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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DMXL2

Summary for DMXL2

Gene information	Gene symbol	DMXL2
	Ensembl ID	ENSG00000104093
	Entrez ID	23312
	Gene name	Dmx like 2
	Synonyms	DFNA71\|KIAA0856\|RC3
	Gene type	protein_coding
	UniProtAcc	Q8TDJ6

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Dataset with differentially expressed gene: DMXL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.371221	3.26e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.383014	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.256542	1.28e-26
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.301329	2.62e-33
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.278208	3.65e-41
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.513439	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.261999	6.99e-18

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Expression of DMXL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DMXL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DMXL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DMXL2	hsa-miR-543	99.4852	NM_001174116
DMXL2	hsa-miR-4262	99.2049	NM_001174116
DMXL2	hsa-miR-181a-5p	98.9158	NM_001174116
DMXL2	hsa-miR-181d-5p	98.9158	NM_001174116
DMXL2	hsa-miR-181b-5p	98.9158	NM_001174116
DMXL2	hsa-miR-181c-5p	98.9158	NM_001174116
DMXL2	hsa-miR-216a-5p	98.7519	NM_015263
DMXL2	hsa-miR-3619-5p	97.3545	NM_001174116
DMXL2	hsa-miR-214-3p	97.3163	NM_001174116
DMXL2	hsa-miR-761	97.3163	NM_001174116
DMXL2	hsa-miR-3919	94.7909	NM_001174116
DMXL2	hsa-miR-922	94.5849	NM_001174116
DMXL2	hsa-miR-193b-3p	93.8829	NM_001174116
DMXL2	hsa-miR-193a-3p	93.8829	NM_001174116
DMXL2	hsa-miR-499b-3p	93.6497	NM_001174116
DMXL2	hsa-miR-499a-3p	93.6497	NM_001174116
DMXL2	hsa-miR-19a-3p	93.3459	NM_001174116
DMXL2	hsa-miR-19b-3p	93.3459	NM_001174116
DMXL2	hsa-miR-618	93.0303	NM_015263
DMXL2	hsa-miR-605-3p	92.9283	NM_001174116
DMXL2	hsa-miR-205-5p	92.8943	NM_001174116
DMXL2	hsa-miR-3121-3p	92.7065	NM_001174116
DMXL2	hsa-miR-7-2-3p	92.6649	NM_001174116
DMXL2	hsa-miR-7-1-3p	92.6649	NM_001174116
DMXL2	hsa-miR-7703	92.351	NM_015263
DMXL2	hsa-miR-6126	90.39	NM_001174116
DMXL2	hsa-miR-153-3p	89.776	NM_001174116
DMXL2	hsa-miR-3688-5p	89.6355	NM_015263
DMXL2	hsa-miR-5187-3p	89.424	NM_001174116
DMXL2	hsa-miR-1283	89.2537	NM_001174116
DMXL2	hsa-miR-10527-5p	87.6328	NM_001174116
DMXL2	hsa-miR-133a-5p	87.0613	NM_015263
DMXL2	hsa-miR-133a-3p	86.9168	NM_001174116
DMXL2	hsa-miR-133b	86.9168	NM_001174116
DMXL2	hsa-miR-664a-3p	86.7842	NM_001174116
DMXL2	hsa-miR-3190-5p	85.8312	NM_001174116
DMXL2	hsa-miR-6875-3p	85.5477	NM_015263
DMXL2	hsa-miR-1537-5p	85.4714	NM_015263
DMXL2	hsa-miR-4699-3p	85.1713	NM_015263
DMXL2	hsa-miR-30a-5p	84.0982	NM_001174116
DMXL2	hsa-miR-30e-5p	84.0982	NM_001174116
DMXL2	hsa-miR-30b-5p	84.0982	NM_001174116
DMXL2	hsa-miR-30d-5p	84.0982	NM_001174116
DMXL2	hsa-miR-30c-5p	84.0982	NM_001174116
DMXL2	hsa-miR-4291	84.0613	NM_001174116
DMXL2	hsa-miR-512-5p	83.484	NM_015263
DMXL2	hsa-miR-4661-5p	82.8564	NM_015263
DMXL2	hsa-miR-4666a-3p	82.6394	NM_015263
DMXL2	hsa-miR-101-3p	81.9931	NM_001174116
DMXL2	hsa-miR-3143	81.9531	NM_015263

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Motifs and transcription factors (TFs) regulating DMXL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DMXL2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DMXL2	transfac_pro__M04916	TAF1 (directAnnotation).
DMXL2	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
DMXL2	transfac_pro__M01973	PLAG1 (directAnnotation).
DMXL2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
DMXL2	tfdimers__MD00483	ZBTB14 (directAnnotation).
DMXL2	metacluster_198.3	ZFP64 (directAnnotation).
DMXL2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
DMXL2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DMXL2	transfac_pro__M01303	SP1 (directAnnotation).
DMXL2	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
DMXL2	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
DMXL2	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
DMXL2	transfac_pro__M07387	ZBTB7A (directAnnotation).
DMXL2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
DMXL2	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
DMXL2	metacluster_144.13	HIC1; HIC1 (directAnnotation).
DMXL2	transfac_pro__M00665	SP3 (directAnnotation).
DMXL2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DMXL2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DMXL2	transfac_pro__M02898	SMAD3 (directAnnotation).
DMXL2	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
DMXL2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
DMXL2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
DMXL2	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
DMXL2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DMXL2	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
DMXL2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
DMXL2	transfac_pro__M07329	SP7 (directAnnotation).
DMXL2	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
DMXL2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DMXL2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
DMXL2	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
DMXL2	jaspar__MA0079.5	SP1 (directAnnotation).
DMXL2	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
DMXL2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
DMXL2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
DMXL2	cisbp__M07938	E2F1 (directAnnotation).
DMXL2	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
DMXL2	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNGGCGCSNNNNCRMN_CAP	E2F3; TBX21 (directAnnotation).
DMXL2	taipale_tf_pairs__CUX1_TBX21_NTCACACMNNNATCRATN_CAP_repr	CUX1; TBX21 (directAnnotation).
DMXL2	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
DMXL2	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
DMXL2	metacluster_135.3	ZNF486 (directAnnotation).
DMXL2	taipale_tf_pairs__E2F3_EOMES_NNGYGNNNNGGCGCSNNNNCRCNN_CAP_repr	E2F3; EOMES (directAnnotation).
DMXL2	transfac_pro__M05387	ZNF653 (inferredBy_Orthology).
DMXL2	metacluster_168.11	ZNF771; ZNF771 (directAnnotation).
DMXL2	jaspar__MA0131.2	HINFP (directAnnotation).
DMXL2	cisbp__M00341	PAX6 (directAnnotation).
DMXL2	transfac_pro__M00652	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."