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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DEK

Summary for DEK

Gene information	Gene symbol	DEK
	Ensembl ID	ENSG00000124795
	Entrez ID	7913
	Gene name	DEK proto-oncogene
	Synonyms	D6S231E
	Gene type	protein_coding
	UniProtAcc	P35659

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Dataset with differentially expressed gene: DEK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.293191	2.33e-30
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.603795	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.258338	3.24e-14
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.499043	5.91e-21
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.411601	6.70e-11
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	0.253789	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.512834	3.10e-22
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.595224	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	0.283581	7.22e-20
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.4243	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.478699	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.274035	2.72e-09
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.31709	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.750236	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.58669	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.475532	3.63e-07
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.303073	6.93e-23
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.337671	6.35e-16
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.479306	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.564765	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.261777	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.589206	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.706354	0.00e+00

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Expression of DEK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DEK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DEK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DEK	hsa-miR-141-3p	98.4827	NM_001134709
DEK	hsa-miR-200a-3p	98.4827	NM_001134709
DEK	hsa-miR-4722-5p	95.7938	NM_001134709
DEK	hsa-miR-4774-5p	95.7216	NM_001134709
DEK	hsa-miR-548n	95.2772	NM_001134709
DEK	hsa-miR-133a-5p	94.6373	NM_001134709
DEK	hsa-miR-5100	93.0035	NM_001134709
DEK	hsa-miR-4762-5p	92.3949	NM_001134709
DEK	hsa-miR-7-2-3p	91.9019	NM_001134709
DEK	hsa-miR-7-1-3p	91.9019	NM_001134709
DEK	hsa-miR-4272	91.3759	NM_001134709
DEK	hsa-miR-190a-3p	90.8068	NM_001134709
DEK	hsa-miR-628-5p	90.4992	NM_001134709
DEK	hsa-miR-9718	90.4992	NM_001134709
DEK	hsa-miR-138-5p	90.0786	NM_001134709
DEK	hsa-miR-6131	90.0786	NM_001134709
DEK	hsa-miR-8084	89.5459	NM_001134709
DEK	hsa-miR-6773-3p	87.9469	NM_001134709
DEK	hsa-miR-127-5p	87.7747	NM_001134709
DEK	hsa-miR-4804-3p	87.0649	NM_001134709
DEK	hsa-miR-1322	87.0362	NM_001134709
DEK	hsa-miR-223-5p	86.9439	NM_001134709
DEK	hsa-miR-4659b-5p	86.5176	NM_001134709
DEK	hsa-miR-548e-5p	86.3691	NM_001134709
DEK	hsa-miR-4659a-5p	86.1769	NM_001134709
DEK	hsa-miR-6719-3p	86.0691	NM_001134709
DEK	hsa-miR-425-5p	85.6387	NM_001134709
DEK	hsa-miR-181b-5p	85.2629	NM_001134709
DEK	hsa-miR-4262	85.2629	NM_001134709
DEK	hsa-miR-3163	84.2371	NM_001134709
DEK	hsa-miR-3660	84.1462	NM_001134709
DEK	hsa-miR-4526	84.1462	NM_001134709
DEK	hsa-miR-4698	84.0329	NM_001134709
DEK	hsa-miR-513a-3p	83.6543	NM_001134709
DEK	hsa-miR-513c-3p	83.6543	NM_001134709
DEK	hsa-miR-1286	83.2183	NM_001134709
DEK	hsa-miR-4643	82.86	NM_001134709
DEK	hsa-miR-26b-3p	81.7895	NM_001134709
DEK	hsa-miR-4760-5p	81.7553	NM_001134709
DEK	hsa-miR-181d-5p	81.5259	NM_001134709
DEK	hsa-miR-181c-5p	81.5259	NM_001134709
DEK	hsa-miR-181a-5p	81.5259	NM_001134709
DEK	hsa-miR-4652-3p	81.4752	NM_001134709
DEK	hsa-miR-6500-3p	80.8384	NM_001134709
DEK	hsa-miR-4696	80.1787	NM_001134709

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Motifs and transcription factors (TFs) regulating DEK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DEK	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
DEK	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
DEK	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
DEK	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
DEK	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
DEK	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
DEK	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
DEK	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
DEK	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DEK	cisbp__M08198	ELF1 (directAnnotation).
DEK	transfac_pro__M00652	NRF1 (directAnnotation).
DEK	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
DEK	transfac_pro__M04866	HDAC2 (directAnnotation).
DEK	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
DEK	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
DEK	transfac_pro__M05574	ZFP92 (directAnnotation).
DEK	transfac_pro__M04944	GABPA (directAnnotation).
DEK	transfac_pro__M01182	HINFP (directAnnotation).
DEK	hdpi__FLI1	FLI1 (directAnnotation).
DEK	cisbp__M02645	ETS1 (directAnnotation).
DEK	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
DEK	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
DEK	metacluster_141.2	E2F2; E2F3 (directAnnotation).
DEK	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
DEK	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
DEK	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
DEK	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
DEK	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DEK	hdpi__TIMELESS	TIMELESS (directAnnotation).
DEK	taipale_tf_pairs__E2F1_EOMES_RGGTGTNNNGGCGSNNTNNCRSNN_CAP	E2F1; EOMES (directAnnotation).
DEK	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
DEK	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
DEK	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
DEK	transfac_pro__M06042	ZNF208 (directAnnotation).
DEK	transfac_pro__M06404	ZNF497 (directAnnotation).
DEK	jaspar__MA0502.2	NFYB (directAnnotation).
DEK	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
DEK	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
DEK	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
DEK	kznf__ZSCAN29_TF_Evolution_PBM	ZSCAN29 (directAnnotation).
DEK	taipale_tf_pairs__FOXJ3_ELF1_NNARAAAACCGAAWMN_CAP	ELF1; FOXJ3 (directAnnotation).
DEK	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
DEK	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
DEK	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
DEK	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
DEK	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
DEK	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
DEK	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
DEK	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
DEK	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."