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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DCBLD2

Summary for DCBLD2

Gene information	Gene symbol	DCBLD2
	Ensembl ID	ENSG00000057019
	Entrez ID	131566
	Gene name	discoidin, CUB and LCCL domain containing 2
	Synonyms	CLCP1\|ESDN
	Gene type	protein_coding
	UniProtAcc	Q96PD2

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Dataset with differentially expressed gene: DCBLD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.899041	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.266985	3.67e-10
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.561335	1.55e-39
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-1.43114	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.352616	1.17e-16
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.288313	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.686606	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.302329	0.00e+00

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Expression of DCBLD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DCBLD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DCBLD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DCBLD2	hsa-miR-9-3p	99.6965	NM_080927
DCBLD2	hsa-miR-519b-3p	99.6653	NM_080927
DCBLD2	hsa-miR-519c-3p	99.6653	NM_080927
DCBLD2	hsa-miR-519a-3p	99.6653	NM_080927
DCBLD2	hsa-miR-548h-3p	99.2598	NM_080927
DCBLD2	hsa-miR-548ac	99.2598	NM_080927
DCBLD2	hsa-miR-548z	99.2598	NM_080927
DCBLD2	hsa-miR-548bb-3p	99.2598	NM_080927
DCBLD2	hsa-miR-548d-3p	99.2598	NM_080927
DCBLD2	hsa-miR-4426	98.6526	NM_080927
DCBLD2	hsa-miR-548x-3p	98.4515	NM_080927
DCBLD2	hsa-miR-548aj-3p	98.4515	NM_080927
DCBLD2	hsa-miR-101-3p	97.7838	NM_080927
DCBLD2	hsa-miR-548j-3p	97.6444	NM_080927
DCBLD2	hsa-miR-548ah-3p	97.6444	NM_080927
DCBLD2	hsa-miR-548am-3p	97.6444	NM_080927
DCBLD2	hsa-miR-548ae-3p	97.6444	NM_080927
DCBLD2	hsa-miR-548aq-3p	97.6444	NM_080927
DCBLD2	hsa-miR-4647	97.6328	NM_080927
DCBLD2	hsa-miR-4662b	97.6328	NM_080927
DCBLD2	hsa-miR-548c-3p	96.5298	NM_080927
DCBLD2	hsa-miR-548aa	95.2253	NM_080927
DCBLD2	hsa-miR-548ap-3p	95.2253	NM_080927
DCBLD2	hsa-miR-548t-3p	95.2253	NM_080927
DCBLD2	hsa-miR-498-5p	95.1123	NM_080927
DCBLD2	hsa-miR-4742-3p	94.8667	NM_080927
DCBLD2	hsa-miR-510-3p	94.5936	NM_080927
DCBLD2	hsa-miR-218-5p	94.3092	NM_080927
DCBLD2	hsa-miR-139-5p	94.0181	NM_080927
DCBLD2	hsa-miR-4262	93.8618	NM_080927
DCBLD2	hsa-miR-6124	93.5847	NM_080927
DCBLD2	hsa-miR-561-3p	93.3675	NM_080927
DCBLD2	hsa-miR-106a-5p	93.3351	NM_080927
DCBLD2	hsa-miR-106b-5p	93.3351	NM_080927
DCBLD2	hsa-miR-5190	93.3248	NM_080927
DCBLD2	hsa-miR-34c-3p	93.1535	NM_080927
DCBLD2	hsa-miR-4679	93.1015	NM_080927
DCBLD2	hsa-miR-542-3p	92.5758	NM_080927
DCBLD2	hsa-miR-130b-3p	92.5192	NM_080927
DCBLD2	hsa-miR-17-5p	92.3335	NM_080927
DCBLD2	hsa-miR-181a-5p	91.5616	NM_080927
DCBLD2	hsa-miR-181b-5p	91.5616	NM_080927
DCBLD2	hsa-miR-181d-5p	91.5616	NM_080927
DCBLD2	hsa-miR-181c-5p	91.5616	NM_080927
DCBLD2	hsa-miR-548e-5p	91.3599	NM_080927
DCBLD2	hsa-miR-4295	91.0922	NM_080927
DCBLD2	hsa-miR-301b-3p	91.0922	NM_080927
DCBLD2	hsa-miR-454-3p	91.0922	NM_080927
DCBLD2	hsa-miR-3666	91.0922	NM_080927
DCBLD2	hsa-miR-301a-3p	91.0922	NM_080927

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Motifs and transcription factors (TFs) regulating DCBLD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DCBLD2	transfac_pro__M05838	ZNF550 (directAnnotation).
DCBLD2	jaspar__MA1957.1	ELK1 (directAnnotation).
DCBLD2	transfac_pro__M06305	ZNF583 (inferredBy_Orthology).
DCBLD2	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
DCBLD2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
DCBLD2	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
DCBLD2	metacluster_23.5	WT1 (directAnnotation).
DCBLD2	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
DCBLD2	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
DCBLD2	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
DCBLD2	jaspar__MA1933.1	SREBF2 (directAnnotation).
DCBLD2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
DCBLD2	transfac_pro__M05711	ZNF37A (directAnnotation).
DCBLD2	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
DCBLD2	metacluster_112.5	HOXA4; PAX3; PAX7; PAX7 (directAnnotation).
DCBLD2	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_1	ELK1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."