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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: DPYD

Summary for DPYD

Gene information	Gene symbol	DPYD
	Ensembl ID	ENSG00000188641
	Entrez ID	1806
	Gene name	dihydropyrimidine dehydrogenase
	Synonyms	DHPDHase\|DPD
	Gene type	protein_coding
	UniProtAcc	Q12882

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Dataset with differentially expressed gene: DPYD

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.558474	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.431424	4.34e-07
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.286898	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.278531	1.19e-30

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Expression of DPYD in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DPYD

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DPYD

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DPYD	hsa-miR-4775	99.0384	NM_000110
DPYD	hsa-miR-5680	98.0192	NM_000110
DPYD	hsa-miR-8485	96.5063	NM_001160301
DPYD	hsa-miR-4790-3p	96.3623	NM_000110
DPYD	hsa-miR-4310	94.6251	NM_000110
DPYD	hsa-miR-7110-3p	93.8992	NM_001160301
DPYD	hsa-miR-6732-3p	93.3422	NM_001160301
DPYD	hsa-miR-6873-3p	93.17	NM_001160301
DPYD	hsa-miR-3064-3p	92.7434	NM_000110
DPYD	hsa-miR-7157-5p	92.5425	NM_000110
DPYD	hsa-miR-3978	91.8997	NM_000110
DPYD	hsa-miR-551b-5p	91.3314	NM_000110
DPYD	hsa-miR-548m	90.5113	NM_000110
DPYD	hsa-miR-335-3p	90.4161	NM_000110
DPYD	hsa-miR-590-3p	89.2045	NM_000110
DPYD	hsa-miR-1277-5p	89.028	NM_000110
DPYD	hsa-miR-578	88.2373	NM_000110
DPYD	hsa-miR-567	87.9237	NM_000110
DPYD	hsa-miR-3145-3p	86.4317	NM_000110
DPYD	hsa-miR-96-5p	86.2225	NM_000110
DPYD	hsa-miR-494-3p	86.1708	NM_000110
DPYD	hsa-miR-3646	86.0966	NM_001160301
DPYD	hsa-miR-611	85.6829	NM_001160301
DPYD	hsa-miR-3131	85.6829	NM_001160301
DPYD	hsa-miR-3688-5p	85.3021	NM_000110
DPYD	hsa-miR-302f	84.0228	NM_000110
DPYD	hsa-miR-1271-5p	83.8606	NM_000110
DPYD	hsa-miR-12133	83.8606	NM_000110
DPYD	hsa-miR-605-5p	83.407	NM_001160301
DPYD	hsa-miR-548at-5p	83.3107	NM_000110
DPYD	hsa-miR-372-5p	82.9746	NM_001160301
DPYD	hsa-miR-1279	81.5232	NM_000110
DPYD	hsa-miR-5696	81.281	NM_001160301

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Motifs and transcription factors (TFs) regulating DPYD

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DPYD	metacluster_175.1	ZNF283 (directAnnotation).
DPYD	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
DPYD	hdpi__FEZF2	FEZF2 (directAnnotation).
DPYD	cisbp__M00343	PAX6 (directAnnotation).
DPYD	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DPYD	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
DPYD	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
DPYD	transfac_pro__M12694	ZFP14 (directAnnotation).
DPYD	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DPYD	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
DPYD	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DPYD	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
DPYD	cisbp__M00341	PAX6 (directAnnotation).
DPYD	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
DPYD	swissregulon__hs__CHD1	CHD1 (directAnnotation).
DPYD	swissregulon__hs__KLF6	KLF6 (directAnnotation).
DPYD	transfac_pro__M02898	SMAD3 (directAnnotation).
DPYD	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DPYD	transfac_pro__M07387	ZBTB7A (directAnnotation).
DPYD	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
DPYD	transfac_pro__M00430	E2F1 (directAnnotation).
DPYD	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DPYD	jaspar__MA1122.1	TFDP1 (directAnnotation).
DPYD	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
DPYD	metacluster_198.3	ZFP64 (directAnnotation).
DPYD	jaspar__MA1721.1	ZNF93 (directAnnotation).
DPYD	transfac_pro__M08005	TCFL5 (inferredBy_Orthology).
DPYD	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
DPYD	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DPYD	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
DPYD	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
DPYD	transfac_pro__M03876	ZBTB33 (directAnnotation).
DPYD	transfac_pro__M04646	FOXN4 (directAnnotation).
DPYD	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
DPYD	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
DPYD	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
DPYD	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DPYD	transfac_pro__M07329	SP7 (directAnnotation).
DPYD	transfac_pro__M04617	ZBTB7A (directAnnotation).
DPYD	transfac_pro__M07436	WT1 (directAnnotation).
DPYD	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
DPYD	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
DPYD	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
DPYD	metacluster_155.11	SPZ1 (directAnnotation).
DPYD	transfac_pro__M04877	GTF3C2 (directAnnotation).
DPYD	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
DPYD	transfac_public__M00072	TFCP2 (directAnnotation).
DPYD	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DPYD	cisbp__M01733	CCDC169-SOHLH2; SOHLH2 (inferredBy_Orthology).
DPYD	transfac_pro__M12634	ZBTB17 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
DPYD	"(5S)-5-Iododihydro-2,4(1H,3H)-pyrimidinedione"	DB02303	small molecule
DPYD	"5-Iodouracil"	DB03554	small molecule
DPYD	"6-Carboxymethyluracil"	DB03048	small molecule
DPYD	"Eniluracil"	DB03516	small molecule
DPYD	"Flavin adenine dinucleotide"	DB03147	small molecule
DPYD	"Flavin mononucleotide"	DB03247	small molecule
DPYD	"Gimeracil"	DB09257	small molecule
DPYD	"NADPH"	DB02338	small molecule
DPYD	"Tegafur-uracil"	DB09327	small molecule
DPYD	"Uracil"	DB03419	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."