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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DNAJB1

Summary for DNAJB1

Gene information	Gene symbol	DNAJB1
	Ensembl ID	ENSG00000132002
	Entrez ID	3337
	Gene name	DnaJ heat shock protein family (Hsp40) member B1
	Synonyms	Hsp40\|HSPF1\|RSPH16B\|Sis1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DNAJB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.778047	1.20e-05
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.317404	2.11e-10
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.250381	6.88e-39
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	1.02494	3.48e-35
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.442888	3.17e-23
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	0.653317	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.65355	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.346093	2.05e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.287813	3.45e-27
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.494507	4.20e-02
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	1.38838	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.738364	5.98e-25
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.586577	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	-0.369622	1.42e-14
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	pDCs	-0.417157	4.69e-02
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	-0.677385	2.52e-33
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	B cells	-1.17022	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.311929	2.09e-22
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	-0.54333	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	-0.641847	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-1.64456	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-2.46737	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.353141	5.68e-37
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.74556	1.66e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	-0.675977	3.74e-14
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.517583	8.35e-08
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.509405	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.26387	1.71e-12
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.554121	5.69e-09
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.331698	3.59e-05
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD4+ T cells	-0.716424	4.04e-02
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD8+ T cells	-0.305002	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.432544	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.316373	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.330339	2.95e-11
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.35798	3.19e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	0.339587	2.11e-06
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	CD8+ T cells	-0.293937	2.61e-40
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.452609	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	CD4+ T cells	-0.304789	1.27e-04
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	NK cells	-0.378847	2.41e-39
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	CD8+ T cells	-0.283864	1.46e-22
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.695724	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.286144	0.00e+00

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Expression of DNAJB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DNAJB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DNAJB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DNAJB1	hsa-miR-377-3p	95.6014	NM_001300914
DNAJB1	hsa-miR-548h-3p	95.1764	NM_001300914
DNAJB1	hsa-miR-548d-3p	95.1764	NM_001300914
DNAJB1	hsa-miR-548bb-3p	95.1764	NM_001300914
DNAJB1	hsa-miR-548z	95.1764	NM_001300914
DNAJB1	hsa-miR-548ac	95.1764	NM_001300914
DNAJB1	hsa-miR-4802-3p	93.2777	NM_001300914
DNAJB1	hsa-miR-19a-3p	91.6805	NM_001300914
DNAJB1	hsa-miR-19b-3p	91.6805	NM_001300914
DNAJB1	hsa-miR-518c-5p	91.0001	NM_001300914
DNAJB1	hsa-miR-1205	90.0235	NM_001300914
DNAJB1	hsa-miR-10394-5p	90.0235	NM_001300914
DNAJB1	hsa-miR-7114-3p	89.463	NM_001300914
DNAJB1	hsa-miR-1180-5p	89.15	NM_001300914
DNAJB1	hsa-miR-497-3p	88.5155	NM_001300914
DNAJB1	hsa-miR-5681b	88.1011	NM_001300914
DNAJB1	hsa-miR-6843-3p	86.6855	NM_001300914
DNAJB1	hsa-miR-6848-3p	86.6855	NM_001300914
DNAJB1	hsa-miR-597-3p	85.7625	NM_001300914
DNAJB1	hsa-miR-665	85.2324	NM_001300914
DNAJB1	hsa-miR-155-5p	83.9573	NM_001300914
DNAJB1	hsa-miR-875-3p	82.6378	NM_001300914
DNAJB1	hsa-miR-6832-3p	81.9696	NM_001300914
DNAJB1	hsa-miR-6731-5p	80.8509	NM_001300914
DNAJB1	hsa-miR-8085	80.8509	NM_001300914

