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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CUL3

Summary for CUL3

Gene information	Gene symbol	CUL3
	Ensembl ID	ENSG00000036257
	Entrez ID	8452
	Gene name	cullin 3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q13618

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Dataset with differentially expressed gene: CUL3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.251198	7.83e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.305294	9.95e-44
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.319342	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.325685	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.346877	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.258361	0.00e+00

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Expression of CUL3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CUL3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CUL3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CUL3	hsa-miR-3646	99.9556	NM_003590
CUL3	hsa-miR-5692a	99.2657	NM_001257197
CUL3	hsa-miR-576-5p	98.995	NM_001257197
CUL3	hsa-miR-4251	98.865	NM_001257197
CUL3	hsa-miR-455-3p	97.784	NM_001257197
CUL3	hsa-miR-4329	97.6758	NM_001257197
CUL3	hsa-miR-6719-3p	97.4571	NM_001257197
CUL3	hsa-miR-4776-3p	97.2456	NM_003590
CUL3	hsa-miR-570-3p	96.3296	NM_003590
CUL3	hsa-miR-545-3p	95.9551	NM_003590
CUL3	hsa-miR-548ar-3p	95.1702	NM_003590
CUL3	hsa-miR-95-5p	94.7029	NM_001257197
CUL3	hsa-miR-218-5p	94.3756	NM_001257197
CUL3	hsa-miR-548bc	93.7048	NM_003590
CUL3	hsa-miR-548a-3p	93.7048	NM_003590
CUL3	hsa-miR-548e-3p	93.7048	NM_003590
CUL3	hsa-miR-548f-3p	93.7048	NM_003590
CUL3	hsa-miR-548az-3p	93.7048	NM_003590
CUL3	hsa-miR-519c-3p	93.1525	NM_001257197
CUL3	hsa-miR-519b-3p	93.1525	NM_001257197
CUL3	hsa-miR-519a-3p	93.1525	NM_001257197
CUL3	hsa-miR-7152-5p	93.089	NM_003590
CUL3	hsa-miR-675-3p	92.9732	NM_003590
CUL3	hsa-miR-4695-3p	92.659	NM_003590
CUL3	hsa-miR-6501-3p	92.5838	NM_001257197
CUL3	hsa-miR-561-3p	92.5541	NM_003590
CUL3	hsa-miR-6508-5p	92.222	NM_001257197
CUL3	hsa-miR-4263	92.0281	NM_001257197
CUL3	hsa-miR-3120-3p	91.9839	NM_003590
CUL3	hsa-miR-580-5p	91.403	NM_003590
CUL3	hsa-miR-3618	91.2874	NM_001257197
CUL3	hsa-miR-5197-3p	90.8694	NM_003590
CUL3	hsa-miR-590-3p	90.7002	NM_003590
CUL3	hsa-miR-6809-3p	90.4527	NM_003590
CUL3	hsa-miR-8067	90.2116	NM_001257197
CUL3	hsa-miR-23b-3p	89.989	NM_001257197
CUL3	hsa-miR-23a-3p	89.989	NM_001257197
CUL3	hsa-miR-23c	89.989	NM_001257197
CUL3	hsa-miR-551b-5p	89.7436	NM_003590
CUL3	hsa-miR-513a-3p	89.1353	NM_001257197
CUL3	hsa-miR-513c-3p	89.1353	NM_001257197
CUL3	hsa-miR-6833-3p	89.0564	NM_003590
CUL3	hsa-miR-3126-3p	89.013	NM_003590
CUL3	hsa-miR-2110	88.9906	NM_003590
CUL3	hsa-miR-548g-3p	88.4732	NM_003590
CUL3	hsa-miR-3928-5p	88.277	NM_001257197
CUL3	hsa-miR-6806-3p	88.277	NM_001257197
CUL3	hsa-miR-4794	88.2677	NM_003590
CUL3	hsa-miR-510-3p	87.9518	NM_003590
CUL3	hsa-miR-6828-5p	87.7745	NM_001257197

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Motifs and transcription factors (TFs) regulating CUL3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CUL3	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
CUL3	cisbp__M00249	WT1 (directAnnotation).
CUL3	metacluster_182.10	ZFX (directAnnotation).
CUL3	hdpi__ZNF304	ZNF304 (directAnnotation).
CUL3	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
CUL3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CUL3	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CUL3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CUL3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CUL3	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
CUL3	metacluster_151.2	ZNF23 (directAnnotation).
CUL3	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CUL3	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
CUL3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CUL3	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
CUL3	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
CUL3	transfac_pro__M01253	CNOT3 (directAnnotation).
CUL3	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
CUL3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CUL3	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
CUL3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CUL3	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
CUL3	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
CUL3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CUL3	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
CUL3	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
CUL3	transfac_pro__M04817	ZBTB33 (directAnnotation).
CUL3	transfac_pro__M12697	ZNF142 (directAnnotation).
CUL3	metacluster_175.1	ZNF283 (directAnnotation).
CUL3	tfdimers__MD00364	WT1 (directAnnotation).
CUL3	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
CUL3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CUL3	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
CUL3	transfac_pro__M01973	PLAG1 (directAnnotation).
CUL3	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CUL3	tfdimers__MD00483	ZBTB14 (directAnnotation).
CUL3	metacluster_198.3	ZFP64 (directAnnotation).
CUL3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CUL3	transfac_pro__M01303	SP1 (directAnnotation).
CUL3	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
CUL3	metacluster_143.13	ZBTB7A (directAnnotation).
CUL3	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
CUL3	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
CUL3	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
CUL3	transfac_pro__M07387	ZBTB7A (directAnnotation).
CUL3	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
CUL3	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
CUL3	metacluster_144.13	HIC1; HIC1 (directAnnotation).
CUL3	transfac_pro__M00514	ATF4 (directAnnotation).
CUL3	transfac_pro__M00665	SP3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."