2	taipale_tf_pairs__TEAD4_ELK3_NCCGGAANNNNNNNMATWCC_CAP_repr	ELK3; TEAD4 (directAnnotation).
EIF2AK2	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
EIF2AK2	transfac_pro__M06055	ZNF99 (directAnnotation).
EIF2AK2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
EIF2AK2	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
EIF2AK2	kznf__ZNF302_Imbeault2017_OM_RCADE	ZNF302 (directAnnotation).
EIF2AK2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
EIF2AK2	transfac_pro__M06604	ZNF524 (directAnnotation).
EIF2AK2	transfac_pro__M06839	ZNF263 (inferredBy_Orthology).
EIF2AK2	transfac_pro__M06249	ZNF616 (directAnnotation).
EIF2AK2	tfdimers__MD00554	CUX1; EP300 (directAnnotation).
EIF2AK2	transfac_pro__M07329	SP7 (directAnnotation).
EIF2AK2	transfac_pro__M01837	KLF11 (directAnnotation).
EIF2AK2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
EIF2AK2	swissregulon__hs__KLF6	KLF6 (directAnnotation).
EIF2AK2	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
EIF2AK2	metacluster_163.2	ZNF682 (directAnnotation).
EIF2AK2	transfac_pro__M00938	E2F1 (directAnnotation).
EIF2AK2	metacluster_23.5	WT1 (directAnnotation).
EIF2AK2	swissregulon__mm__Elf3	ELF3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
EIF2AK2	"Fostamatinib"	DB12010	small molecule
EIF2AK2	"H-89"	DB07995	small molecule
EIF2AK2	"Indomethacin"	DB00328	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."