Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DNAJB14

Summary for DNAJB14

Gene information	Gene symbol	DNAJB14
	Ensembl ID	ENSG00000164031
	Entrez ID	79982
	Gene name	DnaJ heat shock protein family (Hsp40) member B14
	Synonyms	FLJ14281
	Gene type	protein_coding
	UniProtAcc	Q8TBM8

Top

Dataset with differentially expressed gene: DNAJB14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.26382	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.253949	1.40e-19
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.29869	0.00e+00

Top

Expression of DNAJB14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to DNAJB14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating DNAJB14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DNAJB14	hsa-miR-5696	99.6281	NM_001278310
DNAJB14	hsa-miR-5011-5p	99.2267	NM_001278310
DNAJB14	hsa-miR-559	98.0532	NM_001031723
DNAJB14	hsa-miR-548am-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548c-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548y	97.1199	NM_001031723
DNAJB14	hsa-miR-548ap-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548ak	97.1199	NM_001031723
DNAJB14	hsa-miR-548o-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548ad-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548w	97.1199	NM_001031723
DNAJB14	hsa-miR-548as-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548ay-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548ar-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548d-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548ab	97.1199	NM_001031723
DNAJB14	hsa-miR-548b-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548h-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548bb-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548j-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548au-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548ae-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548a-5p	97.1199	NM_001031723
DNAJB14	hsa-miR-548i	97.1199	NM_001031723
DNAJB14	hsa-miR-190a-3p	96.9946	NM_001278310
DNAJB14	hsa-miR-30d-3p	96.741	NM_001031723
DNAJB14	hsa-miR-30a-3p	96.741	NM_001031723
DNAJB14	hsa-miR-30e-3p	96.741	NM_001031723
DNAJB14	hsa-miR-548aq-5p	96.6417	NM_001031723
DNAJB14	hsa-miR-1277-5p	96.4738	NM_001278310
DNAJB14	hsa-miR-4760-3p	94.5847	NM_001278310
DNAJB14	hsa-miR-4668-5p	94.5103	NM_001278310
DNAJB14	hsa-miR-5582-3p	93.9787	NM_001278310
DNAJB14	hsa-miR-579-3p	93.5259	NM_001278310
DNAJB14	hsa-miR-664b-3p	92.7298	NM_001278310
DNAJB14	hsa-miR-548m	92.0882	NM_001278310
DNAJB14	hsa-miR-5584-5p	91.7974	NM_001278310
DNAJB14	hsa-miR-4282	90.8518	NM_001278310
DNAJB14	hsa-miR-548c-3p	90.0527	NM_001278310
DNAJB14	hsa-miR-3148	88.9315	NM_001278310
DNAJB14	hsa-miR-586	88.1017	NM_001031723
DNAJB14	hsa-miR-3065-5p	87.818	NM_001031723
DNAJB14	hsa-miR-4729	87.21	NM_001031723
DNAJB14	hsa-miR-4494	86.9117	NM_001031723
DNAJB14	hsa-miR-500a-5p	86.8524	NM_001031723
DNAJB14	hsa-miR-548av-3p	86.6016	NM_001278310
DNAJB14	hsa-miR-105-5p	86.5023	NM_001031723
DNAJB14	hsa-miR-7853-5p	86.5023	NM_001031723
DNAJB14	hsa-miR-551b-5p	86.3981	NM_001278310
DNAJB14	hsa-miR-633	85.1014	NM_001278310

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating DNAJB14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DNAJB14	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
DNAJB14	transfac_public__M00491	PATZ1 (directAnnotation).
DNAJB14	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
DNAJB14	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
DNAJB14	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
DNAJB14	transfac_pro__M02089	E2F3 (directAnnotation).
DNAJB14	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
DNAJB14	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
DNAJB14	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
DNAJB14	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."