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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DAP

Summary for DAP

Gene information	Gene symbol	DAP
	Ensembl ID	ENSG00000112977
	Entrez ID	1611
	Gene name	death associated protein
	Synonyms	DAP1
	Gene type	protein_coding
	UniProtAcc	P51397

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Dataset with differentially expressed gene: DAP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.86188	6.35e-08
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.330536	3.65e-08
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.271591	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.402905	7.01e-39
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.514543	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.252605	1.51e-07
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.701208	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.37295	2.87e-08
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.264145	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.336263	0.00e+00

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Expression of DAP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DAP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DAP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DAP	hsa-miR-6857-3p	92.2538	NM_001291963
DAP	hsa-miR-4722-5p	91.6612	NM_001291963
DAP	hsa-miR-4635	89.4026	NM_001291963
DAP	hsa-miR-149-5p	88.8567	NM_001291963
DAP	hsa-miR-7977	85.4259	NM_004394
DAP	hsa-miR-5093	85.1472	NM_004394
DAP	hsa-miR-3184-5p	84.2277	NM_001291963
DAP	hsa-miR-423-5p	84.2277	NM_001291963
DAP	hsa-miR-548k	84.2126	NM_001291963
DAP	hsa-miR-8054	84.2126	NM_001291963
DAP	hsa-miR-548av-5p	84.2126	NM_001291963
DAP	hsa-miR-6873-5p	83.8582	NM_004394
DAP	hsa-miR-5004-3p	80.406	NM_001291963

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Motifs and transcription factors (TFs) regulating DAP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DAP	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
DAP	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
DAP	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
DAP	metacluster_135.11	NR2C2 (directAnnotation).
DAP	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DAP	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DAP	cisbp__M00968	MTF2 (directAnnotation).
DAP	metacluster_198.3	ZFP64 (directAnnotation).
DAP	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DAP	cisbp__M00788	ZFY (inferredBy_Orthology).
DAP	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DAP	metacluster_175.1	ZNF283 (directAnnotation).
DAP	hdpi__ZNF304	ZNF304 (directAnnotation).
DAP	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DAP	transfac_pro__M01199	TRIM28 (directAnnotation).
DAP	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
DAP	metacluster_151.2	ZNF23 (directAnnotation).
DAP	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DAP	transfac_pro__M03806	ZBTB7C (directAnnotation).
DAP	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DAP	metacluster_141.2	E2F2; E2F3 (directAnnotation).
DAP	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
DAP	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
DAP	hdpi__TP73	TP73 (directAnnotation).
DAP	metacluster_81.7	CREB1 (directAnnotation).
DAP	tfdimers__MD00269	CRX; PBX1 (directAnnotation).
DAP	transfac_pro__M06181	ZNF165 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."