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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DCUN1D5

Summary for DCUN1D5

Gene information	Gene symbol	DCUN1D5
	Ensembl ID	ENSG00000137692
	Entrez ID	84259
	Gene name	defective in cullin neddylation 1 domain containing 5
	Synonyms	FLJ32431\|MGC2714
	Gene type	protein_coding
	UniProtAcc	Q9BTE7

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Dataset with differentially expressed gene: DCUN1D5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.464352	9.48e-35
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.549445	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.297939	5.59e-21
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.914072	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.297151	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.682783	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.603812	8.31e-42
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.720066	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.567199	6.94e-40
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.288918	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.347192	4.49e-39
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.479713	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.464147	0.00e+00

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Expression of DCUN1D5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DCUN1D5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DCUN1D5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DCUN1D5	hsa-miR-651-3p	99.5623	NM_001318741
DCUN1D5	hsa-miR-7110-3p	99.078	NM_001318739
DCUN1D5	hsa-miR-5696	97.4397	NM_001318741
DCUN1D5	hsa-miR-6830-3p	97.389	NM_001318739
DCUN1D5	hsa-miR-5582-3p	97.3714	NM_001318741
DCUN1D5	hsa-miR-4729	96.9623	NM_001318741
DCUN1D5	hsa-miR-16-2-3p	96.5611	NM_001318741
DCUN1D5	hsa-miR-195-3p	96.5611	NM_001318741
DCUN1D5	hsa-miR-3148	96.4713	NM_001318739
DCUN1D5	hsa-miR-513a-3p	95.5409	NM_001318739
DCUN1D5	hsa-miR-513c-3p	95.5409	NM_001318739
DCUN1D5	hsa-miR-3606-3p	95.2253	NM_001318739
DCUN1D5	hsa-miR-1250-3p	95.0114	NM_001318741
DCUN1D5	hsa-miR-892c-5p	94.69	NM_001318739
DCUN1D5	hsa-miR-3617-3p	94.5395	NM_001318739
DCUN1D5	hsa-miR-3658	94.4747	NM_001318741
DCUN1D5	hsa-miR-4717-3p	94.1203	NM_001318739
DCUN1D5	hsa-miR-5187-3p	94.0542	NM_001318741
DCUN1D5	hsa-miR-506-5p	93.6936	NM_001318739
DCUN1D5	hsa-miR-622	93.4617	NM_001318739
DCUN1D5	hsa-miR-6074	93.3667	NM_001318741
DCUN1D5	hsa-miR-3613-3p	92.8349	NM_001318739
DCUN1D5	hsa-miR-4803	92.6351	NM_001318741
DCUN1D5	hsa-miR-4477b	92.0879	NM_001318741
DCUN1D5	hsa-miR-4482-3p	91.8281	NM_001318741
DCUN1D5	hsa-miR-590-3p	91.5009	NM_001318741
DCUN1D5	hsa-miR-545-3p	91.4551	NM_001318739
DCUN1D5	hsa-miR-664a-3p	91.2224	NM_001318741
DCUN1D5	hsa-miR-1264	91.1478	NM_001318739
DCUN1D5	hsa-miR-6883-3p	90.6152	NM_001318741
DCUN1D5	hsa-miR-641	90.4964	NM_001318741
DCUN1D5	hsa-miR-4318	90.2703	NM_001318741
DCUN1D5	hsa-miR-12123	90.231	NM_001318741
DCUN1D5	hsa-miR-548n	89.6961	NM_001318741
DCUN1D5	hsa-miR-3617-5p	89.4275	NM_001318741
DCUN1D5	hsa-miR-335-3p	89.419	NM_001318741
DCUN1D5	hsa-miR-5680	88.86	NM_001318741
DCUN1D5	hsa-miR-5007-3p	88.337	NM_001318741
DCUN1D5	hsa-miR-6809-3p	88.2701	NM_001318741
DCUN1D5	hsa-miR-6873-3p	88.1206	NM_001318741
DCUN1D5	hsa-miR-4719	87.8047	NM_001318739
DCUN1D5	hsa-miR-7856-5p	87.3686	NM_001318741
DCUN1D5	hsa-miR-6817-3p	87.0485	NM_001318739
DCUN1D5	hsa-miR-3680-3p	86.9358	NM_001318741
DCUN1D5	hsa-miR-371b-5p	86.0764	NM_001318741
DCUN1D5	hsa-miR-616-5p	86.0764	NM_001318741
DCUN1D5	hsa-miR-373-5p	86.0764	NM_001318741
DCUN1D5	hsa-miR-6874-3p	85.9526	NM_001318741
DCUN1D5	hsa-miR-148b-5p	85.9327	NM_001318741
DCUN1D5	hsa-miR-411-3p	85.7482	NM_001318739

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Motifs and transcription factors (TFs) regulating DCUN1D5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DCUN1D5	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
DCUN1D5	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
DCUN1D5	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
DCUN1D5	taipale_tf_pairs__ETV5_HOXA13_NNCGGAWGTNRTWAA_CAP	ETV5; HOXA13 (directAnnotation).
DCUN1D5	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
DCUN1D5	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
DCUN1D5	swissregulon__hs__ELF2	ELF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."