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Motifs and transcription factors (TFs) regulating DNAJB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DNAJB1	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
DNAJB1	metacluster_141.4	GLIS2 (directAnnotation).
DNAJB1	metacluster_182.10	ZFX (directAnnotation).
DNAJB1	taipale_tf_pairs__ELK1_EVX1_RSCGGWANNNNYMATTA_CAP_repr	ELK1; EVX1 (directAnnotation).
DNAJB1	tfdimers__MD00297	POU5F1; ZEB1 (directAnnotation).
DNAJB1	transfac_pro__M05698	ZNF141 (directAnnotation).
DNAJB1	metacluster_172.29	ZNF131 (directAnnotation). ZNF131 (inferredBy_Orthology).
DNAJB1	taipale_tf_pairs__FLI1_DLX2_RSCGGAARYAATTA_CAP	DLX2; FLI1 (directAnnotation).
DNAJB1	metacluster_139.9	TFE3 (inferredBy_Orthology).
DNAJB1	transfac_pro__M05519	FEZF2 (inferredBy_Orthology).
DNAJB1	transfac_pro__M06141	ZNF708 (directAnnotation).
DNAJB1	transfac_pro__M05890	ZNF274 (directAnnotation).
DNAJB1	transfac_pro__M06455	ZNF695 (directAnnotation).
DNAJB1	transfac_pro__M05298	OVOL3 (directAnnotation).
DNAJB1	tfdimers__MD00410	HMGA1; HMGA2; KLF4 (directAnnotation).
DNAJB1	transfac_pro__M06249	ZNF616 (directAnnotation).
DNAJB1	transfac_pro__M06326	ZNF841 (directAnnotation).
DNAJB1	jaspar__MA0502.2	NFYB (directAnnotation).
DNAJB1	transfac_pro__M05427	ZNF516 (directAnnotation).
DNAJB1	transfac_pro__M06071	ZNF814 (directAnnotation).
DNAJB1	transfac_pro__M04746	E2F1 (directAnnotation).
DNAJB1	transfac_pro__M05672	ZNF133 (directAnnotation).
DNAJB1	metacluster_86.5	ZNF324; ZNF418 (directAnnotation).
DNAJB1	tfdimers__MD00210	CDX2; HMBOX1 (directAnnotation).
DNAJB1	metacluster_63.4	ZNF672 (directAnnotation).
DNAJB1	metacluster_92.4	ZNF33B (directAnnotation).
DNAJB1	transfac_pro__M04933	STAT3 (directAnnotation).
DNAJB1	metacluster_102.2	ZBED1 (directAnnotation).
DNAJB1	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
DNAJB1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
DNAJB1	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
DNAJB1	transfac_pro__M06259	ZNF91 (directAnnotation).
DNAJB1	hocomoco__HSF1_HUMAN.H11MO.1.A	HSF1 (directAnnotation).
DNAJB1	transfac_pro__M06834	PEG3 (directAnnotation).
DNAJB1	transfac_pro__M00742	FOXJ1 (directAnnotation).
DNAJB1	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
DNAJB1	taipale_tf_pairs__GCM1_ELK1_RKRNRGGCGGAARCGGAAGNN_CAP_repr	ELK1; GCM1 (directAnnotation).
DNAJB1	transfac_pro__M06872	ZNF671 (directAnnotation).
DNAJB1	transfac_pro__M06242	ZNF266 (directAnnotation).
DNAJB1	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
DNAJB1	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
DNAJB1	metacluster_160.25	ZNF732 (directAnnotation).
DNAJB1	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
DNAJB1	hdpi__ARNTL	ARNTL (directAnnotation).
DNAJB1	dbtfbs__ZBTB26_HepG2_ENCSR184SVO_merged_N1	ZBTB26 (directAnnotation).
DNAJB1	transfac_pro__M05838	ZNF550 (directAnnotation).
DNAJB1	transfac_pro__M00631	NR1H4; RXRA (directAnnotation).
DNAJB1	jaspar__MA1939.1	SREBF2 (directAnnotation).
DNAJB1	taipale_tf_pairs__HOXB2_PITX1_TAATKRNNNNGGATTA_CAP_repr	HOXB2; PITX1 (directAnnotation).
DNAJB1	transfac_pro__M06913	ZNF256 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."