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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CYTH1

Summary for CYTH1

Gene information	Gene symbol	CYTH1
	Ensembl ID	ENSG00000108669
	Entrez ID	9267
	Gene name	cytohesin 1
	Synonyms	B2-1\|cytohesin-1\|D17S811E\|PSCD1
	Gene type	protein_coding
	UniProtAcc	Q15438

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Dataset with differentially expressed gene: CYTH1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.406069	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.300604	6.12e-07
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.425869	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.347432	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	B cells	-0.378209	7.06e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.730873	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.263153	8.68e-17
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.331014	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.261442	4.87e-13

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Expression of CYTH1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CYTH1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CYTH1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CYTH1	hsa-miR-532-3p	99.3356	NM_001292019
CYTH1	hsa-miR-3121-3p	93.7085	NM_001292018
CYTH1	hsa-miR-4713-5p	93.5114	NM_001292019
CYTH1	hsa-miR-1827	92.6276	NM_001292018
CYTH1	hsa-miR-495-3p	89.2404	NM_001292019
CYTH1	hsa-miR-5688	89.2404	NM_001292019
CYTH1	hsa-miR-4685-5p	89.1272	NM_001292018
CYTH1	hsa-miR-320c	88.3094	NM_001292018
CYTH1	hsa-miR-320d	88.3094	NM_001292018
CYTH1	hsa-miR-4429	88.3094	NM_001292018
CYTH1	hsa-miR-320b	88.3094	NM_001292018
CYTH1	hsa-miR-320a-3p	88.3094	NM_001292018
CYTH1	hsa-miR-6837-5p	87.644	NM_001292018
CYTH1	hsa-miR-1304-5p	87.2879	NM_001292019
CYTH1	hsa-miR-6815-3p	87.1602	NM_001292018
CYTH1	hsa-miR-429	85.8262	NM_001292018
CYTH1	hsa-miR-200b-3p	85.8262	NM_001292018
CYTH1	hsa-miR-200c-3p	85.8262	NM_001292018
CYTH1	hsa-miR-1236-3p	84.3274	NM_001292019
CYTH1	hsa-miR-7-1-3p	83.0893	NM_001292018
CYTH1	hsa-miR-7-2-3p	83.0893	NM_001292018
CYTH1	hsa-miR-5692a	80.0429	NM_001292018

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Motifs and transcription factors (TFs) regulating CYTH1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CYTH1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CYTH1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
CYTH1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CYTH1	transfac_pro__M07310	SP5 (directAnnotation).
CYTH1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
CYTH1	transfac_pro__M04817	ZBTB33 (directAnnotation).
CYTH1	transfac_pro__M12697	ZNF142 (directAnnotation).
CYTH1	metacluster_175.1	ZNF283 (directAnnotation).
CYTH1	tfdimers__MD00364	WT1 (directAnnotation).
CYTH1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CYTH1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
CYTH1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CYTH1	transfac_pro__M04916	TAF1 (directAnnotation).
CYTH1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
CYTH1	transfac_pro__M01973	PLAG1 (directAnnotation).
CYTH1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CYTH1	tfdimers__MD00483	ZBTB14 (directAnnotation).
CYTH1	metacluster_198.3	ZFP64 (directAnnotation).
CYTH1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CYTH1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CYTH1	transfac_pro__M01303	SP1 (directAnnotation).
CYTH1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
CYTH1	metacluster_143.13	ZBTB7A (directAnnotation).
CYTH1	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
CYTH1	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
CYTH1	transfac_pro__M07387	ZBTB7A (directAnnotation).
CYTH1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
CYTH1	metacluster_144.13	HIC1; HIC1 (directAnnotation).
CYTH1	transfac_pro__M00665	SP3 (directAnnotation).
CYTH1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CYTH1	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
CYTH1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
CYTH1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CYTH1	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
CYTH1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CYTH1	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
CYTH1	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
CYTH1	transfac_pro__M07329	SP7 (directAnnotation).
CYTH1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CYTH1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CYTH1	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
CYTH1	transfac_pro__M01122	ZNF219 (directAnnotation).
CYTH1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CYTH1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CYTH1	metacluster_84.2	RARA (directAnnotation).
CYTH1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CYTH1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CYTH1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CYTH1	jaspar__MA1122.1	TFDP1 (directAnnotation).
CYTH1	cisbp__M00341	PAX6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